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BENZETHONIUM CHLORIDE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
Allergies & immunotoxicity
 
 
Other LOW concerns: Data gaps

About BENZETHONIUM CHLORIDE: Benzethonium Chloride is a quaternary ammonium salt. In the United States, Benzethonium Chloride may be used as an active ingredient in OTC drug products. When used as an active drug ingredient, the e ... read more

Possible impurity in: CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT (1,011 products), CITRUS PARADISI (GRAPEFRUIT) SEED EXTRACT (54 products), see all ingredients | products

Function(s): Antimicrobial Agent; Cosmetic Biocide; Deodorant Agent; Surfactant - Suspending Agent; PRESERVATIVE

Synoym(s): BENZENEMETHANAMINIUM, N,NDIMETHYLN [2 [2 [4 (1,1,3,3TETRAMETHYLBUTYL) PHENOXY] ETHOXY] ETHYL] , CHLORIDE; BENZETHONIUM CHLORIDE SOLUTION; BENZYL (DIMETHYL) (2-{2- [4- (1,1,3,3-TETRAMETHYLBUTYL) PHENOXY] ETHOXY) -ETHYL) AMMONIUM CHLORIDE; DIIS OBUTYL PHENOXY ETHOXY ETHYL DIMETHYL BENZYL AMMONIUM CHLORIDE; N,N-DIMETHYL-N- [2- [2- [4- (1,1,3,3-TETRAMETHYLBUTYL) PHENOXY] ETHOXY] ETHYL] -, BENZENEMETHANAMINIUM; N,N-DIMETHYL-N- [2- [2- [4- (1,1,3,3-TETRAMETHYLBUTYL) PHENOXY] ETHOXY] ETHYL] BENZENEMETHANAMINIUM; ANTI-GERM 77; ANTISEPTOL; ANTISEPTOL (QUARTERNARY COMPOUND) ; BENZETHONIUM CHLORIDE 1622; BENZYLDIMETHYL (2- (2- (P- (1,1,3,3-TETRAMETHYLBUTYL) PHENOXY) ETHOXY) ETHYL) AMMONIUM CHLORIDE

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmeticsJapan's Standards for Cosmetics
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
400 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer