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Score:
Data available:
 
Fair

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METHENAMINE (FORMALDEHYDE RELEASER)


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
 
Other HIGH concerns: Chemical release concerns; Other MODERATE concerns: Organ system toxicity (non-reproductive); Other LOW concerns: Data gaps, Occupational hazards

About METHENAMINE (FORMALDEHYDE RELEASER): Methenamine is an antimicrobial preservative that works by forming formaldehyde in cosmetic products. People exposed to such formaldehyde-releasing ingredients may develop a formaldehyde allergy or an ... read more

Function(s): Cosmetic Biocide; PRESERVATIVE

Synoym(s): METHENAMINE, 1,3,5,7-TETRAAZATRICYCLO [3,3,1,1] DECANE; 1,3,5,7TETRAAZATRICYCLO [3.3.1.13,7] DECANE; AMINOFORM; FORMAMINE; HEXAMETHYLENE TETRAMINE; HEXAMETHYLENEAMINE; METHENAMIDE; METHENAMIN; 1,3,5,7-TETRAAZAADAMANTANE; 1,3,5,7-TETRAAZATRICYCLO (3.3.1.1 (SUP 37) ) DECANE; 2-ACETYLIMINO-3-METHYL-DELTA (SUP 4) -1,3,4-THIADIAZOLINE-5-SULFONAMIDE

Allergies/immunotoxicity

Concern Reference
Known human toxicant or allergen
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Human skin toxicant or allergen - strong evidence
One or more human case studies show possible immune and respiratory or allergenic effectsAssociation of Occupational and Environmental Clinics
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Use restrictions

Concern Reference
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR) (only for products that may be aerosolized (airborne))Cosmetic Ingredient Review Assessments
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as medium human health priorityEnvironment Canada Domestic Substance List

Cancer

Concern Reference
Cancer - limited evidenceIARC (International Agency for Research on Cancer)

Miscellaneous

Concern Reference
Occupational hazards related to handlingEuropean Union - Classification & Labelling

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Chemical release concerns

Chemical Score
FORMALDEHYDE
Data: Fair
NITROSAMINES
Data: Fair

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
3,583 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Data Sources

AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Formaldehyde - Global Harmonized System (GHS)
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer