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Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmeticsJapan's Standards for Cosmetics


Concern Reference
One or more in vitro tests on mammalian cells show positive mutation resultsCantrell A, McGarvey D, Mulroy L, Truscott T


Concern Reference
One or more human case studies show equivocal skin allergy or allergenic effectsFDA

Data gaps

Concern Reference
44 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Decreased skin absorption

Concern Reference
Limited potential to absorb into the skin.Benech-Kieffer F, Meuling WJ, Leclerc C, Roza L, Leclaire J, Nohynek G

Biochemical or cellular level changes

Concern Reference
Does not produces excess reactive oxygen species or other harmful biochemical changes.Fourtanier A, Moyal D, Seite S

Data Sources

Benech-Kieffer F, Meuling WJ, Leclerc C, Roza L, Leclaire J, Nohynek G. 2003. Percutaneous absorption of Mexoryl SX in human volunteers: comparison with in vitro data. Skin pharmacology and applied skin physiology 16(6): 343-55.
Cantrell A, McGarvey D, Mulroy L, Truscott T. 1999. Laser flash photolysis studies of the UVA sunscreen Mexoryl SX. Photochem Photobiol 70: 292-97.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
FDA. 2006. Center for Drug Evaluation and Research Application Number 21-502: Medical Review. Center for Drug Evaluation and Research, Food and Drug Administration. July 11, 2006.
Fourtanier A, Moyal D, Seite S. 2008. Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. Photodermatol Photoimmunol Photomed 24(4): 164-74.
Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About the Skin Deep® ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer


Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more | Legal Disclaimer