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DEA-C8-18 PERFLUOROALKYLETHYL PHOSPHATE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
 
 

About DEA-C8-18 PERFLUOROALKYLETHYL PHOSPHATE: DEA-C8-18 Perfluoroalkylethyl Phosphate is a diethanolamine salt of a complex mixture ofesters of phosphoric acid and a perfluoroalkylethyl alcohol containing 8 to 18 carbons in the alkyl chain.

Function(s): Surfactant - Emulsifying Agent

Synonym(s): 2,2'-IMINOBIS COMPD. WITHA, ETHANOL; 2,2'-IMINOBIS- COMPD. WITHA -FLUORO-W - [2-PHOSPHPONOOXY) ETHYL] POLY (DIFLUOROMETHYLENE) (2:1) ETHANOL; A'- [PHOSPHINICOBIS (OXY-2,1-ETHANEDIYL) ] BIS [W -FLUOROPOLY (DIFLUOROMETHYLENE) ] (1:1) ; COMPD. WITHA -FLUORO-W - [2-PHOSPHPONOOXY) ETHYL] POLY (DIFLUOROMETHYLENE) (2:1) ETHANOL, 2,2'-IMINOBIS-; COMPD. WITHA, ETHANOL, 2,2'-IMINOBIS; ETHANOL, 2,2 IMINOBIS, COMPD. WITH αFLUOROω [2 (PHOSPHONOOXY) ETHYL] POLY (DIFLUOROMETHYLENE) (2:1) ; ETHANOL, 2,2'-IMINOBIS, COMPD. WITHA,; ETHANOL, 2,2'-IMINOBIS-, COMPD. WITH .ALPHA.-FLUORO-.OMEGA.- [2- (PHOSPHONOOXY) ETHYL] POLY (DIFLUOROMETHYLENE) (2:1) ; ETHANOL, 2,2'-IMINOBIS-, COMPD. WITHA -FLUORO-W - [2-PHOSPHPONOOXY) ETHYL] POLY (DIFLUOROMETHYLENE) (2:1)

Use restrictions

Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCosIng
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Allergies/immunotoxicity

Concern Reference
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Organ system toxicity (non-reproductive)

Concern Reference
Known human respiratory toxicantEPA Hazardous Air Pollutants
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Limited evidence of respiratory toxicityUS EPA, Air Risk Information Support Center
Limited evidence of sense organ toxicityUS EPA, Air Risk Information Support Center
Limited evidence of cardiovascular or blood toxicityCalifornia EPA, Office of Environmental Health Hazard Assessment
One or more animal studies show effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Categorized List of Inert Pesticide Ingredients
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs

Persistence and bioaccumulation

Concern Reference
Persistent, bioaccumulative in wildlife and humans
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Cancer

Concern Reference
Cancer - limited evidenceNational Toxicology Program
Cancer - not classifiable/not likely to be human carcinogenInt'l Agency for Research on Cancer (IARC) - Carcinogens

Developmental/reproductive toxicity

Concern Reference
One or more animal studies show neurodevelopmental effects at moderate dosesCraciunescu CN, Wu R, Zeisel SH

Irritation (skin, eyes, or lungs)

Concern Reference
Limited evidence of skin irritationNational Library of Medicine HazMap

Ecotoxicology

Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Contamination concerns

Impurity Score
PERFLUOROOCTANOIC ACID
Data: Fair

Data gaps

Concern Reference

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document 'Determination of Noncancer Chronic Reference Exposure Levels'. Includes all Chronic Reference Exposure Levels (CRELs) adopted by OEHHA as of August 2003 (http://www.oehha.ca.gov/air/chronic_rels/AllChrels.html, plus draft CRELS proposed through March 2004 (http://www.oehha.ca.gov/air/chronic_rels/index.html., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
Craciunescu CN, Wu R, Zeisel SH. "Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus." FASEB J. 2006 Aug;20(10):1635-40.
Deon JC, Mabury SA. 2007. Production of perfluorinated carboxylic acids (PFCAs) from the biotransformation of polyfluoroalkyl phosphate surfactants (PAPS): exploring routes of human contamination. Environ Sci Technol 41(13): 4799-805.
Deon JC, Mabury SA. 2007. Production of perfluorinated carboxylic acids (PFCAs) from the biotransformation of polyfluoroalkyl phosphate surfactants (PAPS): exploring routes of human contamination. Environ Sci Technol 41(13): 4799-805.; Begley TH, White K, Honigfort P, Twaroski ML, Neches R, Walker RA. 2005. Perfluorochemicals: potential sources of and migration from food packaging. Food Addit Contam 22(10): 1023-31.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
National Toxicology Program. Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2001-2002 for Possible Listing in the Report on Carcinogens, Eleventh Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC.http://ntp-server.niehs.nih.gov/NewHomeRoc/11thConsideration.html National Toxicology Program. Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2004-2005 for Possible Listing in the Report on Carcinogens, Twelfth Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC. http://ntp-server.niehs.nih.gov/NewHomeRoc/12thConsideration.html
OECD, 2006
US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html
US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer