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QUATERNIUM-15
Score
Data: Fair
CAS4080-31-3
facial powder (80 products)
eye shadow (77 products)
foundation (36 products)
mascara (31 products)
blush (30 products)
Show all 405 products that contain QUATERNIUM-15.
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QUATERNIUM-15


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicityyes
Use restrictionsyes
Contamination concerns: FORMALDEHYDE
Other MODERATE concerns: Organ system toxicity (non-reproductive)
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Antistatic Agent; Preservative

About QUATERNIUM-15: This ingredient is a quaternary ammonium salt used as a preservative; it acts as a formaldehyde releaser.

Synonym(s): N- (3-CHLOROALLYL) HEXAMINIUM CHLORIDE; CHLOROALLYL METHENAMINE CHLORIDE; 1- (3-CHLOROALLYL) -3,5,7-TRIAZA-1-AZONIAADAMANTANE CHLORIDE; METHENAMINE 3-CHLOROALLY LCHLORIDE; METHENAMINE 3-CHLOROALLYLOCHLORIDE; 1- (3-CHLOROALLYL) -3,5,7-TRIAZA-1-AZONIAADAMANTANE CHLORIDE; DOWCO 184; DOWICIDE Q; DOWICIL 100; DOWICIL 75; QUATERNIUM 15

Allergies/immunotoxicity

type of concern product conditions reference
Known human immune system toxicant    National Library of Medicine HazMap
Human skin toxicant - strong evidence    Cosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as expected to be toxic or harmful    Environment Canada Domestic Substance List
Classified as medium human health priority    Environment Canada Domestic Substance List
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Use restrictions

type of concern product conditions reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications   Cosmetic Ingredient Review Assessments

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
69 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
Cosmetic Ingredient Review AssessmentsQUATERNIUM-15QQQ02,QQQ11; S, R+, D+, M-
Environment Canada Domestic Substance List3,5,7-TRIAZA-1-AZONIATRICYCLO[ 3.3.1.13#,7]DECANE, 1-(3-CHLORO-2-PROPENYL)-, CHLORIDEY-Categorization,Y-Human health,Moderate-Health Priority,Y-Persistent,,,,,,
National Library of Medicine HazMapQUATERNIUM-15SS: Yes;
EPA Toxic Release Inventory PBTsCHLORIDE3,5,7TRIAZA1AZONIATRICYCLO[3.3.1.13,7]DECANE, 1(3CHLORO2PROPENYL)Toxic under the EPA's Toxics Release Inventory
US EPA, 17881-(3-CHLOROALLYL)-3,5,7-TRIAZA-1-AZONIAADAMANTANE CHLORIDECardiovascular or Blood Toxicity Hazards: suspected

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Environmental and Molecular Mutagenesis 1988QUATERNIUM-15• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- Environmental and Molecular Mutagenesis 1988QUATERNIUM-15• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- Journal of the American College of Toxicology 1986QUATERNIUM-15• skin - Primary skin irritant (rabbit )
RTECS®- Journal of the American College of Toxicology 1986QUATERNIUM-15• reproductive - Eye, ear (rat TDLo)
• broad systemic - Broad systemic toxicity (rabbit LD50)
• brain, nervous system, or behavioral effect - Changes in brain weight (rabbit TDLo)
• endocrine system - Changes in testicular weight (rabbit TDLo)
• liver - Other changes (rabbit TDLo)
• skin - Primary skin irritant (rabbit )
RTECS®- Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc 1966QUATERNIUM-15• broad systemic - Broad systemic toxicity (rat LD50)

references
government/industry list/academic study reference
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
EPA Toxic Release Inventory PBTsEPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
Scorecard.org Toxicity InformationUS EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm
RTECS®- Environmental and Molecular Mutagenesis 1988 [shown for informational purposes only]RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- 11(Suppl 12),1,1988
RTECS®- Environmental and Molecular Mutagenesis 1988 [shown for informational purposes only]RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 11(Suppl 12),1,1988
RTECS®- Journal of the American College of Toxicology 1986 [shown for informational purposes only]RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 5(3),61,1986
RTECS®- Journal of the American College of Toxicology 1986 [shown for informational purposes only]RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 5(3),61,1986
RTECS®- Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc 1966 [shown for informational purposes only]RTECS®- Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) -,455,1966

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