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Score
Data: Fair
CAS79-81-2
facial moisturizer/ treatment (377 products)
anti-aging (319 products)
lipstick (304 products)
moisturizer (252 products)
foundation (169 products)
Show all 2,911 products that contain RETINYL PALMITATE (VITAMIN A PALMITATE).
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RETINYL PALMITATE (VITAMIN A PALMITATE)


image source: PubChem
Health concerns of ingredient
About the ratings
Canceryes
Developmental & reproductive toxicityyes
Allergies & immunotoxicity no information
Use restrictionsyes
Contamination concerns: none
Other HIGH concerns: Biochemical or cellular level changes
Other MODERATE concerns: Organ system toxicity (non-reproductive)
Other LOW concerns: Ecotoxicology, Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Skin-Conditioning Agent - Miscellaneous; SKIN CONDITIONING

About RETINYL PALMITATE (VITAMIN A PALMITATE): Retinyl palmitate is an ingredient composed of palmitic acid and retinol (Vitamin A). When exposed to UV light, retinol compounds break down and produce toxic free radicals that can damage DNA and cau ... read more

Synonym(s): RETINYL PALMITATE, AXEROPHTHOL PALMITATE; RETINOL, HEXADECANOATE; RETINOL PALMITATE; VITAMIN A PALMITATE; HEXADECANOATE RETINOL; AQUASOL A; AROVIT; OPTOVIT-A; RETINOL PALMITATE; VITAMIN A PALMITATE

Developmental/reproductive toxicity

type of concern product conditions reference
Known human reproductive toxicant    FDA, 1995
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Use restrictions

type of concern product conditions reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics   Canada - Prohibited and Restricted Cosmetics Ingredients

Biochemical or cellular level changes

type of concern product conditions reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.    Xia Q, Yin JJ, Cherng SH, Wamer WG, Boudreau M, Howard PC, et al, 2006
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.    Cherng SH, Xia Q, Blankenship LR, Freeman JP, Wamer WG, Howard PC, et al, 2005

Cancer

type of concern product conditions reference
One or more animal studies show tumor formation at very low doses    NTP, 2010
One or more animal studies show tumor formation at very low doses skin, lips  "Halliday GM, Robertson BO, Barnetson RSC, 2000
Limited evidence of carcinogenicity    NTP, 2000
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Organ system toxicity (non-reproductive)

type of concern product conditions reference
Limited evidence of skin toxicity    Kang S, Duell EA, Fisher GJ, Datta SC, Wang ZQ, Reddy AP, et al, 1995
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Ecotoxicology

type of concern product conditions reference
Uncertain environmental toxin and uncertain persistent or bioaccumulative    Environment Canada Domestic Substance List

Enhanced skin absorption

type of concern product conditions reference
Absorbs into the skin    Boehnlein J, Sakr A, Lichtin JL, Bronaugh RL, 1994

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food
Designated as safe for general or specific, limited use in food   FDA Food Additive Status

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List
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Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
1,509 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusVITAMIN A PALMITATE• NUTR/DS
• GRAS
• GMP - CFR182.5936; 184.1930
Canada - Prohibited and Restricted Cosmetics IngredientsRETINYL PALMITATERestricted
Cosmetic Ingredient Review AssessmentsRETINYL PALMITATEQQQ01,QQQ11
FDA Everything Added to FoodVITAMIN A PALMITATE• ASP
Environment Canada Domestic Substance ListRETINOL, HEXADECANOATE,,,,,U-AquaticTox,,,,
IFRA Fragrance Ingredient ListRETINOL, HEXADECANOATEreported as used in fragrance compounds in 2008
Mei N, Xia Q, Chen L, Moore MM, Fu PP, Chen T, 2005RETINYL PALMITATEincreased frequency of mutations in cell exposed to retinyl palmitate and UVA (synergistic effect)
Cherng SH, Xia Q, Blankenship LR, Freeman JP, Wamer WG, Howard PC, et al, 2005RETINYL PALMITATEphotoirradiation of retinyl palmitate by UVA light generates reactive oxygen species resulting in lipid peroxidation.
Yan J, Xia Q, Cherng SH, Wamer WG, Howard PC, Yu H, et al, 2005RETINYL PALMITATEphotoirradiation of retinyl palmitate with UVA light generates free radicals that initiate DNA strand cleavage
Xia Q, Yin JJ, Cherng SH, Wamer WG, Boudreau M, Howard PC, et al, 2006RETINYL PALMITATEUVA irradiation of retinyl palmitate induces formation of reactive oxygen species
Boehnlein J, Sakr A, Lichtin JL, Bronaugh RL, 1994RETINYL PALMITATEretinyl palmitate is absorbed into skin and converted to retinol
Duell EA, Kang S, Voorhees JJ, 1997RETINYL PALMITATEtopically applied retinyl palmitate induced epidermal hyperplasia in human skin
Canada - Prohibited and Restricted Cosmetics IngredientsRETINYL ACETATERestricted
Kang S, Duell EA, Fisher GJ, Datta SC, Wang ZQ, Reddy AP, et al, 1995VITAMIN Atopically applied retinol induced epidermal hyperplasia in human skin
NTP, 2000RETINYL PALMITATEretinyl palmitate nominated by FDA for photocarcinogenicity testing by the National Toxicology Panel
"Halliday GM, Robertson BO, Barnetson RSC, 2000RETINOIC ACIDScientists found an increase in skin tumors in animals treated wtih retinoic acid in a study using a protocol to mimic human use of the ingredient.
Hathcock JN, Hattan DG, Jenkens MY, McDonald JT, Sundaresan PR, Wilkening VL, 1990RETINOLRetinol is associated with birth defects at maternal intakes as low as 25,000 IU/day
FDA, 1995RETINOLFDA has more recently recommended that women of child-bearing age limit their intake of retinol to 5000 IU (1.5 mg retinol)/day
NTP, 2010RETINYL PALMITATEOne-year study found higher rates and greater numbers of skin tumors and lesions on RP-treated animals exposed to 4 hours of sunlight daily

Other RTECS® classifications [shown for informational purposes only]

government/industry list/academic study appears on list as classification(s)
RTECS®- "Environmental Variables in Oral Disease; A Symposium Presented at the Montreal Meeting of the American Association for the Advancement of Science, 1964," Kreshover, S 1966RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Post-implantation mortality (mouse TDLo)
RTECS®- Acta Anatomica 1981RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Musculoskeletal system (rat TDLo)
RTECS®- AMA Archives of Pathology 1953RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Testes, epididymis, sperm duct (rat TDLo)
RTECS®- Anatomical Record 1960RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Cardiovascular (mouse TDLo)
• developmental - Urogenital system (mouse TDLo)
RTECS®- Anatomischer Anzeiger 1982RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Cytological changes (rat TDLo)
RTECS®- British Journal of Experimental Pathology 1976RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Post-implantation mortality (rat TDLo)
RTECS®- Japanese Journal of Genetics 1966RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Fetal death (rabbit TDLo)
• reproductive - Musculoskeletal system (mouse TDLo)
RTECS®- Journal of Embryology and Experimental Morphology 1973RETINYL PALMITATE (VITAMIN A PALMITATE)• developmental - Central nervous system (rat TDLo)
• reproductive - Eye, ear (rat TDLo)
• reproductive - Musculoskeletal system (rat TDLo)
• reproductive - Post-implantation mortality (rat TDLo)
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1964RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Central nervous system (rat TDLo)
• reproductive - Post-implantation mortality (rat TDLo)
RTECS®- Journal of Reproduction and Fertility 1977RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Other measures of fertility (rat TDLo)
• reproductive - Ovaries, fallopian tubes (rat TDLo)
• reproductive - Uterus, cervix, vagina (rat TDLo)
RTECS®- Journal of the American Academy of Dermatology 1982RETINYL PALMITATE (VITAMIN A PALMITATE)• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Journal of the Anatomical Society of India 1974RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Central nervous system (rat TDLo)
• developmental - Craniofacial (rat TDLo)
RTECS®- Mutagenesis 2004RETINYL PALMITATE (VITAMIN A PALMITATE)• mutagenic - Positive mutation assay: DNA Damage (rat orl)
RTECS®- Mutation Research 1978RETINYL PALMITATE (VITAMIN A PALMITATE)• mutagenic - Positive mutation assay: Sister Chromatid Exchange ( human fbr)
RTECS®- Mutation Research 1978RETINYL PALMITATE (VITAMIN A PALMITATE)• mutagenic - Positive mutation assay: Sister Chromatid Exchange ( human fbr)
RTECS®- Neurotoxicology and Teratology 2005RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Fetotoxicity (rat TDLo)
RTECS®- Pharmacology, Biochemistry and Behavior 1991RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Behavioral (rat TDLo)
RTECS®- Reproductive Toxicology 2000RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Cardiovascular (monkey TDLo)
• reproductive - Eye, ear (monkey TDLo)
• developmental - Musculoskeletal system (monkey TDLo)
RTECS®- Senten Ijo 1974RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Fetal death (mouse TDLo)
• developmental - Musculoskeletal system (mouse TDLo)
RTECS®- Teratology, The International Journal of Abnormal Development 1974RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Behavioral (rat TDLo)
RTECS®- Teratology, The International Journal of Abnormal Development 1980RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Behavioral (rat TDLo)
RTECS®- Teratology, The International Journal of Abnormal Development 1981RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Craniofacial (mouse TDLo)
RTECS®- Teratology, The International Journal of Abnormal Development 1983RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Eye, ear (mammal TDLo)
• reproductive - Musculoskeletal system (mammal TDLo)
RTECS®- Teratology, The International Journal of Abnormal Development 1987RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Craniofacial (mouse TDLo)
RTECS®- Teratology, The International Journal of Abnormal Development 1974RETINYL PALMITATE (VITAMIN A PALMITATE)• reproductive - Fetotoxicity (mouse TDLo)
RTECS®- Voprosy Onkologii 1979RETINYL PALMITATE (VITAMIN A PALMITATE)• metabolic - Weight loss or decreased weight gain (mouse LD50)
• gastrointestinal - Hypermotility, diarrhea (mouse LD50)
• brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (mouse LD50)

references

government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Canada - Prohibited and Restricted Cosmetics IngredientsHealth Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Open scientific literatureMei N, Xia Q, Chen L, Moore MM, Fu PP, Chen T. 2005. Photomutagenicity of retinyl palmitate by ultraviolet a irradiation in mouse lymphoma cells. Toxicol Sci 88(1): 142-9.
Open scientific literatureCherng SH, Xia Q, Blankenship LR, Freeman JP, Wamer WG, Howard PC, et al. 2005. Photodecomposition of retinyl palmitate in ethanol by UVA light-formation of photodecomposition products, reactive oxygen species, and lipid peroxides. Chem Res Toxicol 18(2): 129-38
Open scientific literatureYan J, Xia Q, Cherng SH, Wamer WG, Howard PC, Yu H, et al. 2005. Photo-induced DNA damage and photocytotoxicity of retinyl palmitate and its photodecomposition products. Toxicol Ind Health 21(7-8): 167-75
Open scientific literatureXia Q, Yin JJ, Cherng SH, Wamer WG, Boudreau M, Howard PC, et al. 2006. UVA photoirradiation of retinyl palmitate--formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation. Toxicol Lett 163(1): 30-43
Open scientific literatureBoehnlein J, Sakr A, Lichtin JL, Bronaugh RL. 1994. Characterization of esterase and alcohol dehydrogenase activity in skin. Metabolism of retinyl palmitate to retinol (vitamin A) during percutaneous absorption. Pharm Res 11(8): 1155-9.
Open scientific literatureDuell EA, Kang S, Voorhees JJ. 1997. Unoccluded retinol penetrates human skin in vivo more effectively than unoccluded retinyl palmitate or retinoic acid. J Invest Dermatol 109(3): 301-5.
Open scientific literatureKang S, Duell EA, Fisher GJ, Datta SC, Wang ZQ, Reddy AP, et al. 1995. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol 105(4): 549-56.
Open scientific literatureNTP. 2000. All-Trans-Retinyl Palmitate [CASRN 79-81-2]. http://ntp.niehs.nih.gov/ntp/htdocs/Chem_Background/ExSumPdf/RetinylPalmitate.pdf
Open scientific literature"Halliday GM, Robertson BO, Barnetson RSC. 2000. Topical Retinoic Acid Enhances, and a Dark Tan Protects, from Subedemal Solar-Simulated Photocarcinogenesis. J. Invest. Dermatol. 114: 923-927."
Open scientific literatureHathcock JN, Hattan DG, Jenkens MY, McDonald JT, Sundaresan PR, Wilkening VL. 1990. Evaluation of vitamin A toxicity. Am J Clin Nutr 52, 183–202.
Open scientific literatureFDA, 1995. FDA Talk Paper: Vitamin A and Birth Defects. US Food and Drug Administration
Open scientific literatureNTP. 2010. NTP Draft Technical Report on the Photococarcinogenesis Study of Retinoic Acid and Retinyl Palmitate [CAS Nos. 302-79-4 (All-Trans-Retinoic Acid) and 79-81-2 (All-Trans-Retinyl Palmitate)] in SKH-1 Mice (Simulated Solar Light And Topical Application Study). NIH Publication No. 11-5910
RTECS®- "Environmental Variables in Oral Disease; A Symposium Presented at the Montreal Meeting of the American Association for the Advancement of Science, 1964," Kreshover, S 1966 [shown for informational purposes only]RTECS®- "Environmental Variables in Oral Disease; A Symposium Presented at the Montreal Meeting of the American Association for the Advancement of Science, 1964," Kreshover, S.J., et al., eds., Washington, DC, American Assoc. for the Advancement of Science, 1966 -,273,1966
RTECS®- Acta Anatomica 1981 [shown for informational purposes only]RTECS®- Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1945- 109,89,1981
RTECS®- AMA Archives of Pathology 1953 [shown for informational purposes only]RTECS®- AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. 56,333,1953
RTECS®- Anatomical Record 1960 [shown for informational purposes only]RTECS®- Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- 136,219,1960
RTECS®- Anatomischer Anzeiger 1982 [shown for informational purposes only]RTECS®- Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.) V.1- 1886- 152,329,1982
RTECS®- British Journal of Experimental Pathology 1976 [shown for informational purposes only]RTECS®- British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- 57,525,1976
RTECS®- Japanese Journal of Genetics 1966 [shown for informational purposes only]RTECS®- Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921- 41,141,1966
RTECS®- Journal of Embryology and Experimental Morphology 1973 [shown for informational purposes only]RTECS®- Journal of Embryology and Experimental Morphology. (Essex, UK) V.1-98, 1953-86. For Publisher information, see DEVPED 30,219,1973
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1964 [shown for informational purposes only]RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 144,429,1964
RTECS®- Journal of Reproduction and Fertility 1977 [shown for informational purposes only]RTECS®- Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- 50,223,1977
RTECS®- Journal of the American Academy of Dermatology 1982 [shown for informational purposes only]RTECS®- Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- 6,652,1982
RTECS®- Journal of the Anatomical Society of India 1974 [shown for informational purposes only]RTECS®- Journal of the Anatomical Society of India. (Dept. of Anatomy, Medical College, Aurangabad 431 001, India) V.1- 1952- 23,89,1974
RTECS®- Mutagenesis 2004 [shown for informational purposes only]RTECS®- Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 19,231,2004
RTECS®- Mutation Research 1978 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 58,317,1978
RTECS®- Mutation Research 1978 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 58,317,1978
RTECS®- Neurotoxicology and Teratology 2005 [shown for informational purposes only]RTECS®- Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- 27,855,2005
RTECS®- Pharmacology, Biochemistry and Behavior 1991 [shown for informational purposes only]RTECS®- Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- 38,739,1991
RTECS®- Reproductive Toxicology 2000 [shown for informational purposes only]RTECS®- Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- 14,311,2000
RTECS®- Senten Ijo 1974 [shown for informational purposes only]RTECS®- Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. 14,13,1974
RTECS®- Teratology, The International Journal of Abnormal Development 1974 [shown for informational purposes only]RTECS®- Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- 10,269,1974
RTECS®- Teratology, The International Journal of Abnormal Development 1980 [shown for informational purposes only]RTECS®- Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- 21,25A,1980
RTECS®- Teratology, The International Journal of Abnormal Development 1981 [shown for informational purposes only]RTECS®- Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- 23,115,1981
RTECS®- Teratology, The International Journal of Abnormal Development 1983 [shown for informational purposes only]RTECS®- Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- 28,37A,1983
RTECS®- Teratology, The International Journal of Abnormal Development 1987 [shown for informational purposes only]RTECS®- Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- 35,105,1987
RTECS®- Teratology, The International Journal of Abnormal Development 1974 [shown for informational purposes only]RTECS®- Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- 9,191,1974
RTECS®- Voprosy Onkologii 1979 [shown for informational purposes only]RTECS®- Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- 25(12),84,1979

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