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IMIDAZOLIDINYL UREA (FORMALDEHYDE RELEASER)


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
 
Other HIGH concerns: Chemical release concerns; Other LOW concerns: Data gaps

About IMIDAZOLIDINYL UREA (FORMALDEHYDE RELEASER): Imidazolidinyl urea is an antimicrobial preservative that works by forming formaldehyde in cosmetic products. People exposed to such formaldehyde-releasing ingredients may develop a formaldehyde aller ... read more

This ingredient may be derived from animals. From PETA's Caring Consumer: Excreted from urine and other bodily fluids. In deodorants, ammoniated dentifrices, mouthwashes, hair colorings, hand creams, lotions, shampoos, etc. Used to "brown" baked goods, such as pretzels. Der ... read more

Function(s): Preservative

Synonym(s): IMIDAZOLIDINYL UREA, N,N"-METHYLENEBIS [N'- [1- (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL] UREA] ; N,N''-METHYLENEBIS [N'- [3- (HYDROXYMETHYL) -2,5-DIOXOIMIDAZOLIDIN-4-YL] UREA] ; UREA, N,N METHYLENEBIS [N [3 (HYDROXYMETHYL) 2,5DIOXO4IMIDAZOLIDINYL] ; UREA, N,N"-METHYLENEBIS [N'- [1- (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL] -; GERMALL 115; METHANEBIS (N,N'- (5-UREIDO-2,4-DIKETOTETRAHYDROIMIDAZOLE) -N,N-DIMETHYLOL) ; N,N''-METHYLENEBIS (N'- (1- (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL) UREA)

Allergies/immunotoxicity

Concern Reference
Known human toxicant or allergen
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Human toxicant or allergen - strong evidenceDe Groot AC
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Cancer

Concern Reference
Cancer - limited evidenceIARC (International Agency for Research on Cancer)

Use restrictions

Concern Reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Scientific Committee on Cosmetic Products and Non-Food Products (SCCPNP)

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
18 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Chemical release concerns

Chemical Score
FORMALDEHYDE
Data: Fair

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
De Groot AC. 2010. Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Contact Dermatitis, 62: 2–17.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Formaldehyde - Global Harmonized System (GHS)
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99.
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Scientific Committee on Cosmetic Products and Non-Food Products (SCCPNP). 2002. OPINION CONCERNING A CLARIFICATION ON THE FORMALDEHYDE AND PARA-FORMALDEHYDE ENTRY IN DIRECTIVE 76/768/EEC ON COSMETIC PRODUCTS.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer