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CYCLOPENTASILOXANE
Score
Data: Limited
CAS541-02-6
foundation (354 products)
facial moisturizer/ treatment (280 products)
anti-aging (264 products)
conditioner (252 products)
antiperspirant/ deodorant (238 products)
Show all 2,864 products that contain CYCLOPENTASILOXANE.
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CYCLOPENTASILOXANE


image source: PubChem
Health concerns of ingredient
About the ratings
Canceryes
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other MODERATE concerns: Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
Other LOW concerns: Neurotoxicity, Endocrine disruption, Ecotoxicology

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Hair Conditioning Agent; Skin-Conditioning Agent - Emollient; Solvent; SKIN CONDITIONING

About CYCLOPENTASILOXANE: Cyclopentasiloxane (cyclomethicone) is a silicon-based cyclic compound; may be associated with environmental toxicity.

Synonym(s): CYCLOPENTASILOXANE, DECAMETHYL-; DECAMETHYLCYCLOPENTASILOXANE; DECAMETHYL- CYCLOPENTASILOXANE

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as expected to be toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Persistent, bioaccumulative in wildlife    Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Endocrine disruption

type of concern product conditions reference
One or more animal studies show endocrine disruption at moderate doses    McKim JM Jr, Choudhuri S, Wilga PC, Madan A, Burns-Naas LA, Gallavan RH, Mast RW, Naas DJ, Parkinson A, Meeks RG, 1999
show more

Neurotoxicity

type of concern product conditions reference
One or more animal studies show effects at moderate doses    Jean PA, McCracken KA, Arthurton JA, Plotzke KP, 2005

Cancer

type of concern product conditions reference
One or more animal studies show tumor formation at moderate doses    Dow Corning Corporation, 2005

Ecotoxicology

type of concern product conditions reference
Suspected to be an environmental toxin and be persistent or bioaccumulative    Environment Canada Domestic Substance List
show more

Data gaps

type of concern product conditions reference
48 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)CYCLOPENTASILOXANE, DECAMETHYLIdentified as a priority action PBT under Environment Canada's July 2006 assessment
Dow Corning Corporation, 2005DECAMETHYLCYCLOPENTASILOXANEUterine tumors in female rats
Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG, 2007DECAMETHYLCYCLOPENTASILOXANEIncreased anogenital distance observed in rats at a moderate dose.
McKim JM Jr, Choudhuri S, Wilga PC, Madan A, Burns-Naas LA, Gallavan RH, Mast RW, Naas DJ, Parkinson A, Meeks RG, 1999DECAMETHYLCYCLOPENTASILOXANEAlters activity of liver enzyemes that metabolize chemicals with hormone activity.
Jean PA, McCracken KA, Arthurton JA, Plotzke KP, 2005DECAMETHYLCYCLOPENTASILOXANEModerate dose in rate suggested dopamine D2-receptor behavior on pituitary cells.
Environment Canada Domestic Substance ListCYCLOPENTASILOXANE, DECAMETHYL-Y-Categorization,,,Y-Persistent,Y-Bioaccumulative,Y-AquaticTox,,,,
IFRA Fragrance Ingredient ListDECAMETHYLCYCLOPENTASILOXANEreported as used in fragrance compounds in 2008

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986CYCLOPENTASILOXANE• sense organ - Primary eye irritant (rabbit )
• skin - Primary skin irritant (rabbit )
RTECS®- National Technical Information Service 0101CYCLOPENTASILOXANE• liver - Changes in liver weight (rat TDLo)
• biochemical - Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) (rat TDLo)
• liver - Other changes (rat TDLo)

references
government/industry list/academic study reference
Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
Open scientific literatureDow Corning Corporation. 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.
Open scientific literatureSiddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG. 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.
Open scientific literatureMcKim JM Jr, Choudhuri S, Wilga PC, Madan A, Burns-Naas LA, Gallavan RH, Mast RW, Naas DJ, Parkinson A, Meeks RG. 1999. Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopenta- siloxane. Toxicol Sci. 50(1):10-19.
Open scientific literatureJean PA, McCracken KA, Arthurton JA, Plotzke KP. 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 [shown for informational purposes only]RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,1234,1986
RTECS®- National Technical Information Service 0101 [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0590101

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.