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Score:
Data available:
 
Fair

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ETHYLENEDIAMINE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
 
Other MODERATE concerns: Organ system toxicity (non-reproductive); Other LOW concerns: Data gaps, Irritation (skin, eyes, or lungs)

Synonym(s): 1,2ETHANEDIAMINE; 1,2-DIAMINO-ETHAAN (DUTCH) ; 1,2-DIAMINO-ETHANO (ITALIAN) ; 1,2-DIAMINOAETHAN (GERMAN) ; 1,2-DIAMINOETHANE (OSHA) ; 1,2-ETHYLENEDIAMINE; AETHALDIAMIN (GERMAN) ; AETHYLENEDIAMIN (GERMAN) ; DIMETHYLENEDIAMINE; ETHYLEENDIAMINE (DUTCH) ; ETHYLENDIAMINE

Use restrictions

Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients

Allergies/immunotoxicity

Concern Reference
Human immune and respiratory toxicant or allergen - strong evidence (only for AND products that may be aerosolized (airborne))Association of Occupational and Environmental Clinics
Limited evidence of immune system toxicity or allergiesEuropean Economic Community

Organ system toxicity (non-reproductive)

Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Limited evidence of sense organ toxicityEuropean Economic Community

Cancer

Concern Reference
Cancer - not classifiable/not likely to be human carcinogenEPA Integrated Risk Information System (IRIS)

Multiple, additive exposure sources

Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Data gaps

Concern Reference
Insufficient data to determine safetyEPA Integrated Risk Information System (IRIS)
5,616 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Occupational hazards

Concern Reference
Single case study detailing occupational hazardsNational Library of Medicine HazMap

Data Sources

AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
European Economic Community. Sensitizing Substances in the EEC List of Dangerous Substances. Annex I to Council Directive 67/548/EEC. http://www.kemi.se/default_eng.cfm?page=klass_mark/klasshem_eng.htm, A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html
European Economic Community. Sensitizing Substances in the EEC List of Dangerous Substances. Annex I to Council Directive 67/548/EEC. http://www.kemi.se/default_eng.cfm?page=klass_mark/klasshem_eng.htm, A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, Swedish National Chemicals Inspectorate. Labelling of chemical products, Swedish regulations and general advice with regard to the classification and labelling of chemical products hazardous to health, flammables and explosives. List of Allergenic Substances. National Chemicals Inspectorate, Solna, Sweden. 1987, 1990-1992.
FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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