Health Concerns of the Ingredient:
Overall Hazard
Developmental &
reproductive toxicity
Allergies & immunotoxicity
Possible impurity in: see all ingredients | products
Synoym(s): STRYCHNIDIN10ONE, 2,3DIMETHOXY; (-) -BRUCINE; 10,11-DIMETHYSTRYCHNINE; 2,3-DIMETHOXY-STRYCHNINE; 2,3-DIMETHOXYSTRYCHNIDIN-10-ONE; BRUCINA (ITALIAN) ; BRUCINE ALKALOID; DIMETHOXY STRYCHNINE; RCRA WASTE NUMBER P018; STRYCHNINE, 2,3-DIMETHOXY-
Use restrictions
| Concern |
Reference |
|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
Occupational hazards
| Concern |
Reference |
|---|
| Allowed workplace exposures restricted to very low doses | European Union - Classification & Labelling |
Organ system toxicity (non-reproductive)
| Concern |
Reference |
|---|
| Classified as very toxic or harmful (only for products for use around the mouth; products for use on the lips; products that may be aerosolized (airborne)) | European Union - Classification & Labelling |
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List |
| One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) | EPA Toxic Release Inventory PBTs |
Ecotoxicology
| Concern |
Reference |
|---|
| Wildlife and environmental toxicity | European Union - Classification & Labelling |
| Suspected to be an environmental toxin and be persistent or bioaccumulative | Environment Canada Domestic Substance List |
| Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern |
Reference |
|---|
| Insufficient data to determine safety | Cosmetic Ingredient Review Assessments |
| 283 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | NLM PubMed |
Persistence and bioaccumulation
| Concern |
Reference |
|---|
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
| CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. |
| EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule. |
| European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ . |
| Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007. |
| NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov. |
Products Containing the Ingredient
About the ratings
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.
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