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OCTOCRYLENE
Score
Data: Fair
CAS6197-30-4
sunscreen: SPF greater than 30 (256 products)
sunscreen: SPF 15-30 (100 products)
sunscreen: moisturizer (78 products)
anti-aging (32 products)
baby sunscreen (29 products)
Show all 360 products that contain OCTOCRYLENE.
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OCTOCRYLENE


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictionsyes
Contamination concerns: none
Other HIGH concerns: Biochemical or cellular level changes
Other MODERATE concerns: Persistence and bioaccumulation
Other LOW concerns: Ecotoxicology, Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Sunscreen Agent; Ultraviolet Light Absorber; UV ABSORBER; UV FILTER

About OCTOCRYLENE: Octocrylene is a synthetic UV absorber and sunscreen agent; may be used in combination with other UV absorbers to achieve higher SPF formulas. It produces oxygen radicals when exposed to UV light.

Synonym(s): 2-CYANO-3,3-DIPHENYL ACRYLIC ACID, 2-ETHYLHEXYL ESTER; 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYLACRYLATE; 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYL-2-PROPENOATE; 2-ETHYLHEXYL 2-CYANO-3-PHENYLCINNAMATE; UV ABSORBER-3; 2-ETHYLHEXYL ESTER 2-CYANO-3,3-DIPHENYL ACRYLIC ACID; 2PROPENOIC ACID, 2CYANO3,3DIPHENYL, 2ETHYLHEXYL ESTER; OCTOCRILENE; OC; 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYL-2-ACRYLATE; 2-ETHYLHEXYL-2-CYANO-3,3-DIPHENYLACRYLATE

Use restrictions

type of concern product conditions reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)   Japan's Standards for Cosmetics

Biochemical or cellular level changes

type of concern product conditions reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.    Allen, 1996
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.    Hanson KM, Gratton E, Bardeen CJ, 2006

Persistence and bioaccumulation

type of concern product conditions reference
Ingredient is suspected or measured to accumulate in people    Schlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al, 2008
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Ecotoxicology

type of concern product conditions reference
Wildlife and environmental toxicity    Buser H-R, Balmer ME, Schmid P, Kohler M, 2006
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Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
12,067 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List

Enhanced skin absorption

type of concern product conditions reference
Absorbs into the skin    Hayden, 2005; Potard, 2000

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
Environment Canada Domestic Substance List2-PROPENOIC ACID, 2-CYANO-3,3-DIPHENYL-, 2-ETHYLHEXYL ESTER,,,,Y-Bioaccumulative,,,,,
Japan's Standards for Cosmetics2-CYANO-3,3-DIPHENYL PROP-2-ENOIC ACID 2-ETHYLHEXYL ESTER (OCTOCRYLENE)Japan - restricted for use in cosmetics (concentration limit)
Allen, 1996OCTOCRYLENEProduces damaging reactive oxygen species upon exposure to sunlight
Hayden, 2005; Potard, 2000OCTOCRYLENEAbsorbed through human skin in vitro at 0 to 0.25%
Hanson KM, Gratton E, Bardeen CJ, 2006OCTOCRYLENEWhen octocrylene penetrates into the skin, the level of reactive oxygen species increases above that produced naturally under UV illumination
Buser HR, Balmer ME, Schmid P, Kohler M, 2006OCTOCRYLENEFound to accumulate in fish living downstream of wastewater treatment plants
Buser H-R, Balmer ME, Schmid P, Kohler M, 2006OCTOCRYLENEAccumulation in fish in Swiss rivers downstream from Wastewater Treatment Plants.
Schlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al, 2008OCTOCRYLENE

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- National Technical Information Service 6792OCTOCRYLENE• liver - Changes in liver weight (rat TDLo)
• blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo)
• liver - Liver function tests impaired (rat TDLo)

references
government/industry list/academic study reference
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
Japan's Standards for CosmeticsJapan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
Open scientific literature{Allen, 1996}
Open scientific literature{Hayden, 2005; Potard, 2000}
Open scientific literatureHanson KM, Gratton E, Bardeen CJ. 2006. Sunscreen enhancement of UV-induced reactive oxygen species in the skin. Free Radic Biol Med 41(8): 1205-1212.
Open scientific literatureBuser HR, Balmer ME, Schmid P, Kohler M. 2006. Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various swiss rivers with inputs from wastewater treatment plants. Environmental Science & Technology 40(5): 1427-1431.
Open scientific literatureBuser H-R, Balmer ME, Schmid P, Kohler M. 2006. Occurrence of UV Filters 4-Methylbenzylidene Camphor andOctocrylene in Fish from Various Swiss Rivers with Inputs from Wastewater Treatment Plants. ES&T. 40:1427-1431.
Open scientific literatureSchlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al. 2008. Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk. Chimia 62: 1-7.
RTECS®- National Technical Information Service 6792 [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0556792

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.