PARACYMENE || Skin Deep® Cosmetics Database | Environmental Working Group

PARACYMENE

Score	Data: Limited
CAS	99-87-6
fragrance for women (8 products)
fragrance for men (3 products)
pain relief (2 products)
muscle/ joint soreness (1 products)
Show all 13 products that contain PARACYMENE.
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PARACYMENE

image source: PubChem

Health concerns of ingredient
About the ratings
Cancer	no information
Developmental & reproductive toxicity	no information
Allergies & immunotoxicity	no information
Use restrictions	no information
Contamination concerns: none
Other MODERATE concerns: Neurotoxicity
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Fragrance Ingredient; MASKING

About PARACYMENE: p-Cymene is an aromatic hydrocarbon.

Synonym(s): p-CYMENE, BENZENE, 1-METHYL-4- (1-METHYLETHYL) -; PARA-CYMENE; 1-METHYL-4-ISOPROPYLBENZENE; 1-METHYL-4- (1-METHYLETHYL) BENZENE; 1-METHYL-4- (1-METHYLETHYL) - BENZENE; BENZENE, 1METHYL4 (1METHYLETHYL) ; 1-METHYL-4-ISOPROPYLBENZENE; 4-ISOPROPYL-1-METHYLBENZENE; BENZENE, 1-ISOPROPYL-4-METHYL-; CAMPHOGEN; CUMENE, P-METHYL-

Neurotoxicity
type of concern	product conditions	reference
Limited evidence of toxicity		Lam HR, Ladefoged O, Ostergaard G, Lund SP, Simonsen L, 1996

Data gaps
type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
666 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Ecotoxicology
type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Classified as not expected to be potentially toxic or harmful

Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be bioaccumulative

Environment Canada Domestic Substance List

Multiple, additive exposure sources
type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Everything Added to Food

Government, industry, academic studies and classifications
government/industry list/academic study	appears on list as	classification(s)
FDA Everything Added to Food	P-CYMENE	• ASP
Environment Canada Domestic Substance List	BENZENE, 1-METHYL-4-(1-METHYLETHYL)-	,,Low-Health Priority,,,,,,,
IFRA Fragrance Ingredient List	P-CYMENE	reported as used in fragrance compounds in 2008
Lam HR, Ladefoged O, Ostergaard G, Lund SP, Simonsen L, 1996	P-CYMENE	Inhalation exposure to p-cymene in laboratory animals was associated with neurotoxicity (reduced density and number of synapses).

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study	appears on list as	classification(s)
RTECS^®- "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov" 1990	PARACYMENE	• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS^®- Food and Cosmetics Toxicology 1974	PARACYMENE	• skin - Primary skin irritant (rabbit )
RTECS^®- Food and Cosmetics Toxicology 1964	PARACYMENE	• sense organ - Chromodacyrorrhea (rat LD50) • gastrointestinal - Hypermotility, diarrhea (rat LD50) • brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (rat LD50)

references
government/industry list/academic study	reference
FDA Everything Added to Food	FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Open scientific literature	Lam HR, Ladefoged O, Ostergaard G, Lund SP, Simonsen L. 1996. Four weeks
RTECS^®- "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov" 1990 [shown for informational purposes only]	RTECS^®- "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990. -,180,1990
RTECS^®- Food and Cosmetics Toxicology 1974 [shown for informational purposes only]	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 12,401,1974
RTECS^®- Food and Cosmetics Toxicology 1964 [shown for informational purposes only]	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 2,327,1964