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HEXYLENE GLYCOL
Score
Data: Fair
CAS107-41-5
hair color and bleaching (299 products)
eye shadow (61 products)
shampoo (55 products)
facial moisturizer/ treatment (54 products)
facial cleanser (36 products)
Show all 690 products that contain HEXYLENE GLYCOL.
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HEXYLENE GLYCOL


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicityyes
Use restrictions no information
Contamination concerns: none
Other HIGH concerns: Irritation (skin, eyes, or lungs)
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Fragrance Ingredient; Solvent; Viscosity Decreasing Agent; EMULSIFYING; PERFUMING; SKIN CONDITIONING; SURFACTANT

About HEXYLENE GLYCOL: Hexylene glycol is a small molecular weight surfactant.

Synonym(s): 2,4-DIHYDROXY-2-METHYLPENTANE; 2-METHYL-2,4-PENTANDIOL; 2-METHYL-2,4-PENTANEDIOL; MPD; 2,4-PENTANEDIOL, 2-METHYL-; 1,1,3-TRIMETHYLTRIMETHYLENEDIOL; 2-METHYL- 2,4-PENTANEDIOL; HEXYLENE GYCOL; 2,4PENTANEDIOL, 2METHYL; 2-METHYLPENTANE-2,4-DIOL; 2,4-DIHYDROXY-2-METHYLPENTANE

Allergies/immunotoxicity

type of concern product conditions reference
Known human immune system toxicant    National Library of Medicine HazMap

Irritation (skin, eyes, or lungs)

type of concern product conditions reference
Classified as irritant    European Union - Classification & Labelling

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
1,992 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List
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Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be persistent    Environment Canada Domestic Substance List
show more

Neurotoxicity

type of concern product conditions reference
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study    National Library of Medicine HazMap

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
European Union - Classification & Labelling2-METHYLPENTANE-2,4-DIOLXi; R36/38
Association of Occupational and Environmental ClinicsHEXYLENE GLYCOL• o
Cosmetic Ingredient Review AssessmentsHEXYLENE GLYCOLQQQ01,QQQ11; E274
Environment Canada Domestic Substance List2,4-PENTANEDIOL, 2-METHYL-,,Low-Health Priority,,,,,,,
IFRA Fragrance Ingredient List2-METHYL-2,4-PENTANDIOLreported as used in fragrance compounds in 2008
National Library of Medicine HazMapHEXYLENE GLYCOLSD: No;SS: Yes;NT: CNS Solvent Syndrome;CE: 25 ppm;FL: 1: must be preheated;MA: 10 ppm;

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- BIOFAX Industrial Bio-Test Laboratories, Inc 1970HEXYLENE GLYCOL• kidney or renal system - Changes in bladder weight (rat TDLo)
• liver - Changes in liver weight (rat TDLo)
• sense organ - Primary eye irritant (rabbit )
RTECS®- Food and Cosmetics Toxicology 1978HEXYLENE GLYCOL• skin - Primary skin irritant (rabbit )
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1944HEXYLENE GLYCOL• skin - Primary skin irritant (rabbit )
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1944HEXYLENE GLYCOL• skin - Primary skin irritant (rabbit )
RTECS®- Union Carbide Data Sheet 1971HEXYLENE GLYCOL• skin - Primary skin irritant (rabbit )

references
government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Association of Occupational and Environmental ClinicsAOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
RTECS®- BIOFAX Industrial Bio-Test Laboratories, Inc 1970 [shown for informational purposes only]RTECS®- BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) 12-4/1970
RTECS®- Food and Cosmetics Toxicology 1978 [shown for informational purposes only]RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 16,777,1978
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1944 [shown for informational purposes only]RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 82,377,1944
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1944 [shown for informational purposes only]RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 82,377,1944
RTECS®- Union Carbide Data Sheet 1971 [shown for informational purposes only]RTECS®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 11/3/1971

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