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PHENACETIN


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
Allergies & immunotoxicity
 
 
Use restrictions
 
 

About PHENACETIN: Phenacetin is an aromatic compound.

Function(s): Not Reported; STABILISING

Synonym(s): ACETAMIDE, N (4ETHOXYPHENYL) ; ACETAMIDE, N- (4-ETHOXYPHENYL) -; ACETOPHENETIDIN; N- (4-ETHOXYPHENYL) - ACETAMIDE; N- (4-ETHOXYPHENYL) ACETAMIDE; N-ACETYL-P-ETHOXYANILINE; 1-ACETAMIDO-4-ETHOXYBENZENE; 4'-ETHOXYACETANILIDE; 4-ETHOXYACETANILIDE; ACET-P-PHENALIDE; ACET-P-PHENETIDIN

Cancer

Concern Reference
Known human carcinogenInt'l Agency for Research on Cancer (IARC) - Carcinogens
Possible human carcinogenNTP Report on Carcinogens, 11th Edition
Possible human carcinogenCalifornia EPA Proposition 65
Cancer - limited evidenceSilent Spring's Mammary Carcinogens Reviews Database

Organ system toxicity (non-reproductive)

Concern Reference
Classified as a high human health priorityEnvironment Canada Domestic Substance List
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Limited evidence of sense organ toxicityLock, E
Limited evidence of cardiovascular or blood toxicityMalachowsky, M

Data gaps

Concern Reference
2,908 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Persistence and bioaccumulation

Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data Sources

California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
Lock, E.A., and E. Harpur. Toxicology of Sensory System: A Perspective. Human and Experimental Toxicology. 11(6): 442-448. 1992. (Table 1: Chemicals that induce olfactory lesions in experimental animals by either inhalation and/or non-inhalation routes).
Malachowsky, M.J. Health Effects of Toxic Substances. Government Institutes. Rockville, MD 1995., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Rudel RA, KR Attfield, JN Schifano and JG Brody. Chemicals Causing Mammary Gland Tumors in Animals Signal New Directions for Epidemiology, Chemicals Testing, and Risk Assessment for Breast Cancer Prevention. CANCER Supplement. 2007 Jun 15;109(12):2635-2666.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer