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DIAZOLIDINYL UREA
Score
Data: Limited
CAS78491-02-8
facial moisturizer/ treatment (180 products)
anti-aging (166 products)
moisturizer (160 products)
styling gel/ lotion (137 products)
facial cleanser (103 products)
Show all 1,573 products that contain DIAZOLIDINYL UREA.
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DIAZOLIDINYL UREA


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicityyes
Use restrictionsyes
Contamination concerns: FORMALDEHYDE

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Preservative

About DIAZOLIDINYL UREA: Diazolidinyl urea is an antimicrobial preservative that acts as a formaldehyde releaser in cosmetics and personal care products.

Synonym(s): N- [1,3-BIS (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL] -N,N'-BIS (HYDROXYMETHYL) UREA; UREA, N- [1,3-BIS (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL-N,N'-BIS (HYDROXYMETHYL) -; N- [1,3-BIS (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL-N,N'-BIS (HYDROXYMETHYL) - UREA; DIAZOLIDYNL UREA; 1- [1,3-BIS (HYDROXYMETHYL) -2,5-DIOXOIMIDAZOLIDIN-4-YL] -1,3-BIS (HYDROXYMETHYL) UREA; UREA, N [1,3BIS (HYDROXYMETHYL) 2,5DIOXO4IMIDAZOLIDINYL] N,N BIS (HYDROXYMETHYL) ; GERMALL 11; IMIDAZOLIDINYL UREA 11; N- (1,3-BIS (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL) -N,N'-BIS (HYDROXYMETHYL) UREA

This ingredient may be derived from animals. From PETA's Caring Consumer: Excreted from urine and other bodily fluids. In deodorants, ammoniated dentifrices, mouthwashes, hair colorings, hand creams, lotions, shampoos, etc. Used to "brown" baked goods, such as pretzels. Der ... read more

Allergies/immunotoxicity

type of concern product conditions reference
Known human immune system toxicant    National Library of Medicine HazMap
Human skin toxicant - strong evidence    Cosmetic Ingredient Review Assessments
Human skin toxicant - strong evidence   

Use restrictions

type of concern product conditions reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications   Cosmetic Ingredient Review Assessments

Data gaps

type of concern product conditions reference
49 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List
show more

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
Cosmetic Ingredient Review AssessmentsDIAZOLIDINYL UREAQQQ02,QQQ36; I, S, M-
National Library of Medicine HazMapDIAZOLIDINYL UREASS: Yes;
Environment Canada Domestic Substance ListUREA, N-[1,3-BIS(HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL]-N,N'-BIS(HYDROXYMETHYL )-,,,,,,,,,

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Journal of the American College of Toxicology 1990DIAZOLIDINYL UREA• metabolic - Weight loss or decreased weight gain (rat TDLo)
• broad systemic - Broad systemic toxicity (rat LD50)
• endocrine system - Changes in adrenal weight (rat TDLo)
• brain, nervous system, or behavioral effect - Food intake (animal) (rat TDLo)
• gastrointestinal - Gastritis (rat TDLo)
RTECS®- Journal of Toxicology, Cutaneous and Ocular Toxicology 1995DIAZOLIDINYL UREA• gastrointestinal - Changes in structure or function of salivary glands (mouse LD50)
• brain, nervous system, or behavioral effect - Altered sleep time (including change in righting reflex) (mouse LD50)
• brain, nervous system, or behavioral effect - Ataxia (mouse LD50)
RTECS®- Mutation Research 2002DIAZOLIDINYL UREA• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
• mutagenic - Positive mutation assay: Micronucleus test (hamster fbr)
RTECS®- Mutation Research 2002DIAZOLIDINYL UREA• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
• mutagenic - Positive mutation assay: Micronucleus test (hamster fbr)

references
government/industry list/academic study reference
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
RTECS®- Journal of the American College of Toxicology 1990 [shown for informational purposes only]RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 9(2),229,1990
RTECS®- Journal of Toxicology, Cutaneous and Ocular Toxicology 1995 [shown for informational purposes only]RTECS®- Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- 14,3,1995
RTECS®- Mutation Research 2002 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 514,133,2002
RTECS®- Mutation Research 2002 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 514,133,2002

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