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Data available:
 
Fair

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OCTOCRYLENE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
Allergies & immunotoxicity
 
 
Other HIGH concerns: Biochemical or cellular level changes; Other MODERATE concerns: Persistence and bioaccumulation; Other LOW concerns: Ecotoxicology, Irritation (skin, eyes, or lungs)

About OCTOCRYLENE: Octocrylene is a common sunscreen ingredient. It may cause allergic skin reactions in sensitive individuals.

Function(s): Sunscreen Agent; Ultraviolet Light Absorber; UV ABSORBER; UV FILTER

Synonym(s): 2-CYANO-3,3-DIPHENYL ACRYLIC ACID, 2-ETHYLHEXYL ESTER; 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYL-2-ACRYLATE; 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYL-2-PROPENOATE; 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYLACRYLATE; 2-ETHYLHEXYL 2-CYANO-3-PHENYLCINNAMATE; 2-ETHYLHEXYL ESTER 2-CYANO-3,3-DIPHENYL ACRYLIC ACID; 2-ETHYLHEXYL-2-CYANO-3,3-DIPHENYLACRYLATE; 2PROPENOIC ACID, 2CYANO3,3DIPHENYL, 2ETHYLHEXYL ESTER; CCRIS 4814; EINECS 228-250-8; OC

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)Japan's Standards for Cosmetics

Biochemical or cellular level changes

Concern Reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.Hanson KM, Gratton E, Bardeen CJ

Persistence and bioaccumulation

Concern Reference
Ingredient is suspected or measured to accumulate in peopleSchlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al
Found to be persistent and bioaccumulative in wildlifeBuser HR, Balmer ME, Schmid P, Kohler M
Not suspected to be persistentEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

Concern Reference
Limited evidence of skin irritationde Groot AC, Roberts DW

Ecotoxicology

Concern Reference
Wildlife and environmental toxicityBuser H-R, Balmer ME, Schmid P, Kohler M
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
14,937 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Enhanced skin absorption

Concern Reference
Absorbs into the skin

Data Sources

Buser H-R, Balmer ME, Schmid P, Kohler M. 2006. Occurrence of UV Filters 4-Methylbenzylidene Camphor andOctocrylene in Fish from Various Swiss Rivers with Inputs from Wastewater Treatment Plants. ES&T. 40:1427-1431.
Buser HR, Balmer ME, Schmid P, Kohler M. 2006. Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various swiss rivers with inputs from wastewater treatment plants. Environmental Science & Technology 40(5): 1427-1431.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Hanson KM, Gratton E, Bardeen CJ. 2006. Sunscreen enhancement of UV-induced reactive oxygen species in the skin. Free Radic Biol Med 41(8): 1205-1212.
Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Schlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al. 2008. Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk. Chimia 62: 1-7.
de Groot AC, Roberts DW. 2014. Contact and photocontact allergy to octocrylene: a review. Contact Dermatitis. 70(14):193-204.
{Allen, 1996}
{Hayden, 2005; Potard, 2000}

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EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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