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METHOXYISOPROPANOL


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
 
Allergies & immunotoxicity
 
 
Other HIGH concerns: Irritation (skin, eyes, or lungs); Other LOW concerns: Data gaps, Organ system toxicity (non-reproductive)

About METHOXYISOPROPANOL: Methoxyisopropanol is an aliphatic ether alcohol.

Function(s): Fragrance Ingredient; Solvent; Viscosity Decreasing Agent; PERFUMING

Synonym(s): 1-METHOXY- 2-PROPANOL; 1-METHOXY-2-HYDROXYPROPANE; 1-METHOXY-2-PROPANOL; 1-METHOXYPROPAN-2-OL; 2-PROPANOL, 1-METHOXY-; 2PROPANOL, 1METHOXY; PROPYLENE GLYCOL 1-METHYL ETHER; PROPYLENE GLYCOL MONOMETHYL ETHER; 1-METHOXY-2-PROPANOL; ALPHA-PROPYLENE GLYCOL MONOMETHYL ETHER; DOWANOL 33B

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panelCosmetic Ingredient Review Assessments

Developmental/reproductive toxicity

Concern Reference
Limited evidence of reproductive toxicityNational Library of Medicine HazMap

Organ system toxicity (non-reproductive)

Concern Reference
Limited evidence of kidney toxicityNational Library of Medicine HazMap
Limited evidence of gastrointestinal or liver toxicityCalifornia EPA, Office of Environmental Health Hazard Assessment
One or more animal studies show effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Categorized List of Inert Pesticide Ingredients
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

Concern Reference
Human irritant - strong evidence (only for products for use around the eyes, on the skin, or may be aerosolized (airborne))Cosmetic Ingredient Review Assessments

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
Considered safe based on assumption of low absorptionCosmetic Ingredient Review Assessments
Safety unknown for products that may be inhaled (only for products that may be aerosolized (airborne))Cosmetic Ingredient Review Assessments
155 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Neurotoxicity

Concern Reference
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document 'Determination of Noncancer Chronic Reference Exposure Levels'. Includes all Chronic Reference Exposure Levels (CRELs) adopted by OEHHA as of August 2003 (http://www.oehha.ca.gov/air/chronic_rels/AllChrels.html, plus draft CRELS proposed through March 2004 (http://www.oehha.ca.gov/air/chronic_rels/index.html., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer