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POLYSORBATE-60
Score
Data: Limited
CAS9005-67-8
moisturizer (184 products)
facial moisturizer/ treatment (138 products)
anti-aging (109 products)
conditioner (78 products)
foundation (65 products)
Show all 927 products that contain POLYSORBATE-60.
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POLYSORBATE-60


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictionsyes
Contamination concerns: ETHYLENE OXIDE, 1,4-DIOXANE
Other MODERATE concerns: Organ system toxicity (non-reproductive)
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Fragrance Ingredient; Surfactant - Emulsifying Agent; Surfactant - Solubilizing Agent

About POLYSORBATE-60: Polysorbate 60 (Tween-60) is a sorbitol-based emulsifier and surfactant.

Synonym(s): POLYSORBATE 60, POLYOXYETHYLENE (20) SORBITAN MONOSTEARATE; SORBIMACROGOL STEARATE 300; SORBITAN, MONOOCTADECANOATE, POLY (OXY-1,2-ETHANEDIYL) DERIVS.; POLY (OXY-1,2-ETHANEDIYL) DERIVS. SORBITAN, MONOOCTADECANOATE; MONOOCTADECANOATE POLY (OXY-1,2-ETHANEDIYL) DERIVS. SORBITAN; MONOOCTADECANOATE SORBITAN, POLY (OXY-1,2-ETHANEDIYL) DERIVS; SORBITAN, MONOOCTADECANOATE, POLY (OXY1,2ETHANEDIYL) DERIVS.; GLYCOSPERSE S-20; POLYOXYETHYLENE 20 SORBITAN MONOSTEARATE; POLYOXYETHYLENE SORBITAN MONOSTEARATE; POLYOXYETHYLENE-40-SORBITAN MONOSTEARATE

Use restrictions

type of concern product conditions reference
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin products for use on damaged skin Cosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Limited evidence of sense organ toxicity    Harvell, J, 1994
show more

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
206 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food
Designated as safe for general or specific, limited use in food   FDA Food Additive Status

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusPOLYOXYETHYLENE (20) SORBITAN MONOSTEARATE• See Polysorbate 60 - CFR172.836
FDA Food Additive StatusPOLYSORBATE 60• EMUL
• REG
• < 0.40% alone or w/one or comb of sorbitan monostearate
• Polysorbate 80
• Polysorbate 65 In whipped veg oil topping. Total amount any comb < 0.77% - CFR172.836
• REG
• < 0.46% alone or any w/sorbitan mono-stearate Polysorbate 65 - In cake mixes & cake
Cosmetic Ingredient Review AssessmentsPOLYSORBATE-60QQQ01,QQQ11; M-, C+
FDA Everything Added to FoodPOLYSORBATE 60• ASP
Environment Canada Domestic Substance ListSORBITAN, MONOOCTADECANOATE, POLY(OXY-1,2-ETHANEDIYL) DERIVS.,,Low-Health Priority,U-Persistent,U-Bioaccumulative,,,,,
IFRA Fragrance Ingredient ListSORBITAN MONOSTEARATE. ETHOXYLATEDreported as used in fragrance compounds in 2008
FDA Food Additive StatusPOLYETHYLENE GLYCOL• BC
• REG
• GMP
• In boiler water -173.310
• AF
• REG
• GMP
• Comp of defoaming agent -173.340
• CTG
• REG
• GMP
• Ctg on fresh citrus fruits -172.210
FDA Food Additive StatusPOLYETHYLENE GLYCOL• MISC
• REG
• GMP
• Ctg
• binder
• plasticizing agent
• and/or lubricant in tabs used for food
• Adjuvant in nonnutritive sweeteners
• vitamin & mineral prepns
• Ctg for sodium nitrite to inhibit hygroscopic properties - CFR172.820
• ZERO - In milk - CFR172.820; 526.820
Cosmetic Ingredient Review AssessmentsPEG-6QQQ01,QQQ22; I, M-, R-, C-
CIRPEG-6Impurity: 1,4-dioxane, ethylene oxide
Harvell, J, 1994POLYETHYLENE GLYCOLSkin or Sense Organ Toxicity Hazards: suspected

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- "Morphological Precursors of Cancer, Proceedings of an International Conference, Perugia, Italy, 1961," Severi, L 1962POLYSORBATE-60• cancer - Tumors at site of application (rat TDLo)
RTECS®- FAO Nutrition Meetings Report Series 1974POLYSORBATE-60• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Journal of Nutrition 1956POLYSORBATE-60• reproductive - Viability index (rat TDLo)
RTECS®- Journal of the American Pharmaceutical Association, Scientific Edition 1956POLYSORBATE-60• broad systemic - Broad systemic toxicity (mouse LDLo)
RTECS®- Journal of the National Cancer Institute 1960POLYSORBATE-60• cancer - skin tumor formations - equivocal (mouse TDLo)
• cancer - Tumors at site of application (mouse TDLo)
RTECS®- National Technical Information Service 7605POLYSORBATE-60• reproductive - Growth statistics (mouse TDLo)
RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis 1987POLYSORBATE-60• reproductive - Growth statistics (mouse TDLo)
RTECS®- Toxicology and Applied Pharmacology 1959POLYSORBATE-60• liver - Changes in liver weight (rat TDLo)
• gastrointestinal - Hypermotility, diarrhea (rat TDLo)
RTECS®- Toxicology and Applied Pharmacology 1965POLYSORBATE-60• blood - Changes in erythrocyte (RBC) count (mouse TDLo)
• blood - Pigmented or nucleated red blood cells (mouse TDLo)

references
government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Impurities - Open Scientific LiteratureCIR
Scorecard.org Toxicity InformationHarvell, J., M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
RTECS®- "Morphological Precursors of Cancer, Proceedings of an International Conference, Perugia, Italy, 1961," Severi, L 1962 [shown for informational purposes only]RTECS®- "Morphological Precursors of Cancer, Proceedings of an International Conference, Perugia, Italy, 1961," Severi, L., ed., Perugia, Univ. of Perugia, 1962 -,83,1962
RTECS®- FAO Nutrition Meetings Report Series 1974 [shown for informational purposes only]RTECS®- FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. 53A,254,1974
RTECS®- Journal of Nutrition 1956 [shown for informational purposes only]RTECS®- Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- -1928 60,489,1956
RTECS®- Journal of the American Pharmaceutical Association, Scientific Edition 1956 [shown for informational purposes only]RTECS®- Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. 45,685,1956
RTECS®- Journal of the National Cancer Institute 1960 [shown for informational purposes only]RTECS®- Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. 25,607,1960
RTECS®- National Technical Information Service 7605 [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB86-197605
RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis 1987 [shown for informational purposes only]RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- 7,29,1987
RTECS®- Toxicology and Applied Pharmacology 1959 [shown for informational purposes only]RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 1,315,1959
RTECS®- Toxicology and Applied Pharmacology 1965 [shown for informational purposes only]RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 7,320,1965

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.