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QUATERNIUM-15 (FORMALDEHYDE RELEASER)


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
 

About QUATERNIUM-15 (FORMALDEHYDE RELEASER): This ingredient is a quaternary ammonium salt used as a preservative; it acts as a formaldehyde releaser. The European Union has determined that this ingredient 'may not be safe' in cosmetics.

Function(s): Antistatic Agent; Preservative

Synoym(s): QUATERNIUM-15, 1- (3-CHLORO-2-PROPENYL) - 3,5,7-TRIAZA-1-AZONIATRICYCLO [3.3.1.1] DECANE; 1- (3-CHLORO-2-PROPENYL) -3,5,7-TRIAZA-1-AZONIATRICYCLO [3.3.1.1] DECANE CHLORIDE; 1- (3-CHLOROALLYL) -3,5,7-TRIAZA-1-AZONIAADAMANTANE CHLORIDE; 3,5,7-TRIAZA-1-AZONIATRICYCLO [3.3.1.1] DECANE, 1- (3-CHLORO-2-PROPENYL) -; 3,5,7TRIAZA1AZONIATRICYCLO [3.3.1.13,7] DECANE, 1 (3CHLORO2PROPENYL) , CHLORIDE; CHLOROALLYL METHENAMINE CHLORIDE; METHENAMINE 3-CHLOROALLY LCHLORIDE; METHENAMINE 3-CHLOROALLYLOCHLORIDE; N- (3-CHLOROALLYL) HEXAMINIUM CHLORIDE; 1- (3-CHLOROALLYL) -3,5,7-TRIAZA-1-AZONIAADAMANTANE CHLORIDE; DOWCO 184

Allergies/immunotoxicity

Concern Reference
Known human skin sensitizer toxicant or allergenScientific Committee on Consumer Safety (SCCS) OPINION ON Quaternium-15 (cis-isomer), COLIPA n° P63
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Use restrictions

Concern Reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Scientific Committee on Consumer Safety (SCCS) OPINION ON Quaternium-15 (cis-isomer), COLIPA n° P63
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as medium human health priorityEnvironment Canada Domestic Substance List
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs

Cancer

Concern Reference
Cancer - limited evidenceIARC (International Agency for Research on Cancer)

Irritation (skin, eyes, or lungs)

Concern Reference
Possible human eye, skin irritantScientific Committee on Consumer Safety (SCCS) OPINION ON Quaternium-15 (cis-isomer), COLIPA n° P63

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
85 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Chemical release concerns

Chemical Score
FORMALDEHYDE
Data: Fair

Persistence and bioaccumulation

Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Scientific Committee on Consumer Safety (SCCS) OPINION ON Quaternium-15 (cis-isomer), COLIPA n° P63. December 2011.
Scientific Committee on Consumer Safety (SCCS) OPINION ON Quaternium-15 (cis-isomer), COLIPA n° P63. December 2011.
Scientific Committee on Consumer Safety (SCCS) OPINION ON Quaternium-15 (cis-isomer), COLIPA n° P63. December 2011.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer