Health Concerns of the Ingredient:
About SUBTILISIN: Subtilisin is an enzyme obtained by fermentation of Bacillus subtilisor Bacillus licheniformis.
Function(s): Lytic Agent; Skin-Conditioning Agent - Miscellaneous; KERATOLYTIC; SKIN CONDITIONING
Synonym(s): BACILLUS SUBTILIS ALKALINE PROTEINASE; BACILLUS SUBTILIS ENZYME FERMENTATION PRODUCT; PROTEINASE, BACILLUS SUBTILIS ALKALINE; SUBTILOPEPTIDASE; ALCALASE; ALK-ENZYME; BACILLOPEPTIDASE A; BACILLOPEPTIDASE B; BIOPRASE; COLISTINASE; E.C. 18.104.22.168
Organ system toxicity (non-reproductive)
|Known human lung and skin toxicant (only for products that may be aerosolized (airborne); products for use on skin)||European Union - Classification & Labelling|
|Limited evidence of immune system toxicity or allergies (only for products that may be aerosolized (airborne))||European Union - Classification & Labelling|
|Limited evidence of immune system toxicity or allergies||National Library of Medicine HazMap|
Irritation (skin, eyes, or lungs)
|Classified as irritant||European Union - Classification & Labelling|
|5,798 studies in PubMed science library may include information on the toxicity of this chemical see search results ->||NLM PubMed|
|Single case study detailing occupational hazards||National Library of Medicine HazMap|
|CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.|
|NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.|
|NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov. |
Products Containing the Ingredient
About the Skin Deep® ratings
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government.
The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more
| Legal Disclaimer
About EWG VERIFIED™
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria.
Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Learn more
| Legal Disclaimer