METHYLISOTHIAZOLINONE || Skin Deep® Cosmetics Database

METHYLISOTHIAZOLINONE

Score	Data: Fair
CAS	2682-20-4
shampoo (513 products)
conditioner (373 products)
hair color and bleaching (290 products)
body wash/ cleanser (229 products)
moisturizer (74 products)
Show all 1,518 products that contain METHYLISOTHIAZOLINONE.
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METHYLISOTHIAZOLINONE

image source: PubChem

Health concerns of ingredient
About the ratings
Cancer	no information
Developmental & reproductive toxicity	no information
Allergies & immunotoxicity
Use restrictions
Contamination concerns: none
Other LOW concerns: Neurotoxicity

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Preservative

About METHYLISOTHIAZOLINONE: Methylisothiazolinone is a widely-used preservative; has been associated with allergic reactions. Lab studies on the brain cells of mammals also suggest that methylisothiazolinone may be neurotoxic.

Synonym(s): 3 (2H) -ISOTHIAZOLONE, 2-METHYL-; METHYLCHLOROISOTHIAZOLINONE225METHYLISOTHIAZOLINONE SOLUTION; 2-METHYL-3 (2H) -ISOTHIAZOLONE; 2-METHYL-4-ISOTHIAZOLIN-3-ONE; 2-METHYL- 3 (2H) -ISOTHIAZOLONE; 2-METHYL-2H-ISOTHIAZOL-3-ONE; 3 (2H) ISOTHIAZOLONE, 2METHYL; 2-METHYL-3 (2H) -ISOTHIAZOLONE; 2-METHYL-4-ISOTHIAZOLIN-3-ONE

Allergies/immunotoxicity
type of concern	product conditions	reference
Known human immune system toxicant		National Library of Medicine HazMap
Human skin toxicant - strong evidence		Cosmetic Ingredient Review Assessments
Human skin toxicant - strong evidence
Limited evidence of immune system toxicity		A Relational Database of Hazardous Chemicals and Occupational Diseases, 1991

Use restrictions
type of concern	product conditions	reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		Canada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s)		Japan's Standards for Cosmetics
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		Cosmetic Ingredient Review Assessments

Neurotoxicity
type of concern	product conditions	reference
One or more in vitro tests on mammalian cells demonstrate neurotoxicity		Du S, McLaughlin BA, Pal S, AizenmanIn E, 2002

Data gaps
type of concern	product conditions	reference
180 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Organ system toxicity (non-reproductive)
type of concern	product conditions	reference
Classified as not expected to be potentially toxic or harmful		Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be bioaccumulative

Environment Canada Domestic Substance List

Ecotoxicology
type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study	appears on list as	classification(s)
Canada - Prohibited and Restricted Cosmetics Ingredients	METHYLISOTHIAZOLINONE	Restricted
Cosmetic Ingredient Review Assessments	METHYLISOTHIAZOLINONE	QQQ02,QQQ07; R+, D+, M+, C-, S
Environment Canada Domestic Substance List	3(2H)-ISOTHIAZOLONE, 2-METHYL-	,,,,,,,,,
IFRA Fragrance Ingredient List	2 - METHYL - 2H - ISOTHIAZOL - 3 - ONE	reported as used in fragrance compounds in 2008
National Library of Medicine HazMap	METHYLISOTHIAZOLINONE	SS: Yes;
Japan's Standards for Cosmetics	METHYL ISOTHIAZOLINONE	Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s)
Du S, McLaughlin BA, Pal S, AizenmanIn E, 2002	METHYLISOTHIAZOLINONE	In-vitro study demonstrates this common biocide is highly toxic to neurons.
A Relational Database of Hazardous Chemicals and Occupational Diseases, 1991	METHYL-4-ISOTHIAZOLIN	Immunotoxicity Hazards: suspected

references
government/industry list/academic study	reference
Canada - Prohibited and Restricted Cosmetics Ingredients	Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environment Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
National Library of Medicine HazMap	NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Japan's Standards for Cosmetics	Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
Open scientific literature	Du S, McLaughlin BA, Pal S, AizenmanIn E. 2002. In Vitro Neurotoxicity of Methylisothiazolinone, a Commonly Used Industrial and Household Biocide, Proceeds via a Zinc and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent Pathway. The Journal of Neuroscience, September 1, 2002, 22(17):7408-7416.
Scorecard.org Toxicity Information	A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, Nordic Council of Ministers (Nordic Allergy Project). Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.