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CHLOROXYLENOL


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
 
Use restrictions
 
 
Other HIGH concerns: Irritation (skin, eyes, or lungs), Occupational hazards, Persistence and bioaccumulation; Other MODERATE concerns: Organ system toxicity (non-reproductive); Other LOW concerns: Data gaps, Ecotoxicology

Function(s): Cosmetic Biocide; Deodorant Agent; Preservative; ANTIMICROBIAL

Synoym(s): 4-CHLORO-3,5-DIMETHYL- PHENOL; 4-CHLORO-3,5-DIMETHYLPHENOL; 4-CHLORO-3,5-XYLENOL; CHLORODIMETHYL- PHENOL; CHLORODIMETHYLHYDROXYBENZENE; P-CHLORO-M-XYLENOL; PCMX; PHENOL, CHLORODIMETHYL-; XYLENOL, ARCHLORO; 2-CHLORO-5-HYDROXY-1,3-DIMETHYLBENZENE; 2-CHLORO-5-HYDROXY-M-XYLENE

Allergies/immunotoxicity

Concern Reference
Limited evidence of immune system toxicity or allergies (only for products for use on skin)European Union - Classification & Labelling
Limited evidence of immune system toxicity or allergiesA Relational Database of Hazardous Chemicals and Occupational Diseases

Persistence and bioaccumulation

Concern Reference
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Occupational hazards

Concern Reference
Allowed workplace exposures restricted to low dosesEuropean Union - Classification & Labelling

Irritation (skin, eyes, or lungs)

Concern Reference
Classified as irritantEuropean Union - Classification & Labelling
Human irritant - strong evidence (only for products for use around the eyes, on the skin, or may be aerosolized (airborne))Cosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

Concern Reference
Classified as toxic or harmful (only for products for use around the mouth; products for use on the lips)European Union - Classification & Labelling
Limited evidence of sense organ toxicityA Relational Database of Hazardous Chemicals and Occupational Diseases
One or more animal studies show effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Categorized List of Inert Pesticide Ingredients
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
191 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Data Sources

A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996.
A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, Nordic Council of Ministers (Nordic Allergy Project). Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
Emerging PBTs from peer-reviewed literature
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer