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AVOBENZONE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
 

About AVOBENZONE: This common sunscreen ingredient offers protection from UVA rays. Sunlight can cause this ingredient to break down and lose its effectiveness for skin protection. Photodegredation is delayed by mixing ... read more

Function(s): Sunscreen Agent; Ultraviolet Light Absorber; UV ABSORBER; UV FILTER

Synonym(s): BUTYL METHOXYDIBENZOYLMETHANE, 1,3-PROPANEDIONE, 2-BUTYL-2-METHOXY-1,3-DIPHENYL-; 2-BUTYL-2-METHOXY-1,3-DIPHENYL- 1,3-PROPANEDIONE; 4-TERT-BUTYL-4'-METHOXYDIBENZOYLMETHANE; AVO; AVOBENZONA; AVOBENZONUM; BMDBM; EINECS 274-581-6; METHOXYDIBENZOYLMETHANE; PARSOL 1789

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)Japan's Standards for Cosmetics

Cancer

Concern Reference
One or more in vitro tests on mammalian cells show positive mutation resultsDamiani, E

Allergies/immunotoxicity

Concern Reference
Associated with immunotoxicity or allergiesStitt WZD, Scott GA, Martin RE, Gaspari AA

Data gaps

Concern Reference
253 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Decreased skin absorption

Concern Reference
Limited potential to absorb into the skin.Hayden CGJ, Cross SE, Anderson C, Saunders NA, Roberts MS

Enhanced skin absorption

Concern Reference
Absorbs into the skinKlinubol P, Asawanonda P, Wanichwecharungruang SP

Persistence and bioaccumulation

Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Contamination concerns

Impurity Score
BENZOIC ACID
Data: Fair
4-T-BUTYLBENZOIC ACID
Data: Limited
BENZALDEHYDE
Data: Fair
P-ANISIC ACID
Data: Limited
ACETOPHENONE
Data: Fair
DIBENZOYLMETHANE
Data: Limited

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data Sources

Damiani, E., L. Greci, et al. (1999). "Nitroxide radicals protect dna from damage when illuminated in vitro in the presence of dibenzoylmethane and a common sunscreen ingredient." Free Radical Biology and Medicine 26: 809-816.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Hayden CGJ, Cross SE, Anderson C, Saunders NA, Roberts MS. 2005. Sunscreen penetration of human skin and related keratinocyte toxicity after topical application. Skin Pharmacology and Physiology 18(4): 170-174.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
Klinubol P, Asawanonda P, Wanichwecharungruang SP. Transdermal penetration of UV filters. Skin Pharmacol Physiol 2008; 21 (1):23-9.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Roscher N, Lindemann M, Kong S, Cho C, Jiang P. 1994. Photodecomposition of several compounds commonly used as sunscreen agents. J Photochem Photobiol A 80: 417-421; Dondi D, Albini A, Serpone N. 2006. Interactions between different solar UVB/UVA filters contained in commercial suncreams and consequent loss of UV protection. Photochem Photobiol Sci 5(9): 835-843; Schwack W, Rudolph T. 1995. Photochemistry of dibenzoyl methane UVA filters part I. J Photochem Photobiol B Biol 28: 229-234.
Stitt WZD, Scott GA, Martin RE, Gaspari AA. 1996. Multiple chemical sensitivities, including inatrogenic allergic contact dermatitis, in a patient with chronic actinic dermatitis: implication for management. American Journal of Contact Dermatitis 7(3): 166-170.; Buckley D, Wayte J, O

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer