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Data: Fair

Proline

IMAGE SOURCE: PubChem

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Other Concerns


SYNONYMS

● DL-PROLINE
● L-PROLINE
● PROLINE

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation


This ingredient can contain either D, L, or DL-proline, an amino acid. L-proline is the isomer of proline found in proteins.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • LOW
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

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facial moisturizer/treatment48 products
foundation44 products
conditioner42 products
shampoo42 products
serums & essences33 products
mask26 products
hair treatment/serum25 products
facial cleanser19 products
moisturizer17 products
around-eye cream17 products
hair styling aide16 products
body wash/cleanser12 products
exfoliant/scrub10 products
anti-aging8 products
liquid hand soap5 products
toners/astringents5 products
hair color and bleaching4 products
brow liner3 products
styling gel/lotion3 products
daily use with SPF3 products
makeup remover3 products
hair spray3 products
lip balm3 products
damaged skin treatment2 products
detangler2 products
bar soap2 products
hair-loss treatment2 products
recreational sunscreen2 products
antiperspirant/deodorant1 products
beard cleanser1 products
after sun product1 products
styling mousse/foam1 products
shaving cream1 products
fragrance for women1 products
eye makeup remover1 products
other eye makeup1 products
body firming lotion1 products
hand cream1 products

Ecotoxicology

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CONCERN REFERENCE
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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CONCERN REFERENCE
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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CONCERN REFERENCE
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyOpen scientific literature

Data gaps

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CONCERN REFERENCE
40209 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • Open scientific/peer reviewed literature
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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