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Data: Robust

Dibutyl Phthalate

IMAGE SOURCE: PubChem

SEARCH PRODUCTS

Other Concerns

Use restrictions (high), Endocrine disruption (moderate), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (high), and Ecotoxicology (low)

SYNONYMS

● 1,2-BENZENEDICARBOXYLIC ACID, DIBUTYL ESTER
● BUTYL PHTHALATE
● DBP
● DI-N-BUTYLPHTHALATE
● DIBUTYL 1,2-BENZENEDICARBOXYLATE
● DIBUTYL ESTER 1,2-BENZENEDICARBOXYLIC ACID
● DIBUTYL PHTHALATE
● DIBUTYL PHTHALATE; DIBUTYL PHTHALATE
● DIBUTYL PHTHALATES

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient


The State of California and other authoritative bodies have classified dibutyl phthalate (DBP) as a reproductive and developmental toxicant, and the European Union banned the use of this ingredient in cosmetics and personal care products. In animal studies, exposure to DBP during gestation causes infertility, cryptorchidism and problems in sperm development, adverse effects similar to human testicular dysgenesis syndrome. Prenatal exposure to DBP has been associated with anatomical changes in the reproductive system development in baby boys. In adult men, DBP has been correlated with changes in serum hormone levels, lower sperm concentration and motility, and decreased fertility.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • MODERATE
    Developmental and Reproductive Toxicity
  • HIGH
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

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Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Known human respiratory toxicantEPA Hazardous Air Pollutants
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs
One or more animal studies show any effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Categorized List of Inert Pesticide Ingredients
Classified as a low human health priorityEnvironment Canada Domestic Substance List
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Use restrictions

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CONCERN REFERENCE
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCosIng

Endocrine disruption

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CONCERN REFERENCE
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
Limited evidence of endocrine disruptionScorecard.org Toxicity Information
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyOur Stolen Future Endocrine Disruptors
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyIllinois EPA Chemicals Associated with Endocrine System

Developmental/reproductive toxicity

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CONCERN REFERENCE
Possible human developmental toxicantCalifornia EPA Proposition 65
Limited evidence of reproductive toxicityNational Library of Medicine HazMap
Limited evidence of reproductive toxicityCPS&Q - Classification & Labelling
Limited evidence of developmental toxicityScorecard.org Toxicity Information

Persistence and bioaccumulation

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CONCERN REFERENCE
Persistent, bioaccumulative in wildlifeOSPAR PBTs - Substances of Possible Concern
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Allergies/immunotoxicity

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CONCERN REFERENCE
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Ecotoxicology

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CONCERN REFERENCE
Wildlife and environmental toxicityEPA Clean Water Act - Priority Pollutants
Wildlife and environmental toxicityCPS&Q - Classification & Labelling
Wildlife and environmental toxicityIllinois EPA Chemicals Associated with Endocrine System
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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CONCERN REFERENCE
Insufficient data to determine safetyEPA Integrated Risk Information System (IRIS)
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
13018 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Cancer

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CONCERN REFERENCE
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsEPA Integrated Risk Information System (IRIS)
  • EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
  • EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
  • EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
  • ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
  • Colborn T, D Dumanoski, JP Myers. 2006. Widespread Pollutants with Endocrine-disrupting Effects. Updated from original listing in "Our Stolen Future" (1996).
  • Illinois EPA (Illinois Environmental Protection Agency). 2000. Preliminary list of chemicals associated with endocrine system effects in animals and humans (*) or in vitro (+). In EPA (U.S. Environmental Protection Agency) 2000. Handbook for Non-Cancer Health Effects Valuation, Appendix C.
  • California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • OSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
  • EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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