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OCTISALATE

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Allergies/immunotoxicity

Concern Reference
One or more human case studies show possible immune or allergenic effectsShaw DW
One or more human case studies show possible immune or allergenic effectsSingh M, Beck MH

Ecotoxicology

Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Enhanced skin absorption

Concern Reference
Penetration enhancer
Absorbs into the skinWalters KA, Brain KR, Howes D, James VJ, Kraus AL, Teetsel NM, et al

Data gaps

Concern Reference
1,896 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Biochemical or cellular level changes

Concern Reference
Does not produces excess reactive oxygen species or other harmful biochemical changes.

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data Sources

EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Shaw DW. 2006. Allergic contact dermatitis from octisalate and cis-3-hexenyl salicylate. Dermatitis 17(3): 152-155.
Singh M, Beck MH. 2007. Octyl salicylate: a new contact sensitivity. Contact Dermatitis 56(1): 48.
Walters KA, Brain KR, Howes D, James VJ, Kraus AL, Teetsel NM, et al. 1997. Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro. Food Chem Toxicol 35(12): 1219-1225.
{Allen, 1996}
{Krishnan, 2004}
{Morgan, 1998}
{Pont, 2004}

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer