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CINOXATE

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Cancer

Concern Reference
One or more in vitro tests on mammalian cells show positive mutation resultsShimoi K, Nakamura Y, Noro T, Tomita I, Sasaki YF, Imanishi H, Matsumoto K, Shirasu Y

Organ system toxicity (non-reproductive)

Concern Reference
Limited evidence of skin toxicity

Data gaps

Concern Reference
7 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Data Sources

Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Shimoi K, Nakamura Y, Noro T, Tomita I, Sasaki YF, Imanishi H, Matsumoto K, Shirasu Y. Enhancing effects of cinoxate and methyl sinapate on the frequencies of sister-chromatid exchanges and chromosome aberrations in cultured mammalian cells. Mutat Res. 1989 Jun;212(2):213-21.
{Odio, 1993}

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer