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Data: Limited

D&C Orange No. 5 (Ci 45370)

  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.

IMAGE SOURCE: PubChem

SEARCH PRODUCTS

Other Concerns

Use restrictions (high), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)

SYNONYMS

● 4',5'-DIBROMO-3',6'-DIHYDROXY SPIRO[ISOBENZOFURAN-1(3H), 9'-[9H]XANTHEN]-3-ONE
● 4',5'-DIBROMO-3',6'-DIHYDROXY- DISODIUM SALT SPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE
● 4',5'-DIBROMO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHENE]-3-ONE
● 4',5'-DIBROMO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE, DISODIUM SALT
● 4',5'-DIBROMOFLUORANDIOL, DISODIUM SALT
● 4'5'-DIBROMO- FLUORESCEIN
● 4,5-DIBROMOFLUORESCEIN
● 9'-[9H]XANTHEN]-3-ONE 4',5'-DIBROMO-3',6'-DIHYDROXY SPIRO[ISOBENZOFURAN-1(3H)
● ACID ORANGE 11
● CI 45370
● D&C ORANGE 5
● D&C ORANGE NO. 5
● D&C ORANGE NO. 5 (CI 45370)
● DAIDAI201
● DISODIUM 2-(4,5-DIBROMO-6-OXIDO-3-OXOXANTHEN-9-YL)BENZOATE
● DISODIUM SALT 4',5'-DIBROMO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE
● DISODIUM SALT 4',5'-DIBROMOFLUORANDIOL
● DISODIUM SALT SPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE, 4',5'-DIBROMO-3',6'-DIHYDROXY-
● EOSINIC ACID
● FD&C ORANGE 5
● FLUORESCEIN, 4'5'-DIBROMO-
● ORANGE 201
● ORANGE 5
● ORANGE NO. 201
● SPIRO[ISOBENZOFURAN-1(3H), 9'-[9H]XANTHEN]-3-ONE, 4',5'-DIBROMO-3',6'-DIHYDROXY
● SPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE, 4',5'-DIBROMO-3',6'-DIHYDROXY-
● SPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE, 4',5'-DIBROMO-3',6'-DIHYDROXY-, DISODIUM SALT

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient


D&C Orange 5 is a synthetic dye produced from petroleum or coal tar sources; this dye is FDA-approved for use in pharmaceuticals and cosmetics.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • HIGH
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

Expand content Collapse content
lipstick68 products
nail polish45 products
lip liner7 products
eye shadow5 products
lip gloss4 products
blush3 products
lip balm2 products
foundation2 products
fragrance for women1 products
fragrance for men1 products
serums & essences1 products
hair treatment/serum1 products
body spray1 products
mascara1 products

Use restrictions

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CONCERN REFERENCE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status
Determined safe for use in cosmetics, subject to concentration or use limitations - Color additive approved by FDA for limited uses in cosmeticsFDA Color Additive Status

Persistence and bioaccumulation

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CONCERN REFERENCE
Persistent or bioaccumulative and moderate to high toxicity concern in humansOpen scientific literature
Not suspected to be persistentEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

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CONCERN REFERENCE
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Endocrine disruption

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CONCERN REFERENCE
Associated with endocrine disruptionOpen scientific literature

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Data gaps

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CONCERN REFERENCE
17 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • Open scientific/peer reviewed literature
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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