MANGANESE GLUCONATE || Skin Deep® Cosmetics Database

MANGANESE GLUCONATE

Score	Data: Fair
CAS	6485-39-8
anti-aging (10 products)
facial moisturizer/ treatment (10 products)
facial powder (6 products)
concealer (5 products)
around-eye cream (4 products)
Show all 38 products that contain MANGANESE GLUCONATE.
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MANGANESE GLUCONATE

image source: PubChem

Health concerns of ingredient
About the ratings
Cancer	no information
Developmental & reproductive toxicity
Allergies & immunotoxicity	no information
Use restrictions	no information
Contamination concerns: none
Other HIGH concerns: Organ system toxicity (non-reproductive)
Other MODERATE concerns: Neurotoxicity
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Not Reported; SKIN CONDITIONING

About MANGANESE GLUCONATE: Manganese Gluconate is a manganese salt of gluconic acid.

Synonym(s): GLUCONIC ACID, MANGANESE SALT; MANGANESE SALT GLUCONIC ACID; BIS (D-GLUCONATO-O1,O2) MANGANESE; MANGANESE, BIS (DGLUCONATOO1,O2) , (T4)

Neurotoxicity
type of concern	product conditions	reference
Strong evidence of human neurotoxicity		Chemicals known to be neurotoxic to humans

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Known human respiratory toxicant

EPA Hazardous Air Pollutants

Developmental/reproductive toxicity
type of concern	product conditions	reference
Human nervous system toxicant - moderate evidence		Chemicals known to be neurotoxic to humans

Occupational hazards
type of concern	product conditions	reference
Single case study detailing occupational hazards		US EPA, Air Risk Information Support Center

Data gaps
type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
665 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Multiple, additive exposure sources
type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Food Additive Status
Designated as safe for general or specific, limited use in food		FDA Everything Added to Food

Persistence and bioaccumulation
type of concern	product conditions	reference
Not suspected to be bioaccumulative		Environment Canada Domestic Substance List

Ecotoxicology
type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study	appears on list as	classification(s)
FDA Food Additive Status	MANGANESE GLUCONATE	• DS/NUTR • GRAS • GMP -182.5452; 184.1452
FDA Food Additive Status	MANGANESE SALTS	• NUTR/DS • GRAS • In animal feed - CFR582.80
FDA Everything Added to Food	MANGANESE GLUCONATE	• ASP
EPA Hazardous Air Pollutants	MANGANESE COMPOUNDS	Hazardous Air Pollutant
Chemicals known to be neurotoxic to humans	MANGANESE COMPOUNDS	known to be neurotoxic to humans
EPA Toxic Release Inventory PBTs	MANGANESE COMPOUNDS	Toxic under the EPA's Toxics Release Inventory
US EPA, Air Risk Information Support Center	MANGANESE COMPOUNDS	Respiratory Toxicity Hazards: suspected
US EPA, Air Risk Information Support Center	MANGANESE COMPOUNDS	Reproductive Toxicity Hazards: suspected
Environment Canada Domestic Substance List	MANGANESE, BIS(D-GLUCONATO-O1,O2)-, (T-4)-	,,,Y-Persistent,,,,,,

references
government/industry list/academic study	reference
FDA Food Additive Status	FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
FDA Everything Added to Food	FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
EPA Hazardous Air Pollutants	EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
Chemicals known to be neurotoxic to humans	Grandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78.
EPA Toxic Release Inventory PBTs	EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
Scorecard.org Toxicity Information	US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html
Scorecard.org Toxicity Information	US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html
Environment Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.