| Score |  Data: Fair |
| CAS | 91-64-5 |
| moisturizer (67 products) | |
| fragrance for women (65 products) | |
| hair color and bleaching (51 products) | |
| facial moisturizer/ treatment (47 products) | |
| fragrance for men (41 products) | |
| Show all 527 products that contain COUMARIN. | |
| how to read the score | |
 image source: PubChem |
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Function/use(s): Fragrance Ingredient; MASKING
About COUMARIN: Coumarin is a naturally occurring and synthetically produced scent chemical; associated with allergies and contact dermatitis.
Synonym(s): 2H-1-BENZOPYRAN-2-ONE; TONKA BEAN CAMPHOR; 2H1BENZOPYRAN2ONE; 1,2-BENZOPYRONE; 2-OXO-1,2-BENZOPYRAN; 2H-1-BENZOPYRAN, 2-OXO-; 2H-1-BENZOPYRAN-2-ONE; BENZO-ALPHA-PYRONE; CIS-O-COUMARINIC ACID LACTONE; COUMARINIC ANHYDRIDE; CUMARIN
Allergies/immunotoxicity | ||
|---|---|---|
| type of concern | product conditions | reference |
| Known human immune system toxicant | EU Banned and Restricted Fragrances | |
Use restrictions | ||
|---|---|---|
| type of concern | product conditions | reference |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn) | International Fragrance Association Codes & Standards | |
Cancer | ||
|---|---|---|
| type of concern | product conditions | reference |
| Cancer - limited evidence | Carcinogenic Potency Database, 1298 | |
| show more | ||
Miscellaneous | ||
|---|---|---|
| type of concern | product conditions | reference |
| Prohibited for use in food | FDA Food Additive Status | |
Data gaps | ||
|---|---|---|
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 7,095 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed | |
Organ system toxicity (non-reproductive) | ||
|---|---|---|
| type of concern | product conditions | reference |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List | |
Persistence and bioaccumulation | ||
|---|---|---|
| type of concern | product conditions | reference |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List | |
| show more | ||
Ecotoxicology | ||
|---|---|---|
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List | |
Government, industry, academic studies and classifications |
||
|---|---|---|
| government/industry list/academic study | appears on list as | classification(s) |
| FDA Food Additive Status | COUMARIN | • SY/FS • BAN • Any food containing coumarin added as such or as a constituent of tonka beans or tonka extract is adulterated. |
| FDA Everything Added to Food | COUMARIN--PROHIBITED | • BAN |
| EU Banned and Restricted Fragrances | COUMARIN | Fragrance chemical, which, according to existing knowledge, is frequently reported as a well-recognised consumer allergen |
| Int'l Agency for Research on Cancer (IARC) - Carcinogens | COUMARIN | IARC GROUP 3 |
| Carcinogenic Potency Database, 1298 | COUMARIN | Cancer Hazards: suspected |
| Environment Canada Domestic Substance List | 2H-1-BENZOPYRAN-2-ONE | ,,,,,,,,, |
| Association of Occupational and Environmental Clinics | COUMARIN | • o |
| IFRA Fragrance Ingredient List | COUMARIN | reported as used in fragrance compounds in 2008 |
| International Fragrance Association Codes & Standards | #3 43A COUMARIN | Restricted |
| International Fragrance Association Codes & Standards | COUMARIN | Restricted |
Other RTECS® classifications [shown for informational purposes only] |
||
|---|---|---|
| government/industry list/academic study | appears on list as | classification(s) |
| RTECS®- Arzneimittel-Forschung 1965 | COUMARIN | • biochemical - True cholinesterase (mouse LD50) • brain, nervous system, or behavioral effect - Analgesia (mouse LD50) |
| RTECS®- Arzneimittel-Forschung 1967 | COUMARIN | • reproductive - Fetotoxicity (mouse TDLo) |
| RTECS®- Biochemical Pharmacology 2004 | COUMARIN | • biochemical - Effect on inflammation or mediation of inflammation (rat TDLo) • liver - Other changes (rat TDLo) |
| RTECS®- Environmental and Molecular Mutagenesis 1987 | COUMARIN | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster ovr) • mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster ovr) |
| RTECS®- Environmental and Molecular Mutagenesis 2001 | COUMARIN | • mutagenic - Positive mutation assay: Morphological Transform (mouse fbr) |
| RTECS®- Environmental and Molecular Mutagenesis 1987 | COUMARIN | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster ovr) • mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster ovr) |
| RTECS®- Environmental and Molecular Mutagenesis 2001 | COUMARIN | • mutagenic - Positive mutation assay: Morphological Transform (mouse fbr) |
| RTECS®- Environmental Mutagenesis 1983 | COUMARIN | • mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) |
| RTECS®- Food and Chemical Toxicology 2001 | COUMARIN | • brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (mouse LD) |
| RTECS®- Food and Chemical Toxicology 2002 | COUMARIN | • metabolic - Weight loss or decreased weight gain (hamster TDLo) • liver - Changes in liver weight (rat TDLo) • biochemical - Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) (rat TDLo) • liver - Other changes (hamster TDLo) • biochemical - Other transferases (hamster TDLo) |
| RTECS®- Food and Chemical Toxicology 2001 | COUMARIN | • brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (mouse TDLo) |
| RTECS®- Food and Cosmetics Toxicology 1974 | COUMARIN | • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- Food and Cosmetics Toxicology 1964 | COUMARIN | • liver - Other changes (guinea pig LD50) • brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (guinea pig LD50) |
| RTECS®- Food and Cosmetics Toxicology 1965 | COUMARIN | • liver - Changes in liver weight (rat TDLo) • biochemical - Dehydrogenases (rat TDLo) • biochemical - Phosphatases (rat TDLo) |
| RTECS®- Fundamental and Applied Toxicology 1996 | COUMARIN | • metabolic - Weight loss or decreased weight gain (hamster TDLo) • liver - Changes in liver weight (hamster TDLo) |
| RTECS®- Human & Experimental Toxicology 1990 | COUMARIN | • metabolic - Weight loss or decreased weight gain (rat TDLo) • liver - Other changes (rat TDLo) • biochemical - Other transferases (rat TDLo) |
| RTECS®- Human Toxicology 1989 | COUMARIN | • liver - Liver function tests impaired (woman TDLo) |
| RTECS®- Mutation Research 1999 | COUMARIN | • mutagenic - Positive mutation assay: other mutation test systems (Escherichia coli ) |
| RTECS®- Mutation Research 2005 | COUMARIN | • mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) |
| RTECS®- Mutation Research 1999 | COUMARIN | • mutagenic - Positive mutation assay: other mutation test systems (Escherichia coli ) |
| RTECS®- Mutation Research 2005 | COUMARIN | • mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) |
| RTECS®- National Technical Information Service 5582 | COUMARIN | • liver - Hepatitis (hepatocellular necrosis), diffuse (rat TDLo) • blood - Changes in platelet count (rat TDLo) • liver - Liver function tests impaired (rat TDLo) |
| RTECS®- National Technical Information Service 5761 | COUMARIN | • liver - Hepatitis (hepatocellular necrosis), diffuse (rat TDLo) • mutagenic - gastrointestinal neoplasms (mouse TDLo) • mutagenic - kidney or renal system neoplasms (rat TDLo) • cancer - respiratory neoplasms (mouse TDLo) • cancer - respiratory tumors (mouse TDLo) |
| RTECS®- National Toxicology Program Technical Report Series 1993 | COUMARIN | • blood - Changes in erythrocyte (RBC) count (rat TDLo) • liver - Changes in liver weight (mouse TDLo) • liver - Hepatitis (hepatocellular necrosis), zonal (rat TDLo) • cancer - kidney or renal system neoplasms (rat TDLo) • blood - Normocytic anemia (mouse TDLo) • cancer - respiratory tumors (mouse TDLo) • biochemical - Transaminases (rat TDLo) |
| RTECS®- Proceedings of the National Academy of Sciences of the United States of America 1962 | COUMARIN | • mutagenic - Positive mutation assay: DNA Damage (mammal lym) |
| RTECS®- Proceedings of the National Academy of Sciences of the United States of America 1962 | COUMARIN | • mutagenic - Positive mutation assay: DNA Damage (mammal lym) |
| RTECS®- Toxicologist 2001 | COUMARIN | • liver - Hepatitis (hepatocellular necrosis), zonal (mouse TDLo) • respiratory - Other changes (mouse TDLo) • biochemical - Other transferases (mouse TDLo) • respiratory - Structural or functional change in trachea or bronchi (mouse TDLo) |
| RTECS®- Toxicology 1973 | COUMARIN | • cancer - liver tumor formations - equivocal (rat TD) |
| RTECS®- Yakugaku Zasshi 1963 | COUMARIN | • broad systemic - Broad systemic toxicity (mouse LD50) |
references |
||
|---|---|---|
| government/industry list/academic study | reference | |
| FDA Food Additive Status | FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006. | |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. | |
| EU Banned and Restricted Fragrances | SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000. | |
| Int'l Agency for Research on Cancer (IARC) - Carcinogens | IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures). | |
| Scorecard.org Toxicity Information | Carcinogenic Potency Database. http://potency.berkeley.edu/app14.html Environmental Defense reviewed this compilation of results on carcinogenicity in rats and mice covering 1298 chemicals and added any chemical with positive results in at least two species by a relevant route of exposure to its list of suspect carcinogens. | |
| Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. | |
| Association of Occupational and Environmental Clinics | AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation. | |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 | |
| International Fragrance Association Codes & Standards | IFRA (International Fragrance Association). 2006. Codes and Standards. | |
| RTECS®- Arzneimittel-Forschung 1965 [shown for informational purposes only] | RTECS®- Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- 15,897,1965 | |
| RTECS®- Arzneimittel-Forschung 1967 [shown for informational purposes only] | RTECS®- Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- 17,97,1967 | |
| RTECS®- Biochemical Pharmacology 2004 [shown for informational purposes only] | RTECS®- Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- 67,2141,2004 | |
| RTECS®- Environmental and Molecular Mutagenesis 1987 [shown for informational purposes only] | RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- 10(Suppl 10),1,1987 | |
| RTECS®- Environmental and Molecular Mutagenesis 2001 [shown for informational purposes only] | RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- 37,231,2001 | |
| RTECS®- Environmental and Molecular Mutagenesis 1987 [shown for informational purposes only] | RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 10(Suppl 10),1,1987 | |
| RTECS®- Environmental and Molecular Mutagenesis 2001 [shown for informational purposes only] | RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 37,231,2001 | |
| RTECS®- Environmental Mutagenesis 1983 [shown for informational purposes only] | RTECS®- Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. 5(Suppl 1),3,1983 | |
| RTECS®- Food and Chemical Toxicology 2001 [shown for informational purposes only] | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 39,837,2001 | |
| RTECS®- Food and Chemical Toxicology 2002 [shown for informational purposes only] | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 40,809,2002 | |
| RTECS®- Food and Chemical Toxicology 2001 [shown for informational purposes only] | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 837,39,2001 | |
| RTECS®- Food and Cosmetics Toxicology 1974 [shown for informational purposes only] | RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 12,385,1974 | |
| RTECS®- Food and Cosmetics Toxicology 1964 [shown for informational purposes only] | RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 2,327,1964 | |
| RTECS®- Food and Cosmetics Toxicology 1965 [shown for informational purposes only] | RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 3,457,1965 | |
| RTECS®- Fundamental and Applied Toxicology 1996 [shown for informational purposes only] | RTECS®- Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 34,105,1996 | |
| RTECS®- Human & Experimental Toxicology 1990 [shown for informational purposes only] | RTECS®- Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- 9,323,1990 | |
| RTECS®- Human Toxicology 1989 [shown for informational purposes only] | RTECS®- Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- -1981 8,501,1989 | |
| RTECS®- Mutation Research 1999 [shown for informational purposes only] | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 445,81,1999 | |
| RTECS®- Mutation Research 2005 [shown for informational purposes only] | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 578,210,2005 | |
| RTECS®- Mutation Research 1999 [shown for informational purposes only] | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 445,81,1999 | |
| RTECS®- Mutation Research 2005 [shown for informational purposes only] | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 578,210,2005 | |
| RTECS®- National Technical Information Service 5582 [shown for informational purposes only] | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0555582 | |
| RTECS®- National Technical Information Service 5761 [shown for informational purposes only] | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB94-215761 | |
| RTECS®- National Toxicology Program Technical Report Series 1993 [shown for informational purposes only] | RTECS®- National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- NTP-TR-422,1993 | |
| RTECS®- Proceedings of the National Academy of Sciences of the United States of America 1962 [shown for informational purposes only] | RTECS®- Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- 48,686,1962 | |
| RTECS®- Proceedings of the National Academy of Sciences of the United States of America 1962 [shown for informational purposes only] | RTECS®- Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 48,686,1962 | |
| RTECS®- Toxicologist 2001 [shown for informational purposes only] | RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 60,210,2001 | |
| RTECS®- Toxicology 1973 [shown for informational purposes only] | RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 1,93,1973 | |
| RTECS®- Yakugaku Zasshi 1963 [shown for informational purposes only] | RTECS®- Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- 83,1124,1963 | |
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