CITRAL || Skin Deep® Cosmetics Database | Environmental Working Group

CITRAL

Score	Data: Fair
CAS	5392-40-5
fragrance for women (117 products)
moisturizer (99 products)
facial moisturizer/ treatment (80 products)
lip gloss (69 products)
fragrance for men (55 products)
Show all 775 products that contain CITRAL.
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CITRAL

image source: PubChem

Health concerns of ingredient
About the ratings
Cancer	no information
Developmental & reproductive toxicity	no information
Allergies & immunotoxicity
Use restrictions
Contamination concerns: none
Other HIGH concerns: Irritation (skin, eyes, or lungs)
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Flavoring Agent; Fragrance Ingredient; MASKING

About CITRAL: Citral is a naturally occurring scent ingredient; manufactured synthetically on a large scale; associated with allergies and contact dermatitis.

Synonym(s): 3,7-DIMETHYL-2,6-OCTADIENAL; 2,6-OCTADIENAL, 3,7-DIMETHYL-; 3,7-DIMETHYL- 2,6-OCTADIENAL; 2,6OCTADIENAL, 3,7DIMETHYL; 3,7-DIMETHYL-2,6-OCTADIENAL; LEMSYN GB; NCI-C56348

Allergies/immunotoxicity
type of concern	product conditions	reference
Known human immune system toxicant		EU Banned and Restricted Fragrances
Limited evidence of immune system toxicity	products for use on skin	European Union - Classification & Labelling

Use restrictions
type of concern	product conditions	reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)		International Fragrance Association Codes & Standards

Irritation (skin, eyes, or lungs)
type of concern	product conditions	reference
Classified as irritant		European Union - Classification & Labelling

Data gaps
type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
517 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Multiple, additive exposure sources
type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Everything Added to Food

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)
type of concern	product conditions	reference
Classified as not expected to be potentially toxic or harmful		Environment Canada Domestic Substance List

Ecotoxicology
type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study	appears on list as	classification(s)
European Union - Classification & Labelling	CITRAL	Xi; R38; R43
FDA Everything Added to Food	CITRAL	• ASP
International Fragrance Association Codes & Standards	CITRAL	Restricted
Environment Canada Domestic Substance List	2,6-OCTADIENAL, 3,7-DIMETHYL-	,,,,,,,,,
EU Banned and Restricted Fragrances	CITRAL	Fragrance chemical, which, according to existing knowledge, is frequently reported as a well-recognised consumer allergen
IFRA Fragrance Ingredient List	CITRAL	reported as used in fragrance compounds in 2008
International Fragrance Association Codes & Standards	CITRAL	Restricted
International Fragrance Association Codes & Standards	CITRAL	Restricted

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study	appears on list as	classification(s)
RTECS^®- "Vrednie chemichescie veshestva 1998	CITRAL	• reproductive - Post-implantation mortality (rat TDLo)
RTECS^®- "Vrednie chemichescie veshestva 1998	CITRAL	• reproductive - Ovaries, fallopian tubes (rat TDLo) • broad systemic - Broad systemic toxicity (mouse LD50) • kidney or renal system - Changes in kidney weight (rat LD50) • liver - Changes in liver weight (rat LD50)
RTECS^®- Biochemical Journal 1940	CITRAL
RTECS^®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology 1996	CITRAL	• tumore formation - Other changes (rat TDLo)
RTECS^®- Cosmetics and Toiletries 1979	CITRAL	• skin - Primary skin irritant (rabbit )
RTECS^®- Cosmetics and Toiletries 1979	CITRAL	• skin - Primary skin irritant (guinea pig )
RTECS^®- FAO Nutrition Meetings Report Series 1967	CITRAL	• kidney or renal system - Interstitial nephritis (rabbit TDLo) • blood - Other changes (rabbit TDLo) • kidney or renal system - Proteinuria (rabbit TDLo)
RTECS^®- Food and Chemical Toxicology 1987	CITRAL	• broad systemic - Broad systemic toxicity (rabbit LD50) • liver - Changes in liver weight (rat TDLo) • biochemical - CoA (rat TDLo) • biochemical - Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) (rat TDLo)
RTECS^®- Food and Chemical Toxicology 1993	CITRAL	• liver - Changes in liver weight (mouse TDLo) • liver - Other changes (mouse TDLo)
RTECS^®- Food and Cosmetics Toxicology 1979	CITRAL	• skin - Primary skin irritant (rabbit )
RTECS^®- Food and Cosmetics Toxicology 1980	CITRAL	• reproductive - Oogenesis (rat TDLo) • reproductive - Post-implantation mortality (rat TDLo) • reproductive - Pre-implantation mortality (rat TDLo) • reproductive - Viability index (rat TDLo)
RTECS^®- Food and Cosmetics Toxicology 1964	CITRAL	• brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (rat LD50)
RTECS^®- Journal of Reproduction and Fertility 1979	CITRAL	• reproductive - Live birth index (rat TDLo) • reproductive - Other measures of fertility (rat TDLo) • reproductive - Ovaries, fallopian tubes (rat TDLo) • reproductive - Viability index (rat TDLo) • broad systemic - Broad systemic toxicity (rat LD50)
RTECS^®- Journal of the Society of Cosmetic Chemists 1977	CITRAL	• skin - Primary skin irritant (guinea pig )
RTECS^®- Journal of the Society of Cosmetic Chemists 1977	CITRAL	• skin - Primary skin irritant (guinea pig )
RTECS^®- Toxicology 2005	CITRAL	• immune system - Increase in cellular immune response (mouse TDLo) • immune system - Increase in humoral immune response (mouse TDLo)
RTECS^®- Toxicology 1995	CITRAL	• reproductive - Female fertility index (rat TDLo) • reproductive - Fetal death (rat TDLo) • reproductive - Fetotoxicity (rat TDLo) • reproductive - Musculoskeletal system (rat TDLo) • reproductive - Other effects (rat TDLo) • reproductive - Pre-implantation mortality (rat TDLo)
RTECS^®- Urological Research 1992	CITRAL	• reproductive - Prostate, seminal vesicle, Cowper's gland, accessory glands (rat TDLo) • skin - Dermatitis, other (rat TDLo) • skin - Hair (rat TDLo)

references
government/industry list/academic study	reference
European Union - Classification & Labelling	CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
FDA Everything Added to Food	FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
International Fragrance Association Codes & Standards	IFRA (International Fragrance Association). 2006. Codes and Standards.
Environment Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU Banned and Restricted Fragrances	SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS^®- "Vrednie chemichescie veshestva 1998 [shown for informational purposes only]	RTECS^®- "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998. -,286,1998
RTECS^®- "Vrednie chemichescie veshestva 1998 [shown for informational purposes only]	RTECS^®- "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998. -,291,1998
RTECS^®- Biochemical Journal 1940 [shown for informational purposes only]	RTECS^®- Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- 34,1196,1940
RTECS^®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology 1996 [shown for informational purposes only]	RTECS^®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.74- 1983- 115,169,1996
RTECS^®- Cosmetics and Toiletries 1979 [shown for informational purposes only]	RTECS^®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- 94(8),41,1979
RTECS^®- Cosmetics and Toiletries 1979 [shown for informational purposes only]	RTECS^®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 94(8),41,1979
RTECS^®- FAO Nutrition Meetings Report Series 1967 [shown for informational purposes only]	RTECS^®- FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. 44A,1,1967
RTECS^®- Food and Chemical Toxicology 1987 [shown for informational purposes only]	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 25,505,1987
RTECS^®- Food and Chemical Toxicology 1993 [shown for informational purposes only]	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 31,463,1993
RTECS^®- Food and Cosmetics Toxicology 1979 [shown for informational purposes only]	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 17,259,1979
RTECS^®- Food and Cosmetics Toxicology 1980 [shown for informational purposes only]	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 18,547,1980
RTECS^®- Food and Cosmetics Toxicology 1964 [shown for informational purposes only]	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 2,327,1964
RTECS^®- Journal of Reproduction and Fertility 1979 [shown for informational purposes only]	RTECS^®- Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- 55,347,1979
RTECS^®- Journal of the Society of Cosmetic Chemists 1977 [shown for informational purposes only]	RTECS^®- Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- 28,357,1977
RTECS^®- Journal of the Society of Cosmetic Chemists 1977 [shown for informational purposes only]	RTECS^®- Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 28,357,1977
RTECS^®- Toxicology 2005 [shown for informational purposes only]	RTECS^®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 206,285,2005
RTECS^®- Toxicology 1995 [shown for informational purposes only]	RTECS^®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 96,105,1995
RTECS^®- Urological Research 1992 [shown for informational purposes only]	RTECS^®- Urological Research. (Springer Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1973- 20,139,1992