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NIACIN
Score
Data: Fair
CAS59-67-6
lip plumper (25 products)
lip gloss (10 products)
shampoo (10 products)
anti-aging (7 products)
facial moisturizer/ treatment (7 products)
Show all 56 products that contain NIACIN.
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NIACIN


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Hair Conditioning Agent; Skin-Conditioning Agent - Miscellaneous; ANTISTATIC; SMOOTHING

About NIACIN: Niacin is a heterocyclic aromatic compound.

Synonym(s): 3-CARBOXYPYRIDINE; NICOTINIC ACID; 3-PYRIDINECARBOXYLIC ACID; 3PYRIDINECARBOXYLIC ACID; 3-CARBOXYPYRIDINE; 3-PYRIDINECARBOXYLIC ACID; ACIDE NICOTINIQUE (FRENCH) ; ACIDUM NICOTINICUM; AKOTIN; ANTI-PELLAGRA VITAMIN; APELAGRIN

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
17,396 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food
Designated as safe for general or specific, limited use in food   FDA Food Additive Status

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List
show more

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusNIACIN• NUTR/DS
• GRAS/FS - CFR182.5530; 184.1530
• Part 137 (137.165; 137.185; 137.235; 137.260; 137.305; 137.350) Cereal Flours
• Part 139 (139.115; 139.117; 139.122; 139.155; 139.165)
• Macaroni & Noodle Pdts
• 136.115
• Enriched Bread
Cosmetic Ingredient Review AssessmentsNIACINQQQ01,QQQ11; C+, M+
FDA Everything Added to FoodNIACIN• ASP
Environment Canada Domestic Substance List3-PYRIDINECARBOXYLIC ACID,,,,,,,,,

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Biochemical Pharmacology 2002NIACIN• metabolic - Weight loss or decreased weight gain (mouse TDLo)
• blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (mouse TDLo)
• biochemical - Lipids, including transport (mouse TDLo)
• respiratory - Other changes (mouse TDLo)
• biochemical - Other proteins (mouse TDLo)
RTECS®- Biochemical Pharmacology 2003NIACIN• metabolic - Weight loss or decreased weight gain (mouse TDLo)
RTECS®- Brazilian Journal of Medical and Biological Research 2001NIACIN• blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) ( human TDLo)
• biochemical - Lipids, including transport ( human TDLo)
RTECS®- British UK Patent Application 1937NIACIN• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Drugs in Japan (Ethical Drugs) 1982NIACIN• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1984NIACIN• biochemical - Effect on inflammation or mediation of inflammation (mouse TDLo)
RTECS®- Journal of Pharmacology and Experimental Therapeutics 2000NIACIN• biochemical - Effect on inflammation or mediation of inflammation (mouse TDLo)
RTECS®- Oyo Yakuri 1977NIACIN• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Oyo Yakuri 1973NIACIN• brain, nervous system, or behavioral effect - Changes in motor activity (specific assay) (mouse LD50)
• respiratory - Other changes (mouse LD50)
RTECS®- Proceedings of the Society for Experimental Biology and Medicine 1938NIACIN• brain, nervous system, or behavioral effect - Convulsions or effect on seizure threshold (rat LDLo)
RTECS®- Therapie 1971NIACIN• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- United States Patent Document 2998NIACIN• broad systemic - Broad systemic toxicity (rat LD50)

references
government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
RTECS®- Biochemical Pharmacology 2002 [shown for informational purposes only]RTECS®- Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- 64,41,2002
RTECS®- Biochemical Pharmacology 2003 [shown for informational purposes only]RTECS®- Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- 66,393,2003
RTECS®- Brazilian Journal of Medical and Biological Research 2001 [shown for informational purposes only]RTECS®- Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- 34,177,2001
RTECS®- British UK Patent Application 1937 [shown for informational purposes only]RTECS®- British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) #2041937
RTECS®- Drugs in Japan (Ethical Drugs) 1982 [shown for informational purposes only]RTECS®- Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) 6,544,1982
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1984 [shown for informational purposes only]RTECS®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 47,84,1984
RTECS®- Journal of Pharmacology and Experimental Therapeutics 2000 [shown for informational purposes only]RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 293,82,2000
RTECS®- Oyo Yakuri 1977 [shown for informational purposes only]RTECS®- Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- -1967 14,741,1977
RTECS®- Oyo Yakuri 1973 [shown for informational purposes only]RTECS®- Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- -1967 7,149,1973
RTECS®- Proceedings of the Society for Experimental Biology and Medicine 1938 [shown for informational purposes only]RTECS®- Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- 38,241,1938
RTECS®- Therapie 1971 [shown for informational purposes only]RTECS®- Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- 26,831,1971
RTECS®- United States Patent Document 2998 [shown for informational purposes only]RTECS®- United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) #4412998

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