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BUTYLENE GLYCOL
Score
Data: Limited
CAS107-88-0
facial moisturizer/ treatment (442 products)
anti-aging (406 products)
facial cleanser (218 products)
foundation (208 products)
sunscreen: makeup (184 products)
Show all 2,596 products that contain BUTYLENE GLYCOL.
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BUTYLENE GLYCOL


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other MODERATE concerns: Irritation (skin, eyes, or lungs)
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Fragrance Ingredient; Skin-Conditioning Agent - Miscellaneous; Solvent; ViscosityDecreasing Agent; HUMECTANT; MASKING; SKIN CONDITIONING; VISCOSITY CONTROLLING

About BUTYLENE GLYCOL: Butylene glycol (1.3-Butanediol) is a small organic alcohol used as solvent and conditioning agent.

Synonym(s): ACEROLA EXTRACT BG-25; 1,3-BUTANEDIOL; 1,3-BUTYLENE GLYCOL; 1,3-DIHYDROXYBUTANE; DIOSCOREA COMPOSITA EXTRACT BG; 3-HYDROXY-1-BUTANOL; PHYTO COLLAGE BD-II; QUILLAJA EXTRACT BG; ROSE APPLE LEAF EXTRACT BG-30; 1,3BUTANEDIOL; BUTANE-1,3-DIOL

Irritation (skin, eyes, or lungs)

type of concern product conditions reference
Human irritant - strong evidence products for use around the eyes, on the skin, or may be aerosolized (airborne)  Cosmetic Ingredient Review Assessments

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
253 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Food Additive Status
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List
show more

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
FDA Food Additive Status1,3-BUTYLENE GLYCOL• SOLV
• REG
• GMP
• In nat & syn flavoring substances except where standards preclude use -173.220; 573.225. Used in the manufacture of sausage casings as a formulation aid and processing aid - CFR172.712.
Cosmetic Ingredient Review AssessmentsBUTYLENE GLYCOLQQQ01,QQQ11; IR, X
FDA Everything Added to Food1,3-BUTYLENE GLYCOL• ASP
Environment Canada Domestic Substance List1,3-BUTANEDIOL,,,,,,,,,
Association of Occupational and Environmental Clinics1,3-BUTYLENE GLYCOL• o
IFRA Fragrance Ingredient List1,3-BUTANEDIOLreported as used in fragrance compounds in 2008

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986BUTYLENE GLYCOL• sense organ - Primary eye irritant (rabbit )
• skin - Primary skin irritant (rabbit )
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984BUTYLENE GLYCOL• brain, nervous system, or behavioral effect - Ataxia (rat TDLo)
• broad systemic - Broad systemic toxicity (guinea pig LD50)
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994BUTYLENE GLYCOL• brain, nervous system, or behavioral effect - Abuse (mammal TDLo)
• brain, nervous system, or behavioral effect - Alteration of classical conditioning (mammal TDLo)
• endocrine system - Changes in LH (mammal TDLo)
RTECS®- American Journal of Ophthalmology 1946BUTYLENE GLYCOL• sense organ - Primary eye irritant (rabbit )
RTECS®- American Journal of Ophthalmology 1946BUTYLENE GLYCOL• sense organ - Primary eye irritant (rabbit )
RTECS®- Journal of Industrial Hygiene and Toxicology 1941BUTYLENE GLYCOL• broad systemic - Broad systemic toxicity (rat LD50)
• gastrointestinal - Other changes (guinea pig LD50)
• brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (guinea pig LD50)
RTECS®- Journal of the American College of Toxicology 1986BUTYLENE GLYCOL• reproductive - Growth statistics (rat TDLo)
RTECS®- Journal of the American Pharmaceutical Association, Scientific Edition 1956BUTYLENE GLYCOL• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Toxicology and Applied Pharmacology 1979BUTYLENE GLYCOL• broad systemic - Broad systemic toxicity (mouse LD50)

references
government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
Association of Occupational and Environmental ClinicsAOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 [shown for informational purposes only]RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,207,1986
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 [shown for informational purposes only]RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,151,1984
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 [shown for informational purposes only]RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,152,1994
RTECS®- American Journal of Ophthalmology 1946 [shown for informational purposes only]RTECS®- American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- 29,1363,1946
RTECS®- American Journal of Ophthalmology 1946 [shown for informational purposes only]RTECS®- American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 29,1363,1946
RTECS®- Journal of Industrial Hygiene and Toxicology 1941 [shown for informational purposes only]RTECS®- Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. 23,259,1941
RTECS®- Journal of the American College of Toxicology 1986 [shown for informational purposes only]RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 5(4),189,1986
RTECS®- Journal of the American Pharmaceutical Association, Scientific Edition 1956 [shown for informational purposes only]RTECS®- Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. 45,669,1956
RTECS®- Toxicology and Applied Pharmacology 1979 [shown for informational purposes only]RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 49,385,1979

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