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SODIUM PCA
Score
Data: Limited
CAS28874-51-3
facial moisturizer/ treatment (177 products)
anti-aging (124 products)
moisturizer (124 products)
facial cleanser (82 products)
conditioner (71 products)
Show all 833 products that contain SODIUM PCA.
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SODIUM PCA


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictionsyes
Contamination concerns: NITROSAMINES

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Hair Conditioning Agent; Humectant; Skin-Conditioning Agent - Humectant; ANTISTATIC; SKIN CONDITIONING

About SODIUM PCA: Sodium PCA is a derivative of naturally occurring amino acid proline; it is used as a conditioning agent.

Synonym(s): 5-OXO-DL-PROLINE, MONOSODIUM SALT; PCA SODA; DL-PROLINE, 5-OXO-, MONOSODIUM SALT; SODIUM PYROGLUTAMATE; SODIUM DL-2-PYRROLIDONE-5-CARBOXYLATE; SODIUM DL-PYRROLIDONECARBOXYLATE SOLUTION; MONOSODIUM SALT 5-OXO-DL-PROLINE; MONOSODIUM SALT DL-PROLINE, 5-OXO-; 5-OXO- MONOSODIUM SALT DL-PROLINE; SODIUM 5-OXO-L-PROLINATE; 5-OXO-L-PROLINE MONOSODIUM SALT

Use restrictions

type of concern product conditions reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications   Cosmetic Ingredient Review Assessments

Data gaps

type of concern product conditions reference
2 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List
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Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
Cosmetic Ingredient Review AssessmentsSODIUM PCAQQQ02,QQQ06; N
Environment Canada Domestic Substance ListDL-PROLINE, 5-OXO-, MONOSODIUM SALT,,,,,,,,,

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- International Journal of Toxicology SODIUM PCA• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Iyakuhin Kenkyu 1992SODIUM PCA• kidney or renal system - Changes in bladder weight (rat TDLo)
• cardiovascular - Changes in heart weight (rat TDLo)
• liver - Changes in liver weight (rat TDLo)
• blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo)
• endocrine system - Changes in testicular weight (rat TDLo)

references
government/industry list/academic study reference
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
RTECS®- International Journal of Toxicology [shown for informational purposes only]RTECS®- International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997- 18(Suppl
RTECS®- Iyakuhin Kenkyu 1992 [shown for informational purposes only]RTECS®- Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- 23,717,1992

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.