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ETHYL ACETATE
Score
Data: Fair
CAS141-78-6
nail polish (755 products)
nail treatment (46 products)
polish remover (14 products)
moisturizer (3 products)
cuticle treatment (2 products)
Show all 605 products that contain ETHYL ACETATE.
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ETHYL ACETATE


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicityyes
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other HIGH concerns: Irritation (skin, eyes, or lungs)
Other MODERATE concerns: Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Fragrance Ingredient; Solvent; PERFUMING

About ETHYL ACETATE: Ethyl acetate is a widely used synthetic solvent.

Synonym(s): ACETIC ACID, ETHYL ESTER; ETHYL ESTER ACETIC ACID; ACETIC ACID ETHYL ESTER; ACETIC ETHER; ACETIDIN; ACETOXYETHANE; AETHYLACETAT (GERMAN) ; ESSIGESTER (GERMAN) ; ETHYL ACETATE (ACGIH:OSHA) ; ETHYL ACETIC ESTER; ETHYL ETHANOATE

Neurotoxicity

type of concern product conditions reference
Strong evidence of human neurotoxicity    Chemicals known to be neurotoxic to humans
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Developmental/reproductive toxicity

type of concern product conditions reference
Human nervous system toxicant - moderate evidence    Chemicals known to be neurotoxic to humans

Occupational hazards

type of concern product conditions reference
Allowed workplace exposures restricted to moderate doses products that may be aerosolized (airborne)  European Union - Classification & Labelling

Irritation (skin, eyes, or lungs)

type of concern product conditions reference
Classified as irritant    European Union - Classification & Labelling

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Limited evidence of sense organ toxicity    CHE Toxicant and Disease Database
show more

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
7,285 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Miscellaneous

type of concern product conditions reference
Occupational hazards related to handling   European Union - Classification & Labelling

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Food Additive Status
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
European Union - Classification & LabellingETHYL ACETATEF; R11; Xi; R36; R66; R67
FDA Food Additive StatusETHYL ACETATE• SY/FS
• MISC
• REG
• GMP
• GRAS - CFR182.60
• In decaffeination of coffee & tea - CFR173.228
Association of Occupational and Environmental ClinicsETHYL ACETATE• S
Association of Occupational and Environmental ClinicsETHYL ACETATE• S
Association of Occupational and Environmental ClinicsETHYL ACETATE• S
CHE Toxicant and Disease DatabaseETHYL ACETATEColor vision disturbance - Limited
Cosmetic Ingredient Review AssessmentsETHYL ACETATEQQQ01,QQQ11; M-
FDA Everything Added to FoodETHYL ACETATE• ASP
Environment Canada Domestic Substance ListACETIC ACID ETHYL ESTER,,Low-Health Priority,Y-Persistent,,,,,,
IFRA Fragrance Ingredient ListETHYL ACETATEreported as used in fragrance compounds in 2008
National Library of Medicine HazMapETHYL ACETATESD: No;NT: CNS Solvent Syndrome;PE: 400 ppm;RD: 614 ppm;LC: 19672 ppm;TL: 400 ppm;FL: 3: may ignite at ambient temperature;ID: 2000 ppm;OH: 50 ppm;OL: 6.4 ppm;MA: 400 ppm;
Chemicals known to be neurotoxic to humansETHYL ACETATEknown to be neurotoxic to humans

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- TLV/BEI,2006ETHYL ACETATE• occupationally related - ACGIH TLV (human TWA)
RTECS®- TLV/BEI,2007ETHYL ACETATE• occupationally related - ACGIH TLV (human TWA)
RTECS®- Food and Chemical Toxicology 1984ETHYL ACETATE• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr)
RTECS®- Food and Chemical Toxicology 1984ETHYL ACETATE• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr)
RTECS®- Journal of Industrial Hygiene and Toxicology 1943ETHYL ACETATE• sense organ - Primary eye irritant ( human )
RTECS®- MSHA STANDARD-air: 3,102,1971ETHYL ACETATE• occupationally related - MSHA STANDARD-air (human TWA)
RTECS®- Mutation Research 1985ETHYL ACETATE• mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (Saccharomyces cerevisiae )
RTECS®- Mutation Research 1985ETHYL ACETATE• mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (Saccharomyces cerevisiae )
RTECS®- OSHA PEL (Construc): 29,1926 1994ETHYL ACETATE• occupationally related - OSHA PEL (Construc) (human TWA)
RTECS®- OSHA PEL (Fed Cont): 41,50-204 1994ETHYL ACETATE• occupationally related - OSHA PEL (Fed Cont) (human TWA)
RTECS®- OSHA PEL (Gen Indu): 29,1910 1994ETHYL ACETATE• occupationally related - OSHA PEL (Gen Indu) (human TWA)
RTECS®- OSHA PEL (Shipyard): 29,1915 1993ETHYL ACETATE• occupationally related - OSHA PEL (Shipyard) (human TWA)

references
government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Association of Occupational and Environmental ClinicsAOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CHE Toxicant and Disease DatabaseCHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Chemicals known to be neurotoxic to humansGrandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78.
RTECS®- TLV/BEI,2006 [shown for informational purposes only]RTECS®- TLV/BEI,2006
RTECS®- TLV/BEI,2007 [shown for informational purposes only]RTECS®- TLV/BEI,2007
RTECS®- Food and Chemical Toxicology 1984 [shown for informational purposes only]RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 22,623,1984
RTECS®- Food and Chemical Toxicology 1984 [shown for informational purposes only]RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 22,623,1984
RTECS®- Journal of Industrial Hygiene and Toxicology 1943 [shown for informational purposes only]RTECS®- Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. 25,282,1943
RTECS®- MSHA STANDARD-air: 3,102,1971 [shown for informational purposes only]RTECS®- MSHA STANDARD-air: 3,102,1971
RTECS®- Mutation Research 1985 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 149,339,1985
RTECS®- Mutation Research 1985 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 149,339,1985
RTECS®- OSHA PEL (Construc): 29,1926 1994 [shown for informational purposes only]RTECS®- OSHA PEL (Construc): 29,1926.55,1994
RTECS®- OSHA PEL (Fed Cont): 41,50-204 1994 [shown for informational purposes only]RTECS®- OSHA PEL (Fed Cont): 41,50-204.50,1994
RTECS®- OSHA PEL (Gen Indu): 29,1910 1994 [shown for informational purposes only]RTECS®- OSHA PEL (Gen Indu): 29,1910.1000,1994
RTECS®- OSHA PEL (Shipyard): 29,1915 1993 [shown for informational purposes only]RTECS®- OSHA PEL (Shipyard): 29,1915.1000,1993

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