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P-AMINOPHENOL


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
 

About P-AMINOPHENOL: p-aminophenol is a synthetic dye used in hair coloring; produced from coal tar.

Function(s): Hair Colorant; HAIR DYEING

Synonym(s): p-AMINOPHENOL, 4-AMINO- PHENOL; 4-AMINO-1-HYDROXYBENZENE; 4-AMINOPHENOL; 4-HYDROXYANILINE; 4-HYDROXYBENZENAMINE; 4-HYDROXYPHENYLAMINE; CI 76550; P-AMINO- PHENOL; PHENOL, 4-AMINO-; PHENOL, 4AMINO; PHENOL, P-AMINO-

Allergies/immunotoxicity

Concern Reference
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Human skin toxicant or allergen - strong evidence
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Health Canada
Determined safe for use in cosmetics, subject to concentration or use limitations - CTFA International Cosmetic Ingredient Dictionary and Handbook

Organ system toxicity (non-reproductive)

Concern Reference
Classified as a high human health priorityEnvironment Canada Domestic Substance List
Classified as toxic or harmful (only for products for use around the mouth; products for use on the lips; products that may be aerosolized (airborne))European Union - Classification & Labelling
Limited evidence of cardiovascular or blood toxicityNational Library of Medicine HazMap
Limited evidence of kidney toxicityKlaassen, C
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Occupational hazards

Concern Reference
Allowed workplace exposures restricted to low dosesEuropean Union - Classification & Labelling
Limited evidence of occupational hazardsEuropean Union - Classification & Labelling

Cancer

Concern Reference
Cancer - limited evidence
Cancer - limited evidenceCTFA International Cosmetic Ingredient Dictionary and Handbook
Mutagen - limited evidenceEuropean Union - Classification & Labelling

Ecotoxicology

Concern Reference
Wildlife and environmental toxicityEuropean Union - Classification & Labelling
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
Insufficient data to determine safetyCosmetic Ingredient Review Assessments
1,215 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CIR
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Health Canada. 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2011.
Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer