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BUTOXYDIGLYCOL
Score
Data: Limited
CAS112-34-5
hair color and bleaching (27 products)
polish remover (6 products)
nail treatment (1 products)
Show all 33 products that contain BUTOXYDIGLYCOL.
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BUTOXYDIGLYCOL


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicityyes
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other HIGH concerns: Irritation (skin, eyes, or lungs)
Other MODERATE concerns: Organ system toxicity (non-reproductive)
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Fragrance Ingredient; Solvent; Viscosity Decreasing Agent; MASKING; VISCOSITY CONTROLLING

About BUTOXYDIGLYCOL: Butoxydiglycol is an ether alcohol.

Synonym(s): 2- (2-BUTOXYETHOXY) ETHANOL; BUTYL CARBITOL; BUTYL DIGLYCOL; BUTYL DIOXITOL; DIETHYLENE GLYCOL MONOBUTYL ETHER; ETHANOL, 2- (2-BUTOXYETHOXY) -; MONOBUTYL DIETHYLENE GLYCOL ETHER; 2- (2-BUTOXYETHOXY) - ETHANOL; ETHANOL, 2 (2BUTOXYETHOXY) ; 2- (2-BUTOXYETHOXY) ETHANOL; BUCB

Developmental/reproductive toxicity

type of concern product conditions reference
Limited evidence of reproductive toxicity products that may be aerosolized (airborne)  National Library of Medicine HazMap

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as expected to be toxic or harmful    Environment Canada Domestic Substance List
show more

Irritation (skin, eyes, or lungs)

type of concern product conditions reference
Classified as irritant    European Union - Classification & Labelling

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
34 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Neurotoxicity

type of concern product conditions reference
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study products that may be aerosolized (airborne)  National Library of Medicine HazMap

Cancer

type of concern product conditions reference
Not likely to be carcinogenic in humans    EPA Water Disinfection By-Products Carcinogenicity

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
European Union - Classification & Labelling2-(2-BUTOXYETHOXY)ETHANOLXi; R36
EPA Water Disinfection By-Products Carcinogenicity2-(2-BUTOXYETHOXY)-ETHANOLLow
Environment Canada Domestic Substance ListETHANOL, 2-(2-BUTOXYETHOXY)-Y-Categorization,Y-Human health,Moderate-Health Priority,,,,,,,
IFRA Fragrance Ingredient ListDIETHYLENE GLYCOL MONOBUTYL ETHERreported as used in fragrance compounds in 2008
National Library of Medicine HazMapDIETHYLENE GLYCOL MONOBUTYL ETHERAN: Anemia, Aplastic;RT: Yes;HE: Hepatotoxin, Secondary;NE: Yes;NT: CNS Solvent Syndrome;FL: 2: high ambient temperature required;MA: 100 mg/m3;
EPA Categorized List of Inert Pesticide IngredientsDIETHYLENE GLYCOL MONOBUTYL ETHERList 2 Inert

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- "Patty's Industrial Hygiene and Toxicology," 3rd rev 1982BUTOXYDIGLYCOL• broad systemic - Broad systemic toxicity (rabbit LD50)
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986BUTOXYDIGLYCOL• sense organ - Primary eye irritant (rabbit )
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984BUTOXYDIGLYCOL• respiratory - Dyspnea (guinea pig LD50)
• liver - Other changes (guinea pig LD50)
• brain, nervous system, or behavioral effect - Tetany (guinea pig LD50)
RTECS®- American Journal of Ophthalmology 1946BUTOXYDIGLYCOL• sense organ - Primary eye irritant (rabbit )
RTECS®- American Journal of Ophthalmology 1946BUTOXYDIGLYCOL• sense organ - Primary eye irritant (rabbit )
RTECS®- Dow Chemical Company Reports BUTOXYDIGLYCOL• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology 1947BUTOXYDIGLYCOL• blood - Changes in spleen (mouse LD50)
• kidney or renal system - Changes in tubules (including acute renal failure, acute tubular (mouse LD50)
• respiratory - Other changes (mouse LD50)
RTECS®- Gigiena i Sanitariya 1981BUTOXYDIGLYCOL• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Journal of Industrial Hygiene and Toxicology 1941BUTOXYDIGLYCOL• brain, nervous system, or behavioral effect - General anesthetic (guinea pig LD50)
• gastrointestinal - Other changes (guinea pig LD50)
RTECS®- Journal of the American College of Toxicology 1993BUTOXYDIGLYCOL• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- National Technical Information Service 0960BUTOXYDIGLYCOL• metabolic - Weight loss or decreased weight gain (rat TDLo)
• brain, nervous system, or behavioral effect - Food intake (animal) (rat TDLo)
• blood - Pigmented or nucleated red blood cells (rat TDLo)
RTECS®- Toxicologist 1986BUTOXYDIGLYCOL• metabolic - Weight loss or decreased weight gain (rat TDLo)

references
government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
EPA Water Disinfection By-Products CarcinogenicityEPA (U.S. Environmental Protection Agency). 2006. EPA Water Disinfection By-Products with Carcinogenicity Estimates. Last updated: 10 April 2006.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
EPA Categorized List of Inert Pesticide IngredientsEPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
RTECS®- "Patty's Industrial Hygiene and Toxicology," 3rd rev 1982 [shown for informational purposes only]RTECS®- "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. 2C,3964,1982
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 [shown for informational purposes only]RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,635,1986
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 [shown for informational purposes only]RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,174,1984
RTECS®- American Journal of Ophthalmology 1946 [shown for informational purposes only]RTECS®- American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- 29,1363,1946
RTECS®- American Journal of Ophthalmology 1946 [shown for informational purposes only]RTECS®- American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 29,1363,1946
RTECS®- Dow Chemical Company Reports [shown for informational purposes only]RTECS®- Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640) MSD-41
RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology 1947 [shown for informational purposes only]RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. 6,342,1947
RTECS®- Gigiena i Sanitariya 1981 [shown for informational purposes only]RTECS®- Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- 46(2),14,1981
RTECS®- Journal of Industrial Hygiene and Toxicology 1941 [shown for informational purposes only]RTECS®- Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. 23,259,1941
RTECS®- Journal of the American College of Toxicology 1993 [shown for informational purposes only]RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 12,139,1993
RTECS®- National Technical Information Service 0960 [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0570960
RTECS®- Toxicologist 1986 [shown for informational purposes only]RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 6,164,1986

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