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Score:
Data available:
 
Limited

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PHENOLPHTHALEIN


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
 
Allergies & immunotoxicity
 
 

Function(s): Not Reported

Synoym(s): 1 (3H) -ISOBENZOFURANONE, 3,3-BIS (4-HYDROXYPHENYL) -; 1 (3H) ISOBENZOFURANONE, 3,3BIS (4HYDROXYPHENYL) ; 3,3-BIS (4-HYDROXYPHENYL) PHTHALIDE; 3,3-BIS (4-HYDROXYPHENYL) - 1 (3H) -ISOBENZOFURANONE; 3,3-BIS (4-HYDROXYPHENYL) -1 (3H) -ISOBENZOFURANONE; 1 (3H) -ISOBENZOFURANONE, 3,3-BIS (4-HYDROXYPHENYL) -; 3,3-BIS (4-HYDROXYPHENYL) -1- (3H) -ISOBENZOFURANONE; 3,3-BIS (P-HYDROXYPHENYL) PHTHALIDE; AGORAL; ALOPHEN; ALPHA-DI (P-HYDROXYPHENYL) PHTHALIDE

Use restrictions

Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCosIng

Cancer

Concern Reference
Possible human carcinogenEuropean Union - Classification & Labelling
Possible human carcinogenNTP Report on Carcinogens, 11th Edition
Possible human carcinogenCalifornia EPA Proposition 65
Limited evidence of carcinogenicityInt'l Agency for Research on Cancer (IARC) - Carcinogens

Endocrine disruption

Concern Reference
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption

Developmental/reproductive toxicity

Concern Reference
Limited evidence of reproductive toxicityEuropean Union - Classification & Labelling
Limited evidence of reproductive toxicityChapin, R

Organ system toxicity (non-reproductive)

Concern Reference
Classified as a high human health priorityEnvironment Canada Domestic Substance List
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
865 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data Sources

CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
Chapin, R.E. and R.A. Sloane. NIEHS/NTP Reproductive Assessment by Continuous Breeding: Evolving Study Design and Summaries of Ninety Studies. Environmental Health Perspectives 105, Supplement 1: 199-394. 1997. http://ehpnet1.niehs.nih.gov/docs/1997/Suppl-1/chapin.html
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer