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Score:
Data available:
 
Fair

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PROGESTERONE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
 
Allergies & immunotoxicity
 
 

About PROGESTERONE: Progesterone is a steroid.

This ingredient may be derived from animals. From PETA's Caring Consumer: A steroid hormone used in anti-wrinkle face creams. Can have adverse systemic effects. Alternatives: synthetics.

Possible impurity in: PLACENTAL PROTEIN (1 products), PLACENTA ENZYMES (1 products), PLACENTAL EXTRACT (1 products), PLACENTAL LIPIDS, BOVINE , PLACENTAL EXTRACT, HUMAN, LYOPHILIZED , PLACENTAL EXTRACT, HUMAN, LIQUID , HUMAN PLACENTAL PROTEIN HYDROLYSATE , BOVINE PLACENTAL PROTEIN , BOVINE PLACENTAL EXTRACT , ANIMAL PLACENTAL EXTRACT , see all ingredients | products

Function(s): Skin-Conditioning Agent - Miscellaneous; SKIN CONDITIONING

Synonym(s): PREGN-4-ENE-3,20-DIONE; PREGN-4-ENE3,20-DIONE

Use restrictions

Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCosIng

Developmental/reproductive toxicity

Concern Reference
Possible human developmental toxicant

Cancer

Concern Reference
Possible human carcinogenNTP Report on Carcinogens, 11th Edition
Possible human carcinogenCalifornia EPA Proposition 65
Cancer - limited evidenceSilent Spring's Mammary Carcinogens Reviews Database

Endocrine disruption

Concern Reference
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox study

Data gaps

Concern Reference
88,489 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Multiple, additive exposure sources

Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status

Data Sources

California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Rudel RA, KR Attfield, JN Schifano and JG Brody. Chemicals Causing Mammary Gland Tumors in Animals Signal New Directions for Epidemiology, Chemicals Testing, and Risk Assessment for Breast Cancer Prevention. CANCER Supplement. 2007 Jun 15;109(12):2635-2666.

About the Skin Deep® ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

About EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Learn more | Legal Disclaimer