BISABOLOL || Skin Deep® Cosmetics Database | Environmental Working Group

BISABOLOL

Score	Data: Limited
CAS	515-69-5
facial moisturizer/ treatment (161 products)
anti-aging (105 products)
moisturizer (76 products)
facial cleanser (51 products)
around-eye cream (44 products)
Show all 789 products that contain BISABOLOL.
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BISABOLOL

image source: PubChem

Health concerns of ingredient
About the ratings
Cancer	no information
Developmental & reproductive toxicity	no information
Allergies & immunotoxicity	no information
Use restrictions	no information
Contamination concerns: none
Other HIGH concerns: Enhanced skin absorption
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Fragrance Ingredient; Skin-Conditioning Agent - Miscellaneous; MASKING; SKIN CONDITIONING; SOOTHING

About BISABOLOL: Bisabolol is a scent ingredient naturally occurring in camomile.

Synonym(s): .ALPHA.-BISABOLOL; ALPHA BISABOLOL; (+-) -ALPHA-BISABOLOL; (-) -ALPHA-BISABOLOL; ALPHA-BISABOLOL; DL-ALPHA-BISABOLOL; DRAGOSANTOL

Enhanced skin absorption
type of concern	product conditions	reference
Penetration enhancer		Cosmetic Ingredient Review Assessments

Data gaps
type of concern	product conditions	reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		Cosmetic Ingredient Review Assessments
137 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Ecotoxicology
type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)
type of concern	product conditions	reference
Classified as not expected to be potentially toxic or harmful		Environment Canada Domestic Substance List

Persistence and bioaccumulation
type of concern	product conditions	reference
Not suspected to be persistent		Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	BISABOLOL	QQQ01,QQQ11; PE
Environment Canada Domestic Substance List	3-CYCLOHEXENE-1-METHANOL, _,4-DIMETHYL-_-(4-METHYL-3-PENTENYL)-, (R,R)-	,,,,Y-Bioaccumulative,,,,,
IFRA Fragrance Ingredient List	.ALPHA.-BISABOLOL	reported as used in fragrance compounds in 2008

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study	appears on list as	classification(s)
RTECS^®- International Journal of Toxicology	BISABOLOL	• metabolic - Weight loss or decreased weight gain (rat TDLo) • liver - Changes in liver weight (rat TDLo) • endocrine system - Changes in testicular weight (rat TDLo) • respiratory - Dyspnea (mouse LD50) • skin - Hair (mouse LD50) • brain, nervous system, or behavioral effect - Tremor (mouse LD50)

references
government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environment Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS^®- International Journal of Toxicology [shown for informational purposes only]	RTECS^®- International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997- 18(Suppl