Health Concerns of the Ingredient:
Overall Hazard
Developmental &
reproductive toxicity
Other LOW concerns: Data gaps, Ecotoxicology, Organ system toxicity (non-reproductive)
About IODOPROPYNYL BUTYLCARBAMATE: Iodopropynyl butylcarbamate is used as a preservative in cosmetic formulations; it is acutely toxic by inhalation and should not be used in products that can be aerosolized or inhaled.
Function(s): PRESERVATIVE
Synoym(s): 3-IODO-2-PROPYNYL BUTYLCARBAMATE; BUTYL-3-IODO-2-PROPYNYL ESTER CARBAMIC ACID; BUTYL-3-IODO-2-PROPYNYLCARBAMATE; BUTYLCARBAMIC ACID, 3-IODO-2-PROPYNYL ESTER; CARBAMIC ACID, BUTYL, 3IODO2PROPYNYL ESTER; CARBAMIC ACID, BUTYL-3-IODO-2-PROPYNYL ESTER; IDOPROPYNL BUTYLCARBAMATE; IODOPROPYL BUTYLCARBAMATE; IODOPROPYNL BUTYLCARBAMATE; IPBC
Use restrictions
| Concern |
Reference |
|---|
| Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR) (only for products that may be aerosolized (airborne)) | Cosmetic Ingredient Review Assessments |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit) | Japan's Standards for Cosmetics |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics | Japan's Standards for Cosmetics |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Allergies/immunotoxicity
| Concern |
Reference |
|---|
| Human toxicant or allergen - strong evidence | Cosmetic Ingredient Review Assessments |
| One or more human case studies show significant immune or allergenic effects | Pazzaglia M, Tosti A |
Organ system toxicity (non-reproductive)
| Concern |
Reference |
|---|
| Limited evidence of gastrointestinal or liver toxicity | US EPA |
| One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) | EPA Toxic Release Inventory PBTs |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Ecotoxicology
| Concern |
Reference |
|---|
| Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern |
Reference |
|---|
| Safety assessment was based on related chemical | Cosmetic Ingredient Review Assessments |
| 41 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | NLM PubMed |
Persistence and bioaccumulation
| Concern |
Reference |
|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
| CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule. |
| European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ . |
| Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau. |
| NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov. |
| Pazzaglia M, Tosti A. 1999. Allergic contact dermatitis from 3-iodo-2-propynyl-butylcarbamate in a cosmetic cream. Contact Dermatitis. 1999 Nov;41(5):290. |
| US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm |
Products Containing the Ingredient
About the ratings
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.
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