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METHYLCHLOROISOTHIAZOLINONE
Score
Data: Fair
CAS26172-55-4
shampoo (514 products)
conditioner (375 products)
hair color and bleaching (290 products)
body wash/ cleanser (221 products)
dandruff/ scalp treatment (55 products)
Show all 1,408 products that contain METHYLCHLOROISOTHIAZOLINONE.
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METHYLCHLOROISOTHIAZOLINONE


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicityyes
Use restrictionsyes
Contamination concerns: none

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Preservative

About METHYLCHLOROISOTHIAZOLINONE: Methylchloroisothiazolinone is a widely-used preservative; has been associated with allergic reactions.

Synonym(s): 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE; 4-ISOTHIAZOLIN-3-ONE, 5-CHLORO-2-METHYL-; 5-CHLORO-2-METHYL- 4-ISOTHIAZOLIN-3-ONE; METHYLCHLOROTHIAZOLINONE; 3 (2H) ISOTHIAZOLONE, 5CHLORO2METHYL; 5-CHLORO-2-METHYL-2H-ISOTHIAZOL-3-ONE; 3 (2H) -ISOTHIAZOLONE, 5-CHLORO-2-METHYL-; 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE; KATHON CG 5243

Allergies/immunotoxicity

type of concern product conditions reference
Known human immune system toxicant    National Library of Medicine HazMap
Human skin toxicant - strong evidence    Cosmetic Ingredient Review Assessments
Human immune system toxicant - moderate evidence    National Library of Medicine HazMap
Limited evidence of immune system toxicity    Nordic Council of Ministers (Nordic Allergy Project), 1991

Use restrictions

type of concern product conditions reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics   Canada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s)   Japan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics when combined with certain other ingredients   Japan's Standards for Cosmetics
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications   Cosmetic Ingredient Review Assessments

Data gaps

type of concern product conditions reference
146 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be persistent    Environment Canada Domestic Substance List
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Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
Canada - Prohibited and Restricted Cosmetics IngredientsMETHYLCHLOROISOTHIAZOLINONERestricted
Cosmetic Ingredient Review AssessmentsMETHYLCHLOROISOTHIAZOLINONEQQQ02,QQQ07
Cosmetic Ingredient Review AssessmentsMETHYLCHLOROISOTHIAZOLINONEQQQ02,QQQ07; R+, D+, M+, C-, S
National Library of Medicine HazMapMETHYLCHLORO-ISOTHIAZOLINONEAS: Yes;SS: Yes;
Japan's Standards for CosmeticsMETHYLCHLORO ISOTHIAZOLINONEJapan - concentration limit in some types of cosmetics when combined with certain other ingredient(s)
Japan's Standards for CosmeticsMETHYLCHLORO ISOTHIAZOLINONEJapan - prohibited for use in some types of cosmetics when combined with certain other ingredients
Japan's Standards for CosmeticsMETHYLCHLORO ISOTHIAZOLINONEJapan - prohibited for use in some types of cosmetics when combined with certain other ingredients
Nordic Council of Ministers (Nordic Allergy Project), 19915-KLOR-2-METYL-4-ISOTIAZOLIN-3-ON OCH 2-METYL-4-ISOTIAZOLIN-3-ON (I FÖRHÅLLANDE 3:1) >15PPMImmunotoxicity Hazards: suspected
Environment Canada Domestic Substance List3(2H)-ISOTHIAZOLONE, 5-CHLORO-2-METHYL-,,,,,,,,,
IFRA Fragrance Ingredient List3(2H)-ISOTHIAZOLONE, 5-CHLORO-2-METHYL-reported as used in fragrance compounds in 2008

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Mutation Research 1983METHYLCHLOROISOTHIAZOLINONE• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- Mutation Research 1983METHYLCHLOROISOTHIAZOLINONE• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )

references
government/industry list/academic study reference
Canada - Prohibited and Restricted Cosmetics IngredientsHealth Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Japan's Standards for CosmeticsJapan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
Scorecard.org Toxicity InformationNordic Council of Ministers (Nordic Allergy Project). Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.; Swedish National Chemicals Inspectorate. Labelling of chemical products, Swedish regulations and general advice with regard to the classification and labelling of chemical products hazardous to health, flammables and explosives. List of Allergenic Substances. National Chemicals Inspectorate, Solna, Sweden. 1987, 1990-1992.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS®- Mutation Research 1983 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 118,129,1983
RTECS®- Mutation Research 1983 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 118,129,1983

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.