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Fair

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DIETHYL PHTHALATE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
 
 
Use restrictions
 
 
Other LOW concerns: Data gaps, Ecotoxicology, Endocrine disruption, Organ system toxicity (non-reproductive)

About DIETHYL PHTHALATE: Diethyl Phthalate is an aromatic diester of ethyl alcohol and phthalic acid.

Function(s): Denaturant; Fragrance Ingredient; Plasticizer; Solvent; FILM FORMING; HAIR CONDITIONING; MASKING; PLASTICISER

Synonym(s): 1,2-BENZENEDICARBOXYLIC ACID, DIETHYL ESTER; 1,2BENZENEDICARBOXYLIC ACID, DIETHYL ESTER; DEP; DIETHYL 1,2-BENZENEDICARBOXYLATE; DIETHYL ESTER 1,2-BENZENEDICARBOXYLIC ACID; DIETHYLPHTHALATE; 1,2-BENZENEDICARBOXYLIC ACID, DIETHYL ESTER; ANOZOL; DEP; DIETHYL 1,2-BENZENEDICARBOXYLATE; DIETHYL O-PHTHALATE

Developmental/reproductive toxicity

Concern Reference
Limited evidence of reproductive toxicityNational Library of Medicine HazMap

Endocrine disruption

Concern Reference
Limited evidence of disruptionSwan SH
Associated with endocrine disruptionParveen M, Inoue A, Ise R, Tanji M, Kiyama R
Associated with endocrine disruptionHong EJ, Ji YK, Choi KC, Manabe N, Jeung EB
Associated with endocrine disruptionHarris CA, Henttu P, Parker MG, Sumpter JP

Allergies/immunotoxicity

Concern Reference
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Organ system toxicity (non-reproductive)

Concern Reference
One or more animal studies show effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Categorized List of Inert Pesticide Ingredients
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Ecotoxicology

Concern Reference
Wildlife and environmental toxicityEPA Clean Water Act - Priority Pollutants
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
Safety assessment was based on related chemicalCosmetic Ingredient Review Assessments
2,983 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Persistence and bioaccumulation

Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
Harris CA, Henttu P, Parker MG, Sumpter JP. 1997. The Estrogenic Activity of Phthalate Esters In Vitro. Environmental Health Perspectives 105(8): 802-811.
Hong EJ, Ji YK, Choi KC, Manabe N, Jeung EB. 2005. Conflict of estrogenic activity by various phthalates between in vitro and in vivo models related to the expression of Calbindin-D9k. J Reprod Dev. 51(2): 253-63.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Parveen M, Inoue A, Ise R, Tanji M, Kiyama R. 2008. Evaluation of estrogenic activity of phthalate esters by gene expression profiling using a focused microarray (EstrArray). Environ Toxicol Chem. 27(6): 1416-25.
Swan SH. 2008. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res 108(2): 177-84.

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