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BENZOPHENONE-1


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
 
Use restrictions
 
 
Other HIGH concerns: Endocrine disruption; Other LOW concerns: Data gaps

About BENZOPHENONE-1: Benzophenone-1 is a benzene-based UV absorber.

Function(s): Ultraviolet Light Absorber; UV ABSORBER

Synoym(s): (2,4-DIHYDROXYPHENYL) PHENYL- METHANONE; (2,4-DIHYDROXYPHENYL) PHENYLMETHANONE; 2,4-DIHYDROXYBENZOPHENONE; 4-BENZOYL RESORCINOL; BENZORESORCINOL; METHANONE, (2,4-DIHYDROXYPHENYL) PHENYL-; METHANONE, (2,4DIHYDROXYPHENYL) PHENYL; 2,4-DIHYDROXYBENZOFENON (CZECH) ; 2,4-DIHYDROXYBENZOPHENONE; EASTMAN INHIBITOR DHPB; QUINSORB 010

Allergies/immunotoxicity

Concern Reference
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Human skin toxicant or allergen - strong evidence

Endocrine disruption

Concern Reference
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
One or more studies show significant wildlife and the environment disruptionEuropean Commission on Endocrine Disruption
One or more animal studies show disruption at high dosesSchlumpf M, Schmid P, Durrer S, Conscience M, Maerkel K, Henseler M, et al
Associated with endocrine disruptionKunz PY, Fent K

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
122 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Kunz PY, Fent K. 2006. Estrogenic activity of UV filter mixtures. Toxicol Appl Pharmacol 217(1): 86-99.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Schlumpf M, Schmid P, Durrer S, Conscience M, Maerkel K, Henseler M, et al. 2004. Endocrine activity and developmental toxicity of cosmetic UV filters--an update. Toxicology 205(1-2): 113-122.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer