| Score |  Data: Fair |
| CAS | 57-55-6 |
| hair color and bleaching (630 products) | |
| facial moisturizer/ treatment (424 products) | |
| conditioner (383 products) | |
| moisturizer (355 products) | |
| anti-aging (348 products) | |
| Show all 5,562 products that contain PROPYLENE GLYCOL. | |
| how to read the score | |
 image source: PubChem |
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Function/use(s): Fragrance Ingredient; Humectant; Skin-Conditioning Agent - Humectant; Skin-ConditioningAgent - Miscellaneous; Solvent; Viscosity Decreasing Agent; SKIN CONDITIONING; VISCOSITY CONTROLLING
About PROPYLENE GLYCOL: Propylene glycol is a small organic alcohol commonly used as a skin conditioning agent. It has been associated with irritant and allergic contact dermatitis as well as contact urticaria in humans; the ... read more
Synonym(s): 1,2-DIHYDROXYPROPANE; 2-HYDROXYPROPANOL; METHYLETHYL GLYCOL; 1,2-PROPANEDIOL; PROPANE-1,2-DIOL; 1,2-DIHYDROXYPROPANE; 1,2-PROPYLENE GLYCOL; 1,2-PROPYLENGLYKOL (GERMAN) ; ALPHA-PROPYLENEGLYCOL; DOWFROST; METHYLETHYLENE GLYCOL
Allergies/immunotoxicity | ||
|---|---|---|
| type of concern | product conditions | reference |
| Limited evidence of skin and immune system toxicity | CIR (Cosmetic Ingredient Review), 2006 | |
Organ system toxicity (non-reproductive) | ||
|---|---|---|
| type of concern | product conditions | reference |
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List | |
| Limited evidence of respiratory toxicity | products that may be aerosolized (airborne) | Agency for Toxic Substances and Disease Registry, 2004 |
Irritation (skin, eyes, or lungs) | ||
|---|---|---|
| type of concern | product conditions | reference |
| Classified as skin irritant | National Library of Medicine HazMap | |
Use restrictions | ||
|---|---|---|
| type of concern | product conditions | reference |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments | |
Enhanced skin absorption | ||
|---|---|---|
| type of concern | product conditions | reference |
| Penetration enhancer | Cosmetic Ingredient Review Assessments | |
Multiple, additive exposure sources | ||
|---|---|---|
| type of concern | product conditions | reference |
| Designated as safe for general or specific, limited use in food | FDA Food Additive Status | |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food | |
Developmental/reproductive toxicity | ||
|---|---|---|
| type of concern | product conditions | reference |
| Not likely to be a toxicant in humans | NTP - Risks to Human Reproduction | |
Data gaps | ||
|---|---|---|
| type of concern | product conditions | reference |
| Safety assessment was based on related chemical | Cosmetic Ingredient Review Assessments | |
| 4,177 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed | |
Government, industry, academic studies and classifications |
||
|---|---|---|
| government/industry list/academic study | appears on list as | classification(s) |
| FDA Food Additive Status | PROPYLENE GLYCOL | • MISC • GRAS/FS - CFR184.1666 • Part 169 (169.175; 169.176; 169.177; 169.178; 169.180; 169.181) • Vanilla Extract • Carrier for enzyme modified soy protein • Part 582.1666 - In animal feeds |
| Cosmetic Ingredient Review Assessments | PROPYLENE GLYCOL | QQQ02,QQQ36; PE, QQQ50 |
| FDA Everything Added to Food | PROPYLENE GLYCOL | • ASP |
| Environment Canada Domestic Substance List | 1,2-PROPANEDIOL | Y-Categorization,Y-Human health,Moderate-Health Priority,,,,,,, |
| IFRA Fragrance Ingredient List | PROPYLENE GLYCOL | reported as used in fragrance compounds in 2008 |
| National Library of Medicine HazMap | PROPYLENE GLYCOL | SS: Yes;LA: Yes; |
| NTP - Risks to Human Reproduction | PROPYLENE GLYCOL | REPRO: Negligible concern || DEVELOPMENT: Negligible concern |
| CIR (Cosmetic Ingredient Review), 2006 | PROPYLENE GLYCOL | Propylene glycol was found to provoke allergic reactions in patients with eczema and other skin allergies. |
| Agency for Toxic Substances and Disease Registry, 2004 | PROPYLENE GLYCOL | Respiratory Toxicity Hazards: suspected |
Other RTECS® classifications [shown for informational purposes only] |
||
|---|---|---|
| government/industry list/academic study | appears on list as | classification(s) |
| RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 | PROPYLENE GLYCOL | • skin - Primary skin irritant ( human ) |
| RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 | PROPYLENE GLYCOL | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 | PROPYLENE GLYCOL | • brain, nervous system, or behavioral effect - Ataxia (rat LD50) • respiratory - Respiratory depression (rat LD50) • brain, nervous system, or behavioral effect - Tetany (rat LD50) |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 | PROPYLENE GLYCOL | • brain, nervous system, or behavioral effect - Ataxia (rabbit LDLo) • respiratory - Respiratory depression (rabbit LDLo) • brain, nervous system, or behavioral effect - Tetany (rabbit LDLo) |
| RTECS®- Acta Pathologica et Microbiologica Scandinavica, Section A, Supplement 1981 | PROPYLENE GLYCOL | • mutagenic - Positive mutation assay: Cytogenetic Analysis (mouse scu) • mutagenic - Positive mutation assay: DNA Inhibition (mouse scu) |
| RTECS®- Arzneimittel-Forschung 1976 | PROPYLENE GLYCOL | • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- FAO Nutrition Meetings Report Series 1974 | PROPYLENE GLYCOL | • broad systemic - Broad systemic toxicity (rabbit LD50) |
| RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology 1947 | PROPYLENE GLYCOL | • kidney or renal system - Changes in both tubules and glomeruli (mouse LD50) • blood - Changes in spleen (mouse LD50) • respiratory - Chronic pulmonary edema (mouse LD50) |
| RTECS®- Food and Chemical Toxicology 1982 | PROPYLENE GLYCOL | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Food and Chemical Toxicology 1984 | PROPYLENE GLYCOL | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr) |
| RTECS®- Food and Chemical Toxicology 1982 | PROPYLENE GLYCOL | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Food and Chemical Toxicology 1984 | PROPYLENE GLYCOL | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr) |
| RTECS®- Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 17JUN1974 | PROPYLENE GLYCOL | • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- Journal of Industrial Hygiene and Toxicology 1941 | PROPYLENE GLYCOL | • broad systemic - Broad systemic toxicity (guinea pig LD50) |
| RTECS®- Journal of Investigative Dermatology 1970 | PROPYLENE GLYCOL | • skin - Primary skin irritant ( human ) |
| RTECS®- Journal of Investigative Dermatology 1970 | PROPYLENE GLYCOL | • skin - Primary skin irritant ( human ) |
| RTECS®- Journal of Pediatrics 1978 | PROPYLENE GLYCOL | • brain, nervous system, or behavioral effect - General anesthetic (child TDLo) • brain, nervous system, or behavioral effect - Changes in surface EEG (child TDLo) • brain, nervous system, or behavioral effect - Convulsions or effect on seizure threshold (child TDLo) |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1932 | PROPYLENE GLYCOL | • brain, nervous system, or behavioral effect - Coma (rabbit LDLo) • respiratory - Respiratory stimulation (rabbit LDLo) • brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (rabbit LDLo) |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1937 | PROPYLENE GLYCOL | • cardiovascular - Other changes (chicken LDLo) |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1939 | PROPYLENE GLYCOL | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Journal of the American Academy of Dermatology 2000 | PROPYLENE GLYCOL | • skin - Primary skin irritant (child ) |
| RTECS®- Kaibogaku Zasshi 1962 | PROPYLENE GLYCOL | • reproductive - Fetotoxicity (mouse TDLo) • reproductive - Post-implantation mortality (mouse TDLo) |
| RTECS®- Kriobiologiya i Kriomeditsina 1981 | PROPYLENE GLYCOL | • brain, nervous system, or behavioral effect - Changes in motor activity (specific assay) (mouse LD50) • respiratory - Cyanosis (mouse LD50) • brain, nervous system, or behavioral effect - Muscle contraction or spasticity (mouse LD50) |
| RTECS®- Kriobiologiya i Kriomeditsina 1981 | PROPYLENE GLYCOL | • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- National Technical Information Service | PROPYLENE GLYCOL | • broad systemic - Broad systemic toxicity (rabbit LD50) |
| RTECS®- Pediatrics 1983 | PROPYLENE GLYCOL | • metabolic - Other changes (infant TDLo) |
| RTECS®- Raw Material Data Handbook, Vol 1974 | PROPYLENE GLYCOL | • broad systemic - Broad systemic toxicity (rabbit LD50) |
| RTECS®- Toxic Substance Mechanisms 1995 | PROPYLENE GLYCOL | • endocrine system - Hyperglycemia (rat TDLo) • biochemical - Phosphatases (rat TDLo) • biochemical - Transaminases (rat TDLo) |
| RTECS®- Toxicology and Applied Pharmacology 1978 | PROPYLENE GLYCOL | • broad systemic - Broad systemic toxicity (rat LD50) |
references |
||
|---|---|---|
| government/industry list/academic study | reference | |
| FDA Food Additive Status | FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006. | |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. | |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. | |
| Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. | |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 | |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. | |
| NTP - Risks to Human Reproduction | NTP (National Toxicology Program). 2006. NTP Center for the Evaluation fo Risks to Human Reproduction (CERHR). NTP-CERHR Reports and Monographs. | |
| Open scientific literature | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. | |
| Scorecard.org Toxicity Information | Agency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, 2004 | |
| RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 [shown for informational purposes only] | RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 -,127,1977 | |
| RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 [shown for informational purposes only] | RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,206,1986 | |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 [shown for informational purposes only] | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,149,1984 | |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 [shown for informational purposes only] | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,150,1984 | |
| RTECS®- Acta Pathologica et Microbiologica Scandinavica, Section A, Supplement 1981 [shown for informational purposes only] | RTECS®- Acta Pathologica et Microbiologica Scandinavica, Section A, Supplement. (Copenhagen, Denmark) No.210-274, 1970-81. For publisher information, see ACPADQ. 274,304,1981 | |
| RTECS®- Arzneimittel-Forschung 1976 [shown for informational purposes only] | RTECS®- Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- 26,1581,1976 | |
| RTECS®- FAO Nutrition Meetings Report Series 1974 [shown for informational purposes only] | RTECS®- FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. 53A,491,1974 | |
| RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology 1947 [shown for informational purposes only] | RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. 6,342,1947 | |
| RTECS®- Food and Chemical Toxicology 1982 [shown for informational purposes only] | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 20,573,1982 | |
| RTECS®- Food and Chemical Toxicology 1984 [shown for informational purposes only] | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 22,623,1984 | |
| RTECS®- Food and Chemical Toxicology 1982 [shown for informational purposes only] | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 20,573,1982 | |
| RTECS®- Food and Chemical Toxicology 1984 [shown for informational purposes only] | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 22,623,1984 | |
| RTECS®- Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 17JUN1974 [shown for informational purposes only] | RTECS®- Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 17JUN1974 | |
| RTECS®- Journal of Industrial Hygiene and Toxicology 1941 [shown for informational purposes only] | RTECS®- Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. 23,259,1941 | |
| RTECS®- Journal of Investigative Dermatology 1970 [shown for informational purposes only] | RTECS®- Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- 55,190,1970 | |
| RTECS®- Journal of Investigative Dermatology 1970 [shown for informational purposes only] | RTECS®- Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 55,190,1970 | |
| RTECS®- Journal of Pediatrics 1978 [shown for informational purposes only] | RTECS®- Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- 93,515,1978 | |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1932 [shown for informational purposes only] | RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 44,109,1932 | |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1937 [shown for informational purposes only] | RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 60,312,1937 | |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1939 [shown for informational purposes only] | RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 65,89,1939 | |
| RTECS®- Journal of the American Academy of Dermatology 2000 [shown for informational purposes only] | RTECS®- Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- 42,355,2000 | |
| RTECS®- Kaibogaku Zasshi 1962 [shown for informational purposes only] | RTECS®- Kaibogaku Zasshi. Journal of Anatomy. (Nippon Kaibo Gakkai, c/o Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1928- 37,239,1962 | |
| RTECS®- Kriobiologiya i Kriomeditsina 1981 [shown for informational purposes only] | RTECS®- Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1975- 8,46,1981 | |
| RTECS®- Kriobiologiya i Kriomeditsina 1981 [shown for informational purposes only] | RTECS®- Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1975- 9,36,1981 | |
| RTECS®- National Technical Information Service [shown for informational purposes only] | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB280-477 | |
| RTECS®- Pediatrics 1983 [shown for informational purposes only] | RTECS®- Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- 72,353,1983 | |
| RTECS®- Raw Material Data Handbook, Vol 1974 [shown for informational purposes only] | RTECS®- Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) 1,101,1974 | |
| RTECS®- Toxic Substance Mechanisms 1995 [shown for informational purposes only] | RTECS®- Toxic Substance Mechanisms. (Taylor & Francis, 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.14- 1995- 14,13,1995 | |
| RTECS®- Toxicology and Applied Pharmacology 1978 [shown for informational purposes only] | RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 45,362,1978 | |
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