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PEG-40 STEARATE
Score
Data: Limited
CAS9004-99-3
moisturizer (75 products)
anti-aging (56 products)
facial moisturizer/ treatment (50 products)
mascara (42 products)
around-eye cream (17 products)
Show all 275 products that contain PEG-40 STEARATE.
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PEG-40 STEARATE


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictionsyes
Contamination concerns: ETHYLENE OXIDE, 1,4-DIOXANE
Other MODERATE concerns: Organ system toxicity (non-reproductive)
Other LOW concerns: Ecotoxicology, Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Surfactant - Cleansing Agent; Surfactant - Solubilizing Agent

About PEG-40 STEARATE: PEG-40 stearate is a synthetic polymer composed of PEG (polyethylene glycol) and stearic acid, a naturally occurring fatty acid. Due to the presence of PEG, this ingredient may contain potentially tox ... read more

Synonym(s): MACROGOL STEARATE 2000; POLYETHYLENE GLYCOL 2000 MONOSTEARATE; POLYOXYETHYLENE (40) MONOSTEARATE; POLYOXYL 40 STEARATE; STEARETHATE 40

Use restrictions

type of concern product conditions reference
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin products for use on damaged skin Cosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Limited evidence of sense organ toxicity    Harvell, J, 1994
show more

Ecotoxicology

type of concern product conditions reference
Suspected to be an environmental toxin    Environment Canada Domestic Substance List

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
Safety assessment was based on related chemical   Cosmetic Ingredient Review Assessments
32 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Food Additive Status
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be persistent    Environment Canada Domestic Substance List
show more

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusPOLYOXYETHYLENE (40) MONOSTEARATE• AF
• REG
• Defoaming agent comp - CFR173.34
Cosmetic Ingredient Review AssessmentsPEG-40 STEARATEQQQ01,QQQ11,QQQ37; I, R-
FDA Everything Added to FoodPOLYOXYETHYLENE 40 MONOSTEARATE• ASP
Environment Canada Domestic Substance ListPOLY(OXY-1,2-ETHANEDIYL), _-(1-OXOOCTADECYL)-_-HYDROXY-,,,,,Y-AquaticTox,,,,
IFRA Fragrance Ingredient ListPOLY(OXY-1,2-ETHANEDIYL), A-(1-OXOOCTADECYL)-W-HYDROXY-reported as used in fragrance compounds in 2008
FDA Food Additive StatusPOLYETHYLENE GLYCOL• BC
• REG
• GMP
• In boiler water -173.310
• AF
• REG
• GMP
• Comp of defoaming agent -173.340
• CTG
• REG
• GMP
• Ctg on fresh citrus fruits -172.210
FDA Food Additive StatusPOLYETHYLENE GLYCOL• MISC
• REG
• GMP
• Ctg
• binder
• plasticizing agent
• and/or lubricant in tabs used for food
• Adjuvant in nonnutritive sweeteners
• vitamin & mineral prepns
• Ctg for sodium nitrite to inhibit hygroscopic properties - CFR172.820
• ZERO - In milk - CFR172.820; 526.820
Cosmetic Ingredient Review AssessmentsPEG-6QQQ01,QQQ22; I, M-, R-, C-
CIRPEG-6Impurity: 1,4-dioxane, ethylene oxide
Harvell, J, 1994POLYETHYLENE GLYCOLSkin or Sense Organ Toxicity Hazards: suspected

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Archives of Environmental Health 1963PEG-40 STEARATE• cancer - Tumor types after systemic administration not seen spontaneously (rat TDLo)
• cancer - Tumors at site of application (rat TDLo)
RTECS®- Bollettino Chimico Farmaceutico 1962PEG-40 STEARATE• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Food Research 1956PEG-40 STEARATE• blood - Changes in spleen (hamster TDLo)
• gastrointestinal - Hypermotility, diarrhea (hamster TDLo)
• gastrointestinal - Other changes (hamster TDLo)
RTECS®- Journal of Nutrition 1956PEG-40 STEARATE• reproductive - Viability index (rat TDLo)
RTECS®- Journal of the American College of Toxicology 1983PEG-40 STEARATE• skin - Primary skin irritant (rabbit )
RTECS®- Journal of the American College of Toxicology 1983PEG-40 STEARATE• skin - Primary skin irritant (rabbit )
RTECS®- Journal of the American Pharmaceutical Association, Scientific Edition 1949PEG-40 STEARATE• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- National Technical Information Service 4764PEG-40 STEARATE• sense organ - Primary eye irritant (rabbit )
• skin - Primary skin irritant (rabbit )
RTECS®- National Technical Information Service PEG-40 STEARATE• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- National Technical Information Service 4764PEG-40 STEARATE• sense organ - Primary eye irritant (rabbit )
• skin - Primary skin irritant (rabbit )
RTECS®- Toxicology and Applied Pharmacology 1959PEG-40 STEARATE• metabolic - Weight loss or decreased weight gain (rat TDLo)
• gastrointestinal - Hypermotility, diarrhea (rat TDLo)
• metabolic - Other changes (rat TDLo)

references
government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Impurities - Open Scientific LiteratureCIR
Scorecard.org Toxicity InformationHarvell, J., M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
RTECS®- Archives of Environmental Health 1963 [shown for informational purposes only]RTECS®- Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- 6,484,1963
RTECS®- Bollettino Chimico Farmaceutico 1962 [shown for informational purposes only]RTECS®- Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- 101,173,1962
RTECS®- Food Research 1956 [shown for informational purposes only]RTECS®- Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. 21,348,1956
RTECS®- Journal of Nutrition 1956 [shown for informational purposes only]RTECS®- Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- -1928 60,489,1956
RTECS®- Journal of the American College of Toxicology 1983 [shown for informational purposes only]RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 2(7),17,1983
RTECS®- Journal of the American College of Toxicology 1983 [shown for informational purposes only]RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 2(7),17,1983
RTECS®- Journal of the American Pharmaceutical Association, Scientific Edition 1949 [shown for informational purposes only]RTECS®- Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. 38,428,1949
RTECS®- National Technical Information Service 4764 [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0534764
RTECS®- National Technical Information Service [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD277-689
RTECS®- National Technical Information Service 4764 [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0534764
RTECS®- Toxicology and Applied Pharmacology 1959 [shown for informational purposes only]RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 1,315,1959

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.