CHLORHEXIDINE DIGLUCONATE

Score	Data: Good
CAS	18472-51-0
anti-aging (22 products)
around-eye cream (12 products)
facial moisturizer/ treatment (10 products)
moisturizer (9 products)
lubricant/ spermicide (5 products)
Show all 64 products that contain CHLORHEXIDINE DIGLUCONATE.
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CHLORHEXIDINE DIGLUCONATE

image source: PubChem

Health concerns of ingredient
About the ratings
Cancer	no information
Developmental & reproductive toxicity	no information
Allergies & immunotoxicity
Use restrictions
Contamination concerns: none
Other MODERATE concerns: Irritation (skin, eyes, or lungs)

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Cosmetic Biocide; Oral Care Agent; Preservative; ANTIMICROBIAL

About CHLORHEXIDINE DIGLUCONATE: Chlorhexidine Digluconate is a salt of Chlorhexidine (q.v.) and gluconic acid.

Synonym(s): N,N'-BIS (4-CHLOROPHENYL) -3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, COMPD. WITH; D-GLUCONIC ACID; CHLORHEXIDINE BIGLUCONATE; CHLORHEXIDINE GLUCONATE; CHLORHEXIDINE GLUCONATE SOLUTION; D-GLUCONIC ACID, COMPD. WITH; N,N'-BIS (4- CHLOROPHENYL) -3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE; 1,1'-HEXAMETHYLENE BIS (5- (P-CHLOROPHENYL) BIGUANIDE) DIGLUCONATE; COMPD. WITH N,N'-BIS (4-CHLOROPHENYL) -3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE; COMPD. WITH D-GLUCONIC ACID; CHLORHEXIDINE GLUCONATE

Allergies/immunotoxicity
type of concern	product conditions	reference
Human immune and respiratory toxicant - strong evidence		Association of Occupational and Environmental Clinics
Human skin toxicant - strong evidence
Human immune system toxicant - moderate evidence		National Library of Medicine HazMap

Use restrictions
type of concern	product conditions	reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)		Japan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		Canada - Prohibited and Restricted Cosmetics Ingredients
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		Cosmetic Ingredient Review Assessments

Irritation (skin, eyes, or lungs)
type of concern	product conditions	reference
Human skin irritant - moderate evidence		National Library of Medicine HazMap

Data gaps
type of concern	product conditions	reference
1,961 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Ecotoxicology
type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be bioaccumulative

Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)
type of concern	product conditions	reference
Classified as not expected to be potentially toxic or harmful		Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	CHLORHEXIDINE DIGLUCONATE	QQQ02,QQQ36; C-
Japan's Standards for Cosmetics	CHLORHEXIDINE GLUCONATE	Japan - restricted for use in some types of cosmetics (concentration limit)
Japan's Standards for Cosmetics	CHLORHEXIDINE GLUCONATE	Japan - restricted for use in some types of cosmetics (concentration limit)
Environment Canada Domestic Substance List	D-GLUCONIC ACID, COMPD. WITH N,N''-BIS(4-CHLOROPHENYL) -3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE (2:1)	,,,,,,,,,
Association of Occupational and Environmental Clinics	CHLORHEXIDINE	• ARs
Canada - Prohibited and Restricted Cosmetics Ingredients	CHLORHEXIDINE	Restricted
Cosmetic Ingredient Review Assessments	CHLORHEXIDINE	QQQ02,QQQ36; M+
National Library of Medicine HazMap	CHLORHEXIDINE	AS: Yes;DE: Contact Dermatitis, Photoallergic;
Japan's Standards for Cosmetics	CHLORHEXIDINE	Japan - restricted for use in some types of cosmetics (concentration limit)
Japan's Standards for Cosmetics	CHLORHEXIDINE	Japan - restricted for use in some types of cosmetics (concentration limit)
Japan's Standards for Cosmetics	CHLORHEXIDINE	Japan - restricted for use in some types of cosmetics (concentration limit)

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study	appears on list as	classification(s)
RTECS^®- Drugs in Japan (Ethical Drugs) 1982	CHLORHEXIDINE DIGLUCONATE	• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS^®- Eisei Kagaku 1986	CHLORHEXIDINE DIGLUCONATE	• mutagenic - Positive mutation assay: DNA repair (Bacillus subtilis )
RTECS^®- Eisei Kagaku 1986	CHLORHEXIDINE DIGLUCONATE	• mutagenic - Positive mutation assay: DNA repair (Bacillus subtilis )
RTECS^®- Toksikologicheskii Vestnik 2001	CHLORHEXIDINE DIGLUCONATE	• brain, nervous system, or behavioral effect - Excitement (mouse LD50) • respiratory - Respiratory depression (mouse LD50) • brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (mouse LD50)

references
government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Japan's Standards for Cosmetics	Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
Environment Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
Association of Occupational and Environmental Clinics	AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
Canada - Prohibited and Restricted Cosmetics Ingredients	Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
National Library of Medicine HazMap	NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
RTECS^®- Drugs in Japan (Ethical Drugs) 1982 [shown for informational purposes only]	RTECS^®- Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) 6,255,1982
RTECS^®- Eisei Kagaku 1986 [shown for informational purposes only]	RTECS^®- Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953- 32,171,1986
RTECS^®- Eisei Kagaku 1986 [shown for informational purposes only]	RTECS^®- Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 32,171,1986
RTECS^®- Toksikologicheskii Vestnik 2001 [shown for informational purposes only]	RTECS^®- Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown (2),36,2001