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LILIAL
Score
Data: Limited
CAS80-54-6
hair color and bleaching (198 products)
conditioner (106 products)
fragrance for women (97 products)
moisturizer (87 products)
shampoo (85 products)
Show all 962 products that contain LILIAL.
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LILIAL


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicityyes
Use restrictionsyes
Contamination concerns: none
Other MODERATE concerns: Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
Other LOW concerns: Endocrine disruption, Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Fragrance Ingredient; MASKING

About LILIAL: Lilial (butylphenyl methylpropanal) is a synthetic scent ingredient; associated with allergies and contact dermatitis.

Synonym(s): BUTYLPHENYL METHYLPROPIONAL, BUTYPHENYL METHYLPROPIONAL; LILYAL; PROTECTOL PP

Allergies/immunotoxicity

type of concern product conditions reference
Possible human immune system toxicant    EU Banned and Restricted Fragrances

Use restrictions

type of concern product conditions reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)   International Fragrance Association Codes & Standards

Persistence and bioaccumulation

type of concern product conditions reference
Persistent or bioaccumulative and moderate to high toxicity concern in humans    Environment Canada Domestic Substance List
show more

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as medium human health priority    Environment Canada Domestic Substance List
show more

Endocrine disruption

type of concern product conditions reference
Associated with endocrine disruption    Charles AK, Darbre PD, 2009

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
28 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
Environment Canada Domestic Substance ListBENZENEPROPANAL, 4-(1,1-DIMETHYLETHYL)-_-METHYL-,,Moderate-Health Priority,Y-Persistent,,,,,,
EU Banned and Restricted FragrancesLILIALFragrance chemical, which is less frequently reported and thus less documented as a consumer allergen.
IFRA Fragrance Ingredient ListP-T-BUTYL-ALPHA-METHYLHYDROCINNAMIC ALDEHYDEreported as used in fragrance compounds in 2008
International Fragrance Association Codes & Standards#27 P-TERT BUTYL-ALPHA-METHYLHYDROCINNAMIC ALDEHYDE (BMHCA)Restricted
International Fragrance Association Codes & StandardsP-TERT-BUTYL-ALPHA-METHYLHYDROCINNAMIC ALDEHYDE (BMHCA)Restricted
International Fragrance Association Codes & StandardsP-TERT-BUTYL-ALPHA-METHYLHYDROCINNAMIC ALDEHYDE (BMHCA)Restricted
International Fragrance Association Codes & StandardsP-TERT-BUTYL-ALPHA-METHYLHYDROCINNAMIC ALDEHYDE (BMHCA) 37THRestricted
Charles AK, Darbre PD, 2009BUTYLPHENYLMETHYLPROPIONALButylphenylmethylpropional (Lilial) demonstrated estrogenic activity by increasing the proliferation of breast cancer cells in vitro.

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Contact Dermatitis 2001LILIAL• skin - Cutaneous sensitization (experimental) (mouse TDLo)
RTECS®- Food and Cosmetics Toxicology 1978LILIAL• skin - Primary skin irritant (rabbit )
RTECS®- National Technical Information Service LILIAL• reproductive - Testes, epididymis, sperm duct (rat TDLo)
RTECS®- National Technical Information Service 5449LILIAL• respiratory - Dyspnea (mouse LD50)
• brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (mouse LD50)
RTECS®- National Technical Information Service 2958LILIAL• reproductive - Musculoskeletal system (rabbit TDLo)

references
government/industry list/academic study reference
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU Banned and Restricted FragrancesSCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
International Fragrance Association Codes & StandardsIFRA (International Fragrance Association). 2006. Codes and Standards.
Open scientific literatureCharles AK, Darbre PD. 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5): 422-34.
RTECS®- Contact Dermatitis 2001 [shown for informational purposes only]RTECS®- Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- 45,89,2001
RTECS®- Food and Cosmetics Toxicology 1978 [shown for informational purposes only]RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 16,659,1978
RTECS®- National Technical Information Service [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0524035-3
RTECS®- National Technical Information Service 5449 [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0535449
RTECS®- National Technical Information Service 2958 [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0572958

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