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NIACINAMIDE
Score
Data: Fair
CAS98-92-0
facial moisturizer/ treatment (130 products)
anti-aging (83 products)
conditioner (61 products)
shampoo (46 products)
hair color and bleaching (36 products)
Show all 469 products that contain NIACINAMIDE.
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NIACINAMIDE


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Hair Conditioning Agent; Skin-Conditioning Agent - Miscellaneous; SMOOTHING

About NIACINAMIDE: Niacinamide is a form of vitamin B3(niacin), a water-soluble vitamin; used in cosmetics and personal care products as a conditioning agent.

Synonym(s): M- (AMINOCARBONYL) PYRIDINE; 3-AMINOPYRIDINE; 3-CARBAMOYLPYRIDINE; NICOTINAMIDE; NICOTNINIC ACID AMIDE; 3-PYRIDINECARBOXAMIDE; 3PYRIDINECARBOXAMIDE; 3-AMINOPYRIDINE; 3-CARBAMOYLPYRIDINE; 3-PYRIDINAMINE; 3-PYRIDINECARBOXAMIDE

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
49,310 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food
Designated as safe for general or specific, limited use in food   FDA Food Additive Status

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List
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Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List
show more

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusNIACINAMIDE• NUTR/DS
• GRAS/FS -182.5535; 184.1535
• Part 137 (137.165; 137.185; 137.235; 137.260; 137.305; 137.350)
• Cereal Flours
• Part 139 (139.115; 139.117; 139.122; 139.155; 139.165)
• Macaroni & Noodle Pdts
• 136.115
• Enriched Bread
Cosmetic Ingredient Review AssessmentsNIACINAMIDEQQQ01,QQQ11; C+, M+, D-
FDA Everything Added to FoodNIACINAMIDE• ASP
Environment Canada Domestic Substance List3-PYRIDINECARBOXAMIDE,,Low-Health Priority,,,,,,,

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1985NIACINAMIDE• brain, nervous system, or behavioral effect - Anti-convulsant (mouse TDLo)
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1988NIACINAMIDE• biochemical - Dehydrogenases (mouse TDLo)
• endocrine system - Hypoglycemia (mouse TDLo)
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1992NIACINAMIDE• brain, nervous system, or behavioral effect - Anti-convulsant (mouse TDLo)
• brain, nervous system, or behavioral effect - Ataxia (mouse TDLo)
RTECS®- JNCI, Journal of the National Cancer Institute 1982NIACINAMIDE• mutagenic - Positive mutation assay: DNA Inhibition (rat lvr)
RTECS®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho 1986NIACINAMIDE• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho 1986NIACINAMIDE• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- Mutagenesis 2002NIACINAMIDE• broad systemic - Broad systemic toxicity (mouse LDLo)
• mutagenic - Positive mutation assay: Cytogenetic Analysis (mouse ipr)
RTECS®- Mutagenesis 2002NIACINAMIDE• mutagenic - Positive mutation assay: Cytogenetic Analysis (mouse ipr)
RTECS®- Mutation Research 1984NIACINAMIDE• mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster ovr)
RTECS®- Mutation Research 1985NIACINAMIDE• mutagenic - Positive mutation assay: body fluid assay (rat )
RTECS®- Mutation Research 1984NIACINAMIDE• mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster ovr)
RTECS®- Mutation Research 1985NIACINAMIDE• mutagenic - Positive mutation assay: body fluid assay (rat )
RTECS®- Nucleus (Calcutta) 1985NIACINAMIDE• mutagenic - Positive mutation assay: Sister Chromatid Exchange ( human lym)
RTECS®- Nucleus (Calcutta) 1985NIACINAMIDE• mutagenic - Positive mutation assay: Sister Chromatid Exchange ( human lym)
RTECS®- Pharmaceutical Chemistry Journal (English Translation) 1986NIACINAMIDE• broad systemic - Broad systemic toxicity (mammal LD50)
RTECS®- Proceedings of the Society for Experimental Biology and Medicine 1946NIACINAMIDE• respiratory - Other changes (rat LD50)
RTECS®- Quarterly Journal of Pharmacy & Pharmacology 1946NIACINAMIDE• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Radiation Research 1987NIACINAMIDE• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Toksikologicheskii Vestnik 1997NIACINAMIDE• blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo)
• biochemical - Multiple enzyme effects (rat TDLo)
• liver - Other changes (rat TDLo)
RTECS®- United States Patent Document 5129NIACINAMIDE• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Wold Intellectual Property Organization, International bureau; International Application Published Under The Patent Cooperation Treaty #2004000333NIACINAMIDE• biochemical - Effect on inflammation or mediation of inflammation (mouse TDLo)

references
government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1985 [shown for informational purposes only]RTECS®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 48,21,1985
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1988 [shown for informational purposes only]RTECS®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 51,51,1988
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1992 [shown for informational purposes only]RTECS®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 55,27,1992
RTECS®- JNCI, Journal of the National Cancer Institute 1982 [shown for informational purposes only]RTECS®- JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. 69,1353,1982
RTECS®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho 1986 [shown for informational purposes only]RTECS®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- 37,447,1986
RTECS®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho 1986 [shown for informational purposes only]RTECS®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 37,447,1986
RTECS®- Mutagenesis 2002 [shown for informational purposes only]RTECS®- Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- 17,1,2002
RTECS®- Mutagenesis 2002 [shown for informational purposes only]RTECS®- Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 17,1,2002
RTECS®- Mutation Research 1984 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 126,63,1984
RTECS®- Mutation Research 1985 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 143,263,1985
RTECS®- Mutation Research 1984 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 126,63,1984
RTECS®- Mutation Research 1985 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 143,263,1985
RTECS®- Nucleus (Calcutta) 1985 [shown for informational purposes only]RTECS®- Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- 28,198,1985
RTECS®- Nucleus (Calcutta) 1985 [shown for informational purposes only]RTECS®- Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 28,198,1985
RTECS®- Pharmaceutical Chemistry Journal (English Translation) 1986 [shown for informational purposes only]RTECS®- Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- 20,29,1986
RTECS®- Proceedings of the Society for Experimental Biology and Medicine 1946 [shown for informational purposes only]RTECS®- Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- 62,19,1946
RTECS®- Quarterly Journal of Pharmacy & Pharmacology 1946 [shown for informational purposes only]RTECS®- Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. 19,48,1946
RTECS®- Radiation Research 1987 [shown for informational purposes only]RTECS®- Radiation Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1954- 109,479,1987
RTECS®- Toksikologicheskii Vestnik 1997 [shown for informational purposes only]RTECS®- Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown (3),36,1997
RTECS®- United States Patent Document 5129 [shown for informational purposes only]RTECS®- United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) #6365129
RTECS®- Wold Intellectual Property Organization, International bureau; International Application Published Under The Patent Cooperation Treaty #2004000333 [shown for informational purposes only]RTECS®- Wold Intellectual Property Organization, International bureau; International Application Published Under The Patent Cooperation Treaty #2004000333

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