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image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
Allergies & immunotoxicity
Use restrictions
Other HIGH concerns: Endocrine disruption; Other LOW concerns: Ecotoxicology

About KETOCONAZOLE: Ketoconazole is a heterocyclic compound.

Function(s): Not Reported; ANTIMICROBIAL


Endocrine disruption

Concern Reference
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
Limited evidence of endocrine disruptionNational Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyOur Stolen Future Endocrine Disruptors

Developmental/reproductive toxicity

Concern Reference
Limited evidence of reproductive toxicityEuropean Union - Classification & Labelling


Concern Reference
Wildlife and environmental toxicityEuropean Union - Classification & Labelling
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
28,566 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Colborn T, D Dumanoski, JP Myers. 2006. Widespread Pollutants with Endocrine-disrupting Effects. Updated from original listing in "Our Stolen Future" (1996).
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation., World Wildlife Fund. Our Stolen Future. Widespread Pollutants with Endocrine-disrupting Effects. http://www.ourstolenfuture.org/Basics/chemlist.htm. The WWF list is derived from references detailed at http://www.ourstolenfuture.org/Sources/chemsources.htm and was originally published in: Colborn, T., F.S. vom Saal, and A.M. Soto. Developmental Effects of Endocrine-Disrupting Chemicals In Wildlife and Humans. Environmental Health Perspectives 101(5): 378-384. 1993.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer