Donate to EWG Today!
DISODIUM EDTA
Score
Data: Fair
CAS139-33-3
moisturizer (469 products)
facial moisturizer/ treatment (426 products)
anti-aging (380 products)
conditioner (365 products)
facial cleanser (286 products)
Show all 3,804 products that contain DISODIUM EDTA.
how to read the score

Get The Guide!


Want a free Cosmetics Guide? Donate $5 to EWG today!

DISODIUM EDTA


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicityyes
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other HIGH concerns: Enhanced skin absorption
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Chelating Agent; VISCOSITY CONTROLLING

About DISODIUM EDTA: EDTA (ethylenediaminetetraacetic acid) is a chelating agent, used to sequester and decrease the reactivity of metal ions that may be present in a product.

Synonym(s): ACETIC ACID, (ETHYLENEDINITRILO) TETRA-, DISODIUM SALT; DISODIUM EDETATE; DISODIUM N,N'-1,2-ETHANEDIYLBIS [N- (CARBOXYMETHYL) GLYCINE] ; DISODIUM ETHYLENEDIAMINETETRAACETATE; EDETATE DISODIUM; DISODIUM SALT ACETIC ACID, (ETHYLENEDINITRILO) TETRA-; (ETHYLENEDINITRILO) TETRA- DISODIUM SALT ACETIC ACID; N,N'-1,2-ETHANEDIYLBIS [N- (CARBOXYMETHYL ) - DISODIUM SALT GLYCINE; DISODIUM DIHYDROGEN ETHYLENEDIAMINETETRAACETATE; GLYCINE, N,N 1,2ETHANEDIYLBIS [N (CARBOXYMETHYL) , DISODIUMSALT; N,N'-1,2-ETHANEDIYLBIS [N- (CARBOXYMETHYL) GLYCINE] DISODIUM SALT

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
23,691 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Enhanced skin absorption

type of concern product conditions reference
Penetration enhancer    Cosmetic Ingredient Review Assessments

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Food Additive Status
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List
show more

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusDISODIUM EDTA• MISC
• REG/FS
• 100 ppm - Promote color retention in frozen white potatoes
• incl cut potatoes - CFR172.135
• 110 ppm - Canned potatoes 155.200
• 165 ppm - For color retention in cnd cooked legumes (all cooked
• canned other than black-eyed peas) or kidney beans
•
Cosmetic Ingredient Review AssessmentsDISODIUM EDTAQQQ01,QQQ11; D+, R+, M-, PE
FDA Everything Added to FoodEDTA, DISODIUM• ASP
Environment Canada Domestic Substance ListGLYCINE, N,N'-1,2-ETHANEDIYLBIS[N-(CARBOXYMETHYL)-, DISODIUM SALT,,,,,,,,,
RTECS®- Science 1971DISODIUM EDTA• reproductive - Central nervous system (rat TDLo)
• developmental - Craniofacial (rat TDLo)
• reproductive - Female fertility index (rat TDLo)
• developmental - Fetal death (rat TDLo)
• reproductive - Litter size (rat TDLo)
• reproductive - Musculoskeletal system (rat TDLo)

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Biochemical Pharmacology 1973DISODIUM EDTA• reproductive - Post-implantation mortality (rat TDLo)
RTECS®- CIS, Chromosome Information Service 1974DISODIUM EDTA• mutagenic - Positive mutation assay: Cytogenetic Analysis (grasshopper par)
RTECS®- CIS, Chromosome Information Service 1974DISODIUM EDTA• mutagenic - Positive mutation assay: Cytogenetic Analysis (grasshopper par)
RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology 1968DISODIUM EDTA• metabolic - Weight loss or decreased weight gain (rat TDLo)
• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Food and Chemical Toxicology 1991DISODIUM EDTA• mutagenic - Positive mutation assay: Micronucleus test (mouse orl)
RTECS®- Food and Chemical Toxicology 1991DISODIUM EDTA• mutagenic - Positive mutation assay: Micronucleus test (mouse orl)
RTECS®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002DISODIUM EDTA• brain, nervous system, or behavioral effect - Ataxia (rat LD50)
• broad systemic - Broad systemic toxicity (mouse LD50)
• brain, nervous system, or behavioral effect - Convulsions or effect on seizure threshold (rat LD50)
• gastrointestinal - Hypermotility, diarrhea (rat LD50)
RTECS®- Nippon Yakurigaku Zasshi 1956DISODIUM EDTA• broad systemic - Broad systemic toxicity (rabbit LD50)
• brain, nervous system, or behavioral effect - Convulsions or effect on seizure threshold (rabbit LD50)
• kidney or renal system - Other changes (rabbit TDLo)
RTECS®- Nippon Yakurigaku Zasshi 1956DISODIUM EDTA• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- U 3781DISODIUM EDTA• broad systemic - Broad systemic toxicity (mouse LD50)

references
government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
RTECS®- Science 1971RTECS®- Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- 173,62,1971
RTECS®- Biochemical Pharmacology 1973 [shown for informational purposes only]RTECS®- Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- 22,407,1973
RTECS®- CIS, Chromosome Information Service 1974 [shown for informational purposes only]RTECS®- CIS, Chromosome Information Service. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) No.1- 16,18,1974
RTECS®- CIS, Chromosome Information Service 1974 [shown for informational purposes only]RTECS®- CIS, Chromosome Information Service. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) No.1- 1961- 16,18,1974
RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology 1968 [shown for informational purposes only]RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. 27,465,1968
RTECS®- Food and Chemical Toxicology 1991 [shown for informational purposes only]RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 29,845,1991
RTECS®- Food and Chemical Toxicology 1991 [shown for informational purposes only]RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 29,845,1991
RTECS®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002 [shown for informational purposes only]RTECS®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V.16- 1997- 21,95,2002
RTECS®- Nippon Yakurigaku Zasshi 1956 [shown for informational purposes only]RTECS®- Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- -1944 52,113,1956
RTECS®- Nippon Yakurigaku Zasshi 1956 [shown for informational purposes only]RTECS®- Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- -1944 52,126S,1956
RTECS®- U 3781 [shown for informational purposes only]RTECS®- U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#03781

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.